Palladium catalysed tandem cyclisation - Anion capture processes. Part 2. Cyclisation onto alkynes or allenes with hydride capture

Tetrahedron

Volumn 52, Issue 35, 1996, Pages 11479-11502

  Grigg, Ronald ^a   Loganathan, Vani ^a   Sridharan, Visuvanathar ^a   Stevenson, Paul ^b   Sukirthalingam, Sukanthini ^a   Worakun, Tanachat ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; SPIRO COMPOUND;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030603132     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4020(96)00638-2     Document Type: Article

References (56)

1. 1. Part 1. Burns, B.; Grigg, R.; Santhakumar, V.; Sridharan, V.; Stevenson, P.; Worakun, T.; Tetrahedron, 1992, 48, 7297-7320.
2. 2. For recent reviews see: Grigg, R.; J. Heterocycl. Chem., 1994, 631-639; Grigg, R.; Sridharan, V.; Comprehensive Organometallic Chem., Pergamon Press, edit. Abel, E.; Wilkinson, G.; Stone, F.G.A., Pergamon Press, 2nd Edition 1995, vol. 12, chp. 3.6.
3. 2. For recent reviews see: Grigg, R.; J. Heterocycl. Chem., 1994, 631-639; Grigg, R.; Sridharan, V.; Comprehensive Organometallic Chem., Pergamon Press, edit. Abel, E.; Wilkinson, G.; Stone, F.G.A., Pergamon Press, 2nd Edition 1995, vol. 12, chp. 3.6.
4. 3. Cascades involving CO/MR: 3-component cascades: Grigg, R.; Redpath, J.; Sridharan, V.; Wilson, D.; Tetrahedron Lett., 1994, 35, 4429-4432. 4-component cascades: Grigg, R.; Redpath, J.; Sridharan, V.; Wilson, D.; Tetrahedron Lett., 1994, 35, 7661-7664; Grigg, R.; Putnikovic, B.; Urch, C.; ibid, 1996, 37, 695-698.
5. 3. Cascades involving CO/MR: 3-component cascades: Grigg, R.; Redpath, J.; Sridharan, V.; Wilson, D.; Tetrahedron Lett., 1994, 35, 4429-4432. 4-component cascades: Grigg, R.; Redpath, J.; Sridharan, V.; Wilson, D.; Tetrahedron Lett., 1994, 35, 7661-7664; Grigg, R.; Putnikovic, B.; Urch, C.; ibid, 1996, 37, 695-698.
6. 3. Cascades involving CO/MR: 3-component cascades: Grigg, R.; Redpath, J.; Sridharan, V.; Wilson, D.; Tetrahedron Lett., 1994, 35, 4429-4432. 4-component cascades: Grigg, R.; Redpath, J.; Sridharan, V.; Wilson, D.; Tetrahedron Lett., 1994, 35, 7661-7664; Grigg, R.; Putnikovic, B.; Urch, C.; ibid, 1996, 37, 695-698.
7. 4. Cascades involving allene/amines: Grigg, R.; Sridharan, V.; Terrier, C.; Tetrahedron Lett., 1996, 37, 4221-4224; Grigg, R.; Savic, V.; Tetrahedron Lett., 1996, 37, in press.
8. 4. Cascades involving allene/amines: Grigg, R.; Sridharan, V.; Terrier, C.; Tetrahedron Lett., 1996, 37, 4221-4224; Grigg, R.; Savic, V.; Tetrahedron Lett., 1996, 37, in press.
9. 5. Grigg, R.; Wilson, D.; Sridharan, V.; unpublished observations; see also Science, 1994, 266, 32-34.
10. 6. Grigg, R.; Rasul, R.; Redpath, J.; Wilson, D.; Tetrahedron Lett., 1996, 37, 4609-4612.
11. 7. Tsuji, J., Mandai, J., Angew. Chem. Int. Ed. Engl., 1995, 34, 2589-2612.
12. 8. For examples of bis-cyclisation-anion capture see refs. 1 and 2.
13. 9. Preliminary communication: Burns, B.; Grigg, R.; Sridharan, V.; Worakun, T.; Tetrahedron Lett., 1988, 29, 4325-4328.
