Carvedilol improves function and reduces infarct size in the feline myocardium by protecting against lethal reperfusion injury

European Journal of Pharmacology

Volumn 314, Issue 1-2, 1996, Pages 99-107

  Brunvand, Harald ^a   Frøyland, Livar ^a   Hexeberg, Erik ^a   Rynning, Stein Erik ^a   Berge, Rolf K ^a   Grong, Ketil ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

carvedilol; cat; myocardial ischaemia; reperfusion injury, lethal

Indexed keywords

ANTIOXIDANT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; GLUTATHIONE; TRIPHENYLTETRAZOLIUM; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; HISTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; LETHALITY; MALE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; TISSUE LEVEL;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARBAZOLES; CATS; CORONARY VESSELS; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PROPANOLAMINES;

EID: 0030600527     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00549-3     Document Type: Article

References (38)

1. Abel, F.L., 1981, Maximal negative dP/dt as an indicator of end of systole, Am. J. Physiol. 240, H676.
2. Baller, D., H.J. Bretschneider and G. Hellige, 1981, A critical look at currently used indirect indices of myocardial oxygen consumption, Basic Res. Cardiol. 76, 163.
3. Becker, L.C. and G. Ambrosio, 1987, Myocardial consequences of reperfusion, Prog. Cardiovasc. Dis. 30, 23.
4. Birkeland, S., J. Westby, I. Hessevik, K. Grong, E. Hexeberg and J. Lekven, 1992, Compensatory subendocardial hyperkinesis in the cat is abolished during coronary insufficiency outside an acutely ischaemic region, Cardiovasc. Res. 26, 285.
5. Bolli, R., 1990, Mechanism of myocardial 'stunning', Circulation 82, 723.
6. Bolli, R., 1991, Oxygen-derived free radicals and myocardial reperfusion injury: an overview, Cardiovasc. Drugs Ther. 5, 249.
7. Bril, A., M. Slivjak, M.J. DiMartino, G.Z. Feuerstein, P. Linee, R.H. Poyser, R.R. Ruffolo Jr. and E.F. Smith III, 1992, Cardioprotective effects of carvedilol, a novel β-adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol, Cardiovasc. Res. 26, 518.
8. Brunvand, H., S.E. Rynning, E. Hexeberg, J. Westby and K. Grong, 1995, Non-uniform recovery of segment shortening during reperfusion following regional myocardial ischaemia despite uniform recovery of ATP, Cardiovasc. Res. 30, 138.
9. Engler, R. and E. Gilpin, 1989, Can superoxide dismutase alter myocardial infarct size?, Circulation 79, 1137.
10. Euler, D.E., 1995, Role of oxygen-derived free radicals in canine reperfusion arrhythmias, Am. J. Physiol. 268, H295.
11. Ferrari, R., C. Ceconi, S. Curello, O. Alfieri and O. Visioli, 1993. Myo-cardial damage during ischaemia and reperfusion, Eur. Heart J. 14 (Suppl. G), 25.
12. Feuerstein, G.Z., S.A. Hamburger, E.F. Smith III, A. Bril and R.R. Ruffolo, 1992, Myocardial protection with carvedilol, J. Cardiovasc. Pharmacol. 19 (Suppl. 1), S138.
13. Feuerstein, G.Z., T.L. Yue, H.Y. Cheng and R.R. Ruffolo Jr., 1993, Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity, J. Hypertens. 11 (Suppl. 4), S41.
14. Hamburger, S.A., F.C. Barone, G.Z. Feuerstein and R.R. Ruffolo Jr., 1991, Carvedilol (Kredex®) reduces infarct size in a canine model of acute myocardial infarction, Pharmacology 43, 113.
15. Hexeberg, E., K. Matre, S. Birkeland and J. Lekven, 1989, Non-uniforrn shortening of the anterior wall of feline left ventricles, Am. J. Physiol. 257, H1165.
16. Hexeberg, E., K. Matre and J. Lekven, 1991, Transmural fibre direction in the anterior wall of the feline left ventricle; theoretical considerations with regard to uniformity of contraction, Acta Physiol. Scand. 141, 497.
