Differential effect of alkyl chain-modified ether lipids on protein kinase C autophosphorylation and histone phosphorylation

Biochemical Pharmacology

Volumn 52, Issue 12, 1996, Pages 1843-1847

  Gil, Carles ^a   Molina, Elena ^a   Plana, Maria ^a   Carabaza, Assumpta ^b   Cabré, Francesc ^b   Mauleón, David ^b   Carganico, Germano ^b   Itarte, Emilio ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Research and Development   (Spain)

Author keywords

alkyl lysophospholipids; autophosphorylation; histone phosphorylation; protein kinase C

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; EDELFOSINE; EDELFOSINE DERIVATIVE; ETHER LIPID; HISTONE; PHOSPHOLIPID; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ENZYME ACTIVATION; HISTONES; PHOSPHOLIPID ETHERS; PHOSPHORYLATION; PROTAMINE KINASE; PROTEIN KINASE C; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030600590     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00519-9     Document Type: Article

References (15)

1. 1. Fos E, Suesa N, Borras L, Lobato C, Banfi P, Gambetta RA, Zunino F, Mauleón D and Carganico G, Synthesis of alkyl chain-modified ether lipids and evaluation of their in vitro cytotoxicity. J Med Chem 38: 1216-1228, 1995.
2. 2. Charp PA, Zhou Q, Wood MG, Raynor RL, Menger FM and Kuo JF, Synthetic branched-chain analogues of Distearoylphosphatidylcholine: Structure-activity relationship in inhibiting and activating protein kinase C. Biochemistry 27: 4607-4612, 1988.
3. 2+-dependent protein phosphorylation system in various types of leukaemic cells from human patients and in human leukaemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid. Cancer Res 43: 2955-2961, 1983.
4. 4. Berdel WE, Andreesen R and Munder PG, Synthetic alkyl-phospholipid analogs: A new class of antitumor agents. In: Phospholipids and Cellular Regulation (Ed. Kuo JF), pp. 41-73. CRC Press, Boca Raton, 1985.
5. 5. Basu A, The potential of protein kinase C as a target for anticancer treatment. Pharmacol Ther 59: 257-289, 1993.
6. 6. Nishizuka Y, The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308: 693-698, 1984.
7. 7. Oishi K, Raynor RL, Charp PA and Kuo JF, Regulation of protein kinase C by lysophospholipids. J Biol Chem 263: 6865-6871, 1988.
8. 8. Hofmann J, Uereball F, Posch L, Maly K, Herrmann DBJ and Grunicke H, Synergistic enhancement of the antiproliferative activity of cis-diamminedicholorplatinum (II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C. Lipids 24: 312-317, 1989.
9. 9. Marasco CJ Jr, Piantadosi C, Meyer KL, Morris-Natschke S, Ishaq KS, Small GW and Daniel LW, Synthesis and biological activity of novel quaternary ammonium derivates of alkylglycerols as potent inhibitors of protein kinase C. J Med Chem 33: 985-992, 1990.
10. 10. Morris-Natschke S, Meyer KL, Marasco CJ Jr, Piantadosi C, Rossi F, Godwin PL and Modest EJ, Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties. J Med Chem 33: 1812-1818, 1990.
11. 11. Salari H, Dryden P, Davenport R, Howard S, Jones K and Bittman R, Inhibition of protein kinase C by ether-linked lipids is not correlated with their antineoplastic activity on WEHI-3B and R6X-B15 cells. Biochim Biophys Acta 1134: 81-88, 1992.
12. 12. Newton AC and Koshland DE Jr, Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. Biochemistry 29: 6656-6661, 1990.
13. 13. Bazzi MD and Nelsestuen L, Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation. Biochemistry 26: 1974-1982, 1987.
14. 14. Kikkawa U, Go M, Koumoto J and Nishizuka Y, Rapid purification of protein kinase C by high performance liquid chromatography. Biochem Biophys Res Commun 122: 1268-1275, 1986.
15. 15. Laemmli UK, Clearage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.