Effects of chronic oral administration of a high dose of nicorandil on in vitro contractility of rat arterial smooth muscle

European Journal of Pharmacology

Volumn 314, Issue 1-2, 1996, Pages 83-90

  Trongvanichnam, Kamolchai ^a   Mitsui Saito, Minori ^a   Ozaki, Hiroshi ^a   Karaki, Hideaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

aorta, rat; cGMP; levcromakalim; nicorandil; relaxation; tolerance

Indexed keywords

8 BROMO CYCLIC GMP; CARBACHOL; CYCLIC GMP; FORSKOLIN; GLIBENCLAMIDE; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; ISOBUTYLMETHYLXANTHINE; LEMAKALIM; METHYLENE BLUE; NICORANDIL; NITRIC OXIDE; NITROPRUSSIDE SODIUM; NORADRENALIN; POTASSIUM CHANNEL STIMULATING AGENT; VASODILATOR AGENT; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS TOLERANCE; DRUG ANTAGONISM; DRUG MECHANISM; DRUG TOLERANCE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; THORACIC AORTA;

ADMINISTRATION, ORAL; ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NIACINAMIDE; NICORANDIL; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0030600508     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00536-5     Document Type: Article

References (41)

1. Abrams, J., 1986, Tolerance to organic nitrates, Circulation 74, 1181.
2. Ahlner, J., R.G.G. Andersson, K.L. Axelsson, U. Dahlstrom and E.L. Rydell, 1986, Development of tolerance to glyceryl trinitrate in an isolated human peripheral vein and its relation to cyclic GMP metabolism, Acta Pharmacol. Toxicol. 59, 123.
3. Ahlner, J., R.G.G. Andersson, K. Torfgard and K.L. Axelsson, 1991. Organic nitrate esters: clinical use and mechanisms of actions, Pharmacol. Rev. 43, 351.
4. Axelsson, K.L. and J. Ahlner, 1987, Nitrate tolerance from biochemical point of view Drugs 33, 63.
5. Axelsson, K.L. and R.G.G. Anderson, 1983, Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover, Eur. J. Pharmacol. 88, 71.
6. Axelsson, K.L. and J.-O.G. Karlson, 1984, Nitroglycerin tolerance in vitro: effect on cGMP turnover in vascular smooth muscle, Acta Pharmacol. Toxicol. 55, 203.
7. Endoh, M. and N. Taira, 1983, Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric arteries, Naunyn-Schmiedeberg's Arch. Pharmacol. 322, 319.
8. Flaherty, J.T., 1989, Nitrate tolerance: a review of the evidence, Drugs 37, 523.
9. Furukawa, K., I. Itoh, M. Kajiwara, K. Kitamura, H. Suzuki, Y. Ito and H. Kuriyama, 1981, Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells and on adrenergic transmission in guinea-pig and porcine mesenteric arteries, J. Pharmacol. Exp. Ther. 218, 260.
10. Galvas, P.E. and J. Disalvo, 1983, Concentration and time-dependent relationships between isosorbide dinitrate induced relaxation and formation of cyclic GMP in coronary smooth muscle, J. Pharmacol. Exp. Ther. 224, 373.
11. Henry, P.J., J.D. Horowitz and W.J. Louis, 1988, Nitroglycerin-induced tolerance affects multiple sites in the organic nitrate bioconversion cascade, J. Pharmacol. Exp. Ther. 248, 762.
12. Henry, P.J., J.D. Horowitz and W.J. Louis, 1990, Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity, J. Cardiovasc. Pharmacol. 15, 365.
13. Holzmann, S., 1983, Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil, J. Cardiovasc. Pharmacol. 5, 364.
14. Holzmann, S., W.R. Kukovetz, C. Braida and G. Poch, 1992, Molecular mechanism of action of nicorandil, Eur. J. Pharmacol. 215, 1.
15. Ignarro, L.J. and P.J. Kadowitz, 1985, The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation, Ann. Rev. Pharmacol. Toxicol. 25, 171.
16. Imagawa, J.I., M. Akima, H. Nabata and N. Taira, 1992, Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not modified by glibenclamide, J. Cardiovasc. Pharmacol. 19, 108.
17. Jiang, H., J.L. Colbran, S.H. Francis and J.D. Corbin, 1992, Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary artery, J. Biol. Chem. 267, 1015.
