Dual effects of endothelin-1 on the L-type Ca2+ current in ventricular cardiomyocytes

European Journal of Pharmacology

Volumn 308, Issue 3, 1996, Pages 351-355

  Kelso, Elizabeth ^a   Spiers, Paul ^a   McDermott, Barbara ^a   Scholfield, Norman ^a   Silke, Bernard ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Ca2+ current; Cardiomyocyte, ventricular; Endothelin 1

Indexed keywords

ENDOTHELIN 1;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE; INTERMETHOD COMPARISON; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RABBIT;

EID: 0030601252     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00366-4     Document Type: Article

References (14)

1. 2+ currents in cardiac cells, J. Cardiovasc. Pharmacol. 26, S293.
2. Hilal-Dandan, R., K. Urasawa and L.L. Brunton, 1992, Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes, J. Biol. Chem. 267, 10620.
3. James, A.F., L.H. Xie, Y. Fujitani, S. Hayashi and M. Horie, 1994, Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1, Nature (London) 370, 297.
4. Kelso, E.J., B.J. McDermott and B. Silke, 1995, Actions of the novel vasodilator, flosequinan, in isolated ventricular cardiomyocytes, J. Cardiovasc. Pharmacol. 25, 376.
5. 2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes, J. Physiol. 448, 729.
6. Moravec, C.S., E.E. Reynolds, R.W. Stewart and M. Bond, 1989, Endothelin is a positive inotropic agent in human and rat heart in vitro, Biochem. Biophys. Res. Commun. 159, 14.
7. Ono, K., G. Tsujimoto, A. Sakamoto, K. Eto, T. Masaki, Y. Ozaki and M. Satake, 1994, Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents, Nature (London) 370, 301.
8. Rubanyi, G.M. and M.A. Polokoff, 1994, Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology, Pharmacol. Rev. 46, 325.
9. Takenaka T., M. Epstein, H. Forster, D.W. Landry, K. Iijima and M.S. Goligorsky, 1992, Attenuation of endothelin effects by a chloride channel inhibitor, indanyloxyacetic acid, Am. J. Physiol. 262, F799.
10. Takens-Kwak, B.R., H.J. Jongsma, M.B. Rook and A.C.G. Van Ginneken, 1992, Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study, Am. J. Physiol. 262, C1531
11. 2+ current in guinea-pig heart cells, Br. J. Pharmacol. 99, 437.
12. Varro, A., P.P. Nanasi and D.A. Lathrop, 1991, Voltage-clamp characteristics of ventricular cardiomyocytes in the rabbit, Cardioscience 2, 233.
13. A-receptors couple to inositol phosphate formation and inhibition of adenytate cyclase in right atrium, J. Cardiovasc. Pharmacol. 23, 344.
14. Yanagisawa M, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, K. Goto and T. Masaka, 1988, A novel potent vasoconstrictor peptide produced by vascular endothelial cells, Nature (London) 332, 411.