Effects of desipramine and maprotiline on the coeruleus-cortical noradrenergic system in anaesthetized rats

European Journal of Pharmacology

Volumn 312, Issue 2, 1996, Pages 189-193

  Ceci, Angelo ^a   Borsini, Franco ^a  

^a Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

Anesthetized rat; Desipramine; Extracellular recording; Locus ceruleus; Maprotiline; Prefrontal cortex

Indexed keywords

DESIPRAMINE; MAPROTILINE; OXIDOPAMINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; INTRAVENOUS DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL;

EID: 0030603244     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00600-0     Document Type: Article

References (16)

1. Andersen, P.H., 1989, The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action, Eur. J. Pharmacol. 166, 493.
2. Bel, N. and F. Artigas, 1992, Fluovoxamine preferentially increases extracellular 5-hydroxytryptamine in raphe nuclei: in vivo microdialysis study, Eur. J. Pharmacol. 229, 101.
3. Bunney, B.S. and G.K. Aghajanian, 1976, Dopamine and norepinephrine innervated cells in rat prefrontal cortex: pharmacological differentiation using microiontophoretic techniques, Life Sci. 19, 1783.
4. Ceci, A., A. Baschirotto and F. Borsini, 1993, Effect of fluoxetine on the spontaneous electrical activity of fronto-cortical neurons, Eur. J. Pharmacol. 250, 461.
5. Cedarbaun, J.M. and G.K. Aghajanian, 1976, Noradrenergic neurons of the locus coeruleus: Inhibition by epinephrine and activation by the alpha antagonist piperoxan, Brain Res. 112, 413.
6. Curtis, A.L., E. Conti and R.J. Valentino, 1993, Cocaine effects on brain noradrenergic neurons of anaesthetized and unanaesthetized rats, Neuropharmacology 32, 419.
7. Dennis, T., R. L'Heureux, C. Carter and B, Scatton, 1987, Presynaptic alpha-2 adrenoreceptors play a mayor role in the effect of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat, J. Pharmacol. Exp. Ther. 241, 642.
8. Invernizzi, R., S. Belli and R. Samanin, 1992, Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex, Brain Res. 584, 322.
9. Lacroix, D. and A. Ferron, 1988, Electrophysiological effects of methylphenidate on the coeruleus-cortical noradrenergic system in the rat, Eur. J. Pharmacol. 149, 277.
10. L'Heureux, R., T. Dennis, O. Curet and B. Scatton, 1986, Measurement of endogenous noradrenaline release in the rat cerebral cortex in vivo by transcortical dialysis. Effect of drugs affecting noradreneregic transmission, J. Neurochem. 46, 1794.
11. Maitre, L., M. Staehlin and H.J. Bein, 1971, Blockade of noradrenaline uptake by 34276-Ba, a new antidepressant drug, Biochem. Pharmacol. 20, 2169.
12. Mantz, J., C. Milla, J. Glowinski and A.M. Thierry, 1988, Differential effects of ascending neurons containing dopamine and noradrenaline in the control of spontaneous activity and of evoked responses in the rat prefrontal cortex, Neuroscience 27, 517.
13. Paxinos, G. and C. Watson, 1986, The Rat Brain in Stereotaxic Coordinates, Academic Press, New York.
14. 14C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain, Acta Scand. Pharmacol. Toxicol. 36, 395.
15. Scuvée-Moreau, J.J. and A.E. Dresse, 1979, Effect of various antidepressant drugs on the spontaneous firing rate of locus coeruleus and dorsal raphe neurons of the rat, Eur. J. Pharmacol. 57, 219.
16. Sharma, J.N., 1976, Microiontophoretic application of some monoamines and their antagonists to cortical neurones of the rat, Neuropharmacology 16, 83.