Importance of the hydrophobic energy: Structural determination of a hypoglycemic drug of the meglitinide family by nuclear magnetic resonance and molecular modeling

Biochemical Pharmacology

Volumn 52, Issue 8, 1996, Pages 1155-1168

  Lins, Laurence ^a   Brasseur, Robert ^a   Malaisse, Willy J ^b   Biesemans, Monique ^c   Verheyden, Patricia ^c   Willem, Rudi ^c  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

hydrophobic energy; hypoglycemic drug; molecular modeling; molecular structure; NMR

Indexed keywords

ANTIDIABETIC AGENT; MEGLITINIDE DERIVATIVE; MITIGLINIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SOLUTION; ENERGY; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

EID: 0030601830     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00424-8     Document Type: Article

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