14. 10. Grigg, R.; Loganathan, V.; Sukirthalingam, S.; Sridharan, V.; Tetrahedron Lett., 1990, 31, 6573-6576.
15. 11. Grigg, R.; Loganathan, V.; Santhakumar, V.; Sridharan, V.; Teasdale, A.; Tetrahedron Lett., 1991, 32, 687-690; Grigg, R.; Kennewell, P.; Teasdale, A.; ibid, 1992, 33, 7789-7792; Grigg, R.; Santhakumar, V.; Sridharan, V.; Stevenson, P.; Teasdale, A.; Thornton-Pett M.; Worakun, T.; Tetrahedron, 1991, 47, 9703-9720.
16. 11. Grigg, R.; Loganathan, V.; Santhakumar, V.; Sridharan, V.; Teasdale, A.; Tetrahedron Lett., 1991, 32, 687-690; Grigg, R.; Kennewell, P.; Teasdale, A.; ibid, 1992, 33, 7789-7792; Grigg, R.; Santhakumar, V.; Sridharan, V.; Stevenson, P.; Teasdale, A.; Thornton-Pett M.; Worakun, T.; Tetrahedron, 1991, 47, 9703-9720.
17. 11. Grigg, R.; Loganathan, V.; Santhakumar, V.; Sridharan, V.; Teasdale, A.; Tetrahedron Lett., 1991, 32, 687-690; Grigg, R.; Kennewell, P.; Teasdale, A.; ibid, 1992, 33, 7789-7792; Grigg, R.; Santhakumar, V.; Sridharan, V.; Stevenson, P.; Teasdale, A.; Thornton-Pett M.; Worakun, T.; Tetrahedron, 1991, 47, 9703-9720.
18. 12. Jeffrey, T.; Tetrahedron Lett., 1991, 32, 2121-2124 and earlier papers; Grigg, R.; Sridharan, V.; Stevenson, P.; Sukirthalingam, S.; Worakun, T.; Tetrahedron, 1990, 46, 4003-4018 and earlier papers;
19. 12. Jeffrey, T.; Tetrahedron Lett., 1991, 32, 2121-2124 and earlier papers; Grigg, R.; Sridharan, V.; Stevenson, P.; Sukirthalingam, S.; Worakun, T.; Tetrahedron, 1990, 46, 4003-4018 and earlier papers;
20. 13. Salvador, R.L.; Simon, D.; Can. J. Chem., 1966, 44, 2570-2575.
21. 14. Karabelas, K.; Westerlund, C.; Hallberg, A.; J. Org. Chem., 1985, 50, 3896-3900; Nilsson, K.; Hallberg, A.; ibid, 1990, 55, 2464-2470; Larock, R.C.; Gong, W.H.; ibid, 1989, 54, 2047-2050; Abelman, M.M.; Overman, L.E.; J. Am. Chem. Soc., 1988, 110, 2328-2329; Jeffrey, T.; Tetrahedron Lett., 1992, 33, 1989-1992.
22. 14. Karabelas, K.; Westerlund, C.; Hallberg, A.; J. Org. Chem., 1985, 50, 3896-3900; Nilsson, K.; Hallberg, A.; ibid, 1990, 55, 2464-2470; Larock, R.C.; Gong, W.H.; ibid, 1989, 54, 2047-2050; Abelman, M.M.; Overman, L.E.; J. Am. Chem. Soc., 1988, 110, 2328-2329; Jeffrey, T.; Tetrahedron Lett., 1992, 33, 1989-1992.
23. 14. Karabelas, K.; Westerlund, C.; Hallberg, A.; J. Org. Chem., 1985, 50, 3896-3900; Nilsson, K.; Hallberg, A.; ibid, 1990, 55, 2464-2470; Larock, R.C.; Gong, W.H.; ibid, 1989, 54, 2047-2050; Abelman, M.M.; Overman, L.E.; J. Am. Chem. Soc., 1988, 110, 2328-2329; Jeffrey, T.; Tetrahedron Lett., 1992, 33, 1989-1992.
24. 14. Karabelas, K.; Westerlund, C.; Hallberg, A.; J. Org. Chem., 1985, 50, 3896-3900; Nilsson, K.; Hallberg, A.; ibid, 1990, 55, 2464-2470; Larock, R.C.; Gong, W.H.; ibid, 1989, 54, 2047-2050; Abelman, M.M.; Overman, L.E.; J. Am. Chem. Soc., 1988, 110, 2328-2329; Jeffrey, T.; Tetrahedron Lett., 1992, 33, 1989-1992.