18. Kamolchai, T., M. Mitsui-Saito, H. Ozaki and H. Karaki, 1996a, Effects of chronic oral administration of isosorbide dinitrate on in vitro contractility of arterial smooth muscle, Jpn. J. Pharmacol. 71, 167.
19. Kamolchai, T., M. Mitsui-Saito, H. Ozaki and H. Karaki, 1996b, Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle, Eur. J. Pharmacol. 303, 39.
20. Karaki, H., K. Sato, H. Ozaki and K. Murakami, 1988, Effects of sodium nitroprusside on cytosolic calcium level in vascular smooth muscle, Eur. J. Pharmacol. 156, 259.
21. Keith, R.A., A.M. Burkman, T.D. Sokoloski and R.H. Fertel, 1982, Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle, J. Pharmacol. Exp. Ther. 221, 525.
22. Kukovetz, W.R. and S. Holzmann, 1985, Mechanisms of nitrate-induced vasodilation and tolerance on biochemical base, Z. Kardiol. 74, 39.
23. Kukovetz, W.R. and S. Holzmann, 1990, Mechanism of nitrate-induced vasodilatation and tolerance, Eur. J. Clin. Pharmacol. 38, S1.
24. Kukovetz, W.R., S. Holzmann, C. Braida and G. Poch, 1991, Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization, J. Cardiovasc. Pharmacol. 17, 627.
25. Kukovetz, W.R., S. Holzmann and G. Poch, 1992, Molecular mechanism of action of nicorandil, J. Cardiovasc. Pharmacol. 20, S1.
26. Lincoln, T.M. and R.M. Johnson, 1984, Possible role of cyclic GMP-dependent protein kinase in vascular smooth muscle function, Adv. Cycl. Nucl. Prot. Phosphor. Res. 17, 285.
27. Lincoln, T.M., 1989, Cyclic GMP and mechanisms of vasodilation, Pharmacol. Ther. 41, 479.
28. 2+ by cAMP in vascular smooth muscle, Am. J. Physiol. 258, C399.
29. + channel-dependent and cyclic GMP-dependent components in a single vascular preparation, J. Cardiovasc. Pharmacol. 17, 903.
30. Molina, C.R., J.W. Anderson, R.M. Rapoport, S. Waldman and F. Murad, 1987, Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta, J. Cardiovasc. Pharmacol. 10, 371.
31. Nabata, H., S. Shiraki and K. Sakai, 1981, Development of tolerance and a new coronary vasodilator, N-(-2-hydroxyethyl)nicotinamide nitrate (SG-75): a comparison with nitroglycerin, Jpn. J. Pharmacol. 31, 511.
32. Needleman, P., 1970, Tolerance to the vascular effects of glyceryl trinitrate, J. Pharmacol. Exp. Ther. 171, 98.
33. Needleman, P. and E.M. Johnson, 1973, Mechanism of tolerance development to organic nitrates, J. Pharmacol. Exp. Ther. 184, 709.
34. Rapoport, R.M. and F. Murad, 1983, Endothelium-dependent and nitrovasodilator induced relaxation of vascular smooth muscle: Role of cyclic GMP, J. Cycl. Nucl. Prot. Phosphor. Res. 9, 281.
35. Romanin, C. and W.R. Kukovetz, 1989, Tolerance to nitroglycerin is caused by reduced guanylate cyclase activation, J. Mol. Cell. Cardiol. 21, 41.
36. Sakai, K. and O. Kuromaru, 1987, Nitrate tolerance: Comparison of nicorandil, isosorbide dinitrate, and nitroglycerine in anesthetized dogs, J. Cardiovasc. Pharmacol. 10, S17.
37. Schultz, K.-D., E. Bohme, V.A.W. Kreye and G. Schultz, 1979, Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP, Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 1.
38. Shibata, S., 1987, New antianginal therapy: first international symposium on nicorandil, a new antianginal agent, J. Cardiovasc. Pharmacol. 10, S1.
39. Taira, N., 1987, Similarities and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: overview, J. Cardiovasc. Pharmacol. 10, S1.
40. Taira, N., 1989, Nicorandil as a hybrid between nitrates and potassium channel activators, Am. J. Cardiol. 63, 18J.
41. Thornbury, K.D., S.M. Ward, H.H. Dalziel, A. Carl, D.P. Westfall and K.M. Sanders, 1991, Nitric oxide and nitrosocycteine mimic nonadrenergic, noncholinergic hyperpolarization in canine proximal colon, Am. J. Physiol. 261, G553.