Simultaneous high-performance liquid chromatographic analysis of flunitrazepam and four metabolites in serum

Journal of Chromatography B: Biomedical Applications

Volumn 685, Issue 2, 1996, Pages 383-387

  Berthault, F ^a   Kintz, P ^a   Mangin, P ^a  

^a INSTITUT DE MÉDECINE LÉGALE   (France)

Author keywords

3 Hydroxyflunitrazepam; 7 Aminodesmethylflunitrazepam; 7 Aminoflunitrazepam; Desmethylflunitrazepam; Flunitrazepam

Indexed keywords

7 AMINOFLUNITRAZEPAM; DRUG METABOLITE; FLUNITRAZEPAM; NORFLUNITRAZEPAM; PRAZEPAM; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MIXTURE; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TECHNIQUE;

ANTI-ANXIETY AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUNITRAZEPAM; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; PRAZEPAM; REFERENCE STANDARDS; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0030601728     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00220-4     Document Type: Article

References (8)

1. [1] R.C. Baselt and R.H. Cravey, Disposition of Toxic Drugs and Chemicals in Man, Chemical Toxicology Institute, Foster City, CA, 1995, pp. 325-327.
2. [2] Y.C. Sumiratapura, C. Aubert and J.P. Cano, Arzneim.-Forsch., 32 (1982) 252-257.
3. [3] D.J. Greenblat, H.R. Ochs, A. Locniskar and P.M. Lauven, Pharmacology, 24 (1984) 82-87.
4. [4] M.M. de Bruyne, A. Sinnema and A.M. Vermeij, Forensic Sci. Int., 24 (1984) 125-135.
5. [5] F. Benhamou-Batut, F. Demotes-Mainard and L. Labat, J. Pharm. Biomed. Anal., 12 (1994) 931-936.
6. [6] T.B. Vree and B. Linselink, J. Chromatogr., 143 (1977) 530-534.
7. [7] Y.C. Sumirtapura, C. Aubert, P. Coassolo and J.P. Cano, J. Chromatogr., 232 (1982) 111-118.
8. [8] J.P. Cano, J. Guintrand and C. Aubert, Arzneim.-Forsch., 27 (1977) 338-342.