25. 14. Karabelas, K.; Westerlund, C.; Hallberg, A.; J. Org. Chem., 1985, 50, 3896-3900; Nilsson, K.; Hallberg, A.; ibid, 1990, 55, 2464-2470; Larock, R.C.; Gong, W.H.; ibid, 1989, 54, 2047-2050; Abelman, M.M.; Overman, L.E.; J. Am. Chem. Soc., 1988, 110, 2328-2329; Jeffrey, T.; Tetrahedron Lett., 1992, 33, 1989-1992.
26. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
27. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
28. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
29. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
30. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
31. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
32. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
33. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
34. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
35. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
36. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
37. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
38. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
39. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
40. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
41. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
42. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
43. 15. Intermolecular addition: Besson, L.; Gore, J.; Cazes, B.; Tetrahedron Lett., 1995, 36, 3853-3856 and 3857-3860; Yamamoto, Y.; Al-Masum, M.; Fujiwara, N.; Chem. Commun., 1996, 381-382; Trost, B.M.; Gerusz, V.J.; J. Am. Chem. Soc., 1995, 117, 5156-5157. Cyclisation: Larock, R.C.; Berrios-Pena, N.G.; Fried, C.A.; J. Org. Chem., 1991, 56, 2615-2617; Larock, R.C.; Zenner, J.M.; ibid, 1995, 60, 842-848; Davies, I.W.; Scopes, D.I.C.; Gallaher, T.; Synlett., 1993, 85-87; Walkup, R.D.; Guan, L.; Kim, Y.; Kim, S.W.; Tetrahedron Lett., 1995, 36, 3805-3808; Ma, S.; Negishi, E.-I., J. Am. Chem. Soc., 1995, 117, 6345-6357; Cycloaddition: O'Connor, J.M.; Stallman, B.J.; Clark, W.G.; Shu, A.Y.; Spoda, R.E.; Stevenson, T.M.; Dieck, H.A.; J. Org. Chem., 1983, 48, 807-809; An, Z.-W.; Catellani, M.; Chiusoli, G.P.; J. Organomet. Chem., 1990, 397, C31-C32; Kelinin, V.N.; Shostakovsky, M.V.; Ponomarov, A.B.; Tetrahedron Lett., 1990, 31, 4073-4076. Larock, R.C.; Zenner, J.M.; Org. Chem., 1995, 60, 482-483; Larock, R.C.; Guo, L.; Synlett., 1995, 465-466; Larock, R.C.; Yum, E.K.; Doty, M.J.; Sham, K.K.C.; J. Org. Chem., 1995, 60, 3270-3271; Chen, C.-Y.; Lieberman, D.R.; Larsen, R.D.; Reamer, R.A.; Verhoeven, T.R.; Reider, P.J.; Cottrell, I.F.; Houghton P.G.; Tetrahedron lett., 1994, 35, 6981-6984; Larock, R.C.; Doty, M.J.; Cacchi, S.; J. Org. Chem., 1993, 58, 4579-4583; Jeschke, T.; Wensbe, D.; Annaby, U.; Gronowitz, S.; Cohen, L.A.; Tetrahedron Lett., 1993, 34, 2823-2826 and 6471-6474; Grigg, R.; Xu, H.-L.; Tetrahedron Lett., 1996, 37, 4251-4254.
44. 16. For the ability of base to control the site of anion capture in π-allylpalladium(II) species generated from allenes see: Grigg, R.; Sridharan, V.; Xu, H.-L.; J. Chem. Soc., Chem. Commun., 1995, 1903-1904.
45. 17. Murahashi, S.; Hirano, T.; Yano, T.; Am. Chem. Soc., 1978, 100, 348 - ; Murahashi, S.; Watanabe, T.; ibid, 1979, 101, 7429 - ; Murahashi, S.; Yoshimura, N.; Tsumiyama, T.; Kojima, T.; ibid, 1983, 105, 5002 -5011; Grigg, R.; Heaney, F.; J. Chem. Soc., Perkin Trans 1, 1989, 198 - ; Grigg, R.; Heaney, F.; Idle, J.; Somasunderam, A.; Tetrahedron Lett., 1990, 31, 2767-2770.
