Reversible encapsulation of disc-shaped guests by a synthetic, self-assembled host

Science

Volumn 271, Issue 5248, 1996, Pages 487-489

  Grotzfeld, Robert M ^a   Branda, Neil ^a   Rebek Jr , Julius ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4-XYLENE; CHLOROFORM; CYCLOHEXANE DERIVATIVE; D(3D) SYMMETRICAL DIMER 5 5; D(3D) SYMMETRICAL DIMER 5-5; IMIDAZOLE DERIVATIVE; PARA XYLENE; POLYMER; XYLENE;

ARTICLE; CHEMISTRY; CONFORMATION; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

CHLOROFORM; CYCLOHEXANES; HYDROGEN BONDING; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; POLYMERS; XYLENES;

EID: 0030602345     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5248.487     Document Type: Article

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16. Because there is competition between the solute and solvent molecules for occupancy of the cavity, the encapsulation of a desired guest molecule can be encouraged by the use of a solvent that is larger than the cavity can comfortably accommodate This tactic has been developed for carcerands and other synthetic receptors [M L C. Quan and D. J. Cram, J. Am. Chem. Soc. 113, 2754 (1991); K. T Chapman and W. C. Still, ibid 111, 3075 (1989)].
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18. The energy-minimized structure was obtained with the program MacroModel 3.5X on a Silicon Graphics Personal Iris workstation.
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