A place for statistics in the generation and analysis of genetic toxicity data: A response to 'rodent mutation assay data presentation and statistical assessment'

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 357, Issue 1-2, 1996, Pages 257-260

  Carr, Gregory J ^a   Gorelick, Nancy J ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

lacI; lacZ; Mutation; Statistics; Transgenic

Indexed keywords

GENOTOXICITY; MOUSE; MUTAGEN TESTING; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; SHORT SURVEY; STATISTICS; TRANSGENE;

RODENTIA;

EID: 0030601853     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00132-7     Document Type: Article

References (12)

1. Andrews, J.L., V.E. Walker, P.B. Upton, J.G. deBoer and N.J. Gorelick (1996) Cyclosphosphamide-induced mutations are detected at the hprt but not the lacI loci in splenic T-cells of exposed Big Blue mice, Environ. Mol. Mutagen., 27 (Suppl. 27), 4.
2. Ashby, J. (1994) Statistical versus biological significance of genetic toxicity data, Mutation Res., 308, 109-110
3. Ashby, J. (1995) Rodent mutation assay data presentation and statistical assessment, Mutation Res., 331, 233-235.
4. Ashby, J. and H. Tinwell (1995) A sequential approach to testing with the rodent bone marrow micronucleus assay: obviation of the need for statistical analyses of data, Mutation Res., 327, 49-55.
5. Carr, G.J. and N.J. Gorelick (1994) Statistical tests of significance in transgenic mutation assays: Considerations on the experimental unit, Environ. Mol. Mutagen., 24, 276-282.
6. Carr, G.J. and N.J. Gorelick (1995) Statistical design and analysis of mutation studies in transgenic mice, Environ. Mol. Mutagen., 25, 246-255.
7. Festing, M.F.W, and D.P. Lovell (1995) The need for statistical analysis of rodent micronucleus test data. Comment on the paper by Ashby and Tinwell, Mutation Res., 329, 221-224.
8. Gorelick, N.J., J.L. Andrews, D.P. Gibson, G.J. Carr and M.J. Aardema (1996) Evaluation of lacI mutation in germ cells and micronuclei in peripheral blood after treatment of male lacI transgenic mice with ethylnitrosourea, isopropylmethane sulfonate or methylmethane sulfonate, Mutation Res., in press
9. Piegorsch, W.W., A. Lockhart, B.H. Margolin, K.R. Tindall, N.J. Gorelick, J.M. Short, G.J. Carr, E.D. Thompson and M.D. Shelby (1994) Sources of variability in data from a lacI transgenic mouse mutation assay, Environ. Mol. Mutagen., 23, 17-31.
10. Piegorsch, W.W., B.H. Margolin, M.D. Shelby, A. Johnson, J.E. French, R.W. Tennant and K.R. Tindall (1995) Study design and sample sizes for a lacI transgenic mouse mutation assay, Environ. Mol. Mutagen., 25, 231-245.
11. Piegorsch, W.W., A.C. Lockhart, G.J. Carr, B.H. Margolin, T. Brooks, G.R. Douglas, U.M. Liegibel, T. Suzuki, V. Thybaud, J.H.M. van Delft and N.J. Gorelick (1996) Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: an interlaboratory study, Mutation Res., in press.
12. Skopek, T.R., K.L. Kort and D.R. Marino (1995) Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice, Environ. Mol. Mutagen., 26, 9-15.