46. 17. Murahashi, S.; Hirano, T.; Yano, T.; Am. Chem. Soc., 1978, 100, 348 - ; Murahashi, S.; Watanabe, T.; ibid, 1979, 101, 7429 - ; Murahashi, S.; Yoshimura, N.; Tsumiyama, T.; Kojima, T.; ibid, 1983, 105, 5002 -5011; Grigg, R.; Heaney, F.; J. Chem. Soc., Perkin Trans 1, 1989, 198 - ; Grigg, R.; Heaney, F.; Idle, J.; Somasunderam, A.; Tetrahedron Lett., 1990, 31, 2767-2770.
47. 17. Murahashi, S.; Hirano, T.; Yano, T.; Am. Chem. Soc., 1978, 100, 348 - ; Murahashi, S.; Watanabe, T.; ibid, 1979, 101, 7429 - ; Murahashi, S.; Yoshimura, N.; Tsumiyama, T.; Kojima, T.; ibid, 1983, 105, 5002 -5011; Grigg, R.; Heaney, F.; J. Chem. Soc., Perkin Trans 1, 1989, 198 - ; Grigg, R.; Heaney, F.; Idle, J.; Somasunderam, A.; Tetrahedron Lett., 1990, 31, 2767-2770.
48. 17. Murahashi, S.; Hirano, T.; Yano, T.; Am. Chem. Soc., 1978, 100, 348 - ; Murahashi, S.; Watanabe, T.; ibid, 1979, 101, 7429 - ; Murahashi, S.; Yoshimura, N.; Tsumiyama, T.; Kojima, T.; ibid, 1983, 105, 5002 -5011; Grigg, R.; Heaney, F.; J. Chem. Soc., Perkin Trans 1, 1989, 198 - ; Grigg, R.; Heaney, F.; Idle, J.; Somasunderam, A.; Tetrahedron Lett., 1990, 31, 2767-2770.
49. 17. Murahashi, S.; Hirano, T.; Yano, T.; Am. Chem. Soc., 1978, 100, 348 - ; Murahashi, S.; Watanabe, T.; ibid, 1979, 101, 7429 - ; Murahashi, S.; Yoshimura, N.; Tsumiyama, T.; Kojima, T.; ibid, 1983, 105, 5002 -5011; Grigg, R.; Heaney, F.; J. Chem. Soc., Perkin Trans 1, 1989, 198 - ; Grigg, R.; Heaney, F.; Idle, J.; Somasunderam, A.; Tetrahedron Lett., 1990, 31, 2767-2770.
50. 18. Finch, H; Pegg, N.A.; Evans, B.; Tetrahedron Lett., 1993, 34, 8353-8356.
51. 19. Catellani, M.; Chiuisoli, G.P.; Castagnoli, C.; J. Organomet Chem., 1991, 407, 30-33; Canty, A.J.; Acc. Chem. Res., 1992, 25, 83-90.
52. 19. Catellani, M.; Chiuisoli, G.P.; Castagnoli, C.; J. Organomet Chem., 1991, 407, 30-33; Canty, A.J.; Acc. Chem. Res., 1992, 25, 83-90.
53. 20. Oppolzer, W.; Keller, T.H.; Bedoya-Zuriter, M.; Stove, C.; Tetrahedron Lett., 1989, 30, 5883-5886; Oppolzer, W.; Birkinshaw, T.N.; Bernadinelli, G.; ibid, 1990, 31, 6995-6998;
54. 20. Oppolzer, W.; Keller, T.H.; Bedoya-Zuriter, M.; Stove, C.; Tetrahedron Lett., 1989, 30, 5883-5886; Oppolzer, W.; Birkinshaw, T.N.; Bernadinelli, G.; ibid, 1990, 31, 6995-6998;
55. 21. Bäckvall, J.E.; Nystrom, J.E.; Nordberg, R.E.; J. Am. Chem. Soc., 1985, 107, 3676-3686.
56. 22. Grigg, R.; Stevenson, P.; Worakun, T.; Tetrahedron, 1988, 44, 2033-2048, 2049-2054 and 4967-4972.