17. Hexeberg, E., S. Birkeland, K. Grong, K. Matre and J. Lekven, 1992, Coronary artery stenosis provokes non-uniformity of two-dimentional deformation in the anterior wall of the feline left ventricle, Eur. Heart J. 13, 981.
18. Heyman, M.A., B.D. Payne, J.I.E. Hoffmann and A.M. Rudolph, 1977, Blood flow measurements with radionuclide-labeled particles, Prog. Cardiovasc. Dis. 20, 55.
19. Jeroudi, M.O., C.J. Hartley and R. Bolli, 1994, Myocardial reperfusion injury: role of oxygen radicals and potential therapy with antioxidants, Am. J. Cardiol. 73, 2B.
20. 1-adrenoceptor activity on myocardial stunning in dogs, Circ. Res. 68, 1322.
21. Kloner, R.A., 1993, Does reperfusion injury exist in humans?, J. Am. Coll. Cardiol. 21, 537.
22. 1-adrenergic system and arrhythmias in ischaemic heart disease, Eur. Heart J. 12 (Suppl. F), 88.
23. Litt, M.R., R.W. Jeremy, H.F. Weisman, J.A. Winkelstein and L.C. Becker, 1989, Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia, Circulation 80, 1816.
24. Nichols, A.J., M. Gellai and R.R. Ruffolo Jr., 1991, Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol, Fund. Clin. Pharmacol. 5, 25.
25. Nichols, A.J., A.C. Sulpizio, D.J. Ashton, J.P. Hieble and R.R. Ruffolo Jr., 1989a, In vitro pharmacologic profile of the novel β-adrenoceptor antagonist and vasodilator, carvedilol, Pharmacology 39, 327.
26. 1-and β-adrenoceptors, Chirality 1, 265.
27. Opie, L.H., 1989, Reperfusion injury and its pharmacologic modification, Circulation 80, 1049.
28. Reimer, K.A., R.S. Vander Heide and V.J. Richard, 1993, Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models, Am. J. Cardiol. 72, 13G.
29. Ruffolo Jr., R.R., D.A. Boyle, R.P Venuti and M.A. Lukas, 1993, Preclinical and clinical pharmacology of carvedilol, J. Hum. Hypertens. 7 (Suppl. 1), S2.
30. Schlack, W., A. Uebing, M. Schäfer, F. Bier, S. Schaffer, H.M. Piper and V. Thamer, 1994, Regional contractile blockade at the onset of reperfusion reduces infarct size in the dog heart, Pflügers Arch. 428, 134.
31. Simpson, P.J. and B.R. Lucchesi, 1987, Free radicals and myocardial ischemia and reperfusion injury, J. Lab. Clin. Med. 110, 13.
32. Svardal, A.M., M.A. Mansoor and P.M. Ueland, 1990, Determination of reduced, oxidized and protein-bound glutathione in human plasma with precolumn derivatization with monobromobimane and liquid chromatography, Anal. Biochem. 184, 338.
33. Takeo, S., J. Liu, K. Tanonaka, Y. Nasa, K. Yabe, H. Tanahashi and H. Sudo, 1995, Reperfusion at reduced flow rates enhances postischemic contractile recovery of perfused heart, Am. J. Physiol. 268, H2384.
34. 1-adrenergic agonists precondition rabbit myocardium independent of adenosine by direct activation of protein kinase C, Circ. Res. 75, 576.
35. Willerson, J.T. and M. Buja, 1990, Protection of the myocardium during myocardial infarction: pharmacologic protection during thrombolytic-therapy, Am. J. Cardiol. 65, 351.
36. Yue, T.L., T. Liu and G.Z. Feuerstein, 1992, Carvedilol, a new vasodilator and β-adrenoceptor antagonist, inhibits oxygen-radical-mediated lipid peroxidation in swine ventricular membranes, Pharmacol. Commun. 1, 27.
37. Yue, T.L., P.J. McKenna, J.L. Gu, H.Y. Cheng, R.R. Ruffolo Jr. and G.Z. Feuerstein, 1993, Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells, Hypertension 22, 922.
38. Zahger, D., J. Yano, A. Chaux, M.C. Fishbein and W. Ganz, 1995, Absence of lethal reperfusion injury after 3 hours of reperfusion: a study in a single-canine-heart model of ischemia-reperfusion, Circulation 91, 2989.