Selective attenuation of μ-opioid receptor-mediated effects in rat sensory neurons by intrathecal administration of antisense oligodeoxynucleotides

Neuroscience Letters

Volumn 218, Issue 1, 1996, Pages 17-20

  Khasar, Sachia G ^a   Gold, Michael S ^a   Dastmalchi, Shaharam ^a   Levine, Jon D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Analgesia; Antinociception; Antisense oligodeoxynucleotide; Intrathecal; Nociception; Pain; Sensory neuron; Opioid receptor

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ADENOSINE RECEPTOR STIMULATING AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; PROSTAGLANDIN E2;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE;

EID: 0030601879     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)13111-6     Document Type: Article

References (14)

1. [1] Aley, K.O., Green, P.G. and Levine, J.D., Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal, J. Neurosci., 15 (1995) 8031-8038.
2. [2] Gold, M.S., Dastmalchi, S. and Levine, J.D., Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat in vitro, Neuroscience, 71 (1996) 262-275.
3. [3] Hunter, J.C., Woodburn, V.L., Durieux, C., Pettersson, E.K., Poat, J.A. and Hughes, J., C-fos antisense oligodeoxynucleotide increases formalin-induced nociception and regulates preprodynorphin expression., Neuroscience, 65 (1995) 485-492.
4. [4] Khasar, S.G., Green, P.G. and Levine, J.D., Comparison of intradermal and subcutaneous hyperalgesic effects of inflammatory mediators in the rat, Neurosci. Lett., 153 (1993) 215-218.
5. [5] Khasar, S.G., Wang, J.F., Taiwo, Y.O., Heller, P.H., Green, P.G. and Levine, J.D., Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?, Neuroscience, 67 (1995) 189-195.
6. [6] Levine, J.D. and Taiwo, Y.O., Involvement of the mu-opiate receptor in peripheral analgesia, Neuroscience, 32 (1989) 571-575.
7. [7] Narita, M. and Tseng, L.F., Stimulation of spinal delta-opioid receptors in mice selectively enhances the attenuation of delta-opioid receptor-mediated antinociception by antisense oligodeoxynucleotide, Eur. J. Pharmacol., 284 (1995) 185-189.
8. [8] Pilowsky, P.M., Suzuki, S. and Minson, J.B., Antisense oligonucleotides: a new tool in neuroscience, Clin. Exp. Pharmacol. Physiol., 21 (1994) 935-944.
9. [9] Rossi, G., Pan, Y.X., Cheng, J. and Pasternak, G.W., Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor, Life Sci., 54 (1994) PL375-PL379.
10. [10] Schroeder, J.E., Fischbach, P.S., Zheng, D. and McCleskey, E.W., Activation of mu opioid receptors inhibits transient high-and low-threshold Ca2 + currents, but spares a sustained current, Neuron, 6 (1991) 13-20.
11. [11] Standifer, K.M., Chien, C.C., Wahlestedt, C., Brown, G.P. and Pasternak, G.W., Selective loss of delta opioid analgesia and binding by antisennse oligodeoxynucleotide to delta opioid receptor, Neuron, 12 (1994) 805-810.
12. [12] Taiwo, Y.O. and Levine, J.D., Direct cutaneous hyperalgesia induced by adenosine, Neuroscience, 38 (1990) 752-762.
13. [13] Taiwo, Y.O. and Levine, J.D., Kappa-and delta-opioids block sympathetically dependent hyperalgesia, J. Neurosci., 11 (1991) 571-575.
14. [14] Yaksh, T.L. and Rudy, T.A., Studies on the direct spinal action of narcotics in the production of analgesia in the rat, J. Pharmacol. Exp. Ther., 202 (1977) 411-428.