An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics

FEBS Letters

Volumn 398, Issue 1, 1996, Pages 91-96

  Weiland, Sigrid ^a   Witzemann, Veit ^b   Villarroel, Alfredo ^b   Propping, Peter ^a   Steinlein, Ortrud ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Acetylcholine receptor; Complementary DNA; Electrophysiology; Ion channel; Partial epilepsy; Xenopus laevis

Indexed keywords

ACETYLCHOLINE; COMPLEMENTARY DNA; NICOTINIC RECEPTOR;

ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG SENSITIVITY; ELECTROPHYSIOLOGY; FOCAL EPILEPSY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; MOLECULAR CLONING; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ACETYLCHOLINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA, COMPLEMENTARY; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; EPILEPSIES, PARTIAL; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PHENYLALANINE; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; SERINE; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 0030602149     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01215-X     Document Type: Article

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