-
1
-
-
0020408957
-
Isolation and structure of bryoslatin 1
-
[1] Petit, G.R., Herald, C.L., Doubek, D.L., Arnold, E. and Clardy, J. (1982) Isolation and structure of bryoslatin 1. J. Am. Chem. Soc. 104: 6846-6848.
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 6846-6848
-
-
Petit, G.R.1
Herald, C.L.2
Doubek, D.L.3
Arnold, E.4
Clardy, J.5
-
2
-
-
0010543768
-
Bryostatin, an activator of calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic HL-60 cells
-
[2] Kraft, A.S., Smith, J.B. and Berkow, R.L. (1986) Bryostatin, an activator of calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic HL-60 cells. Proc. Nad. Acad. Sci. USA 83, 1334-1338.
-
(1986)
Proc. Nad. Acad. Sci. USA
, vol.83
, pp. 1334-1338
-
-
Kraft, A.S.1
Smith, J.B.2
Berkow, R.L.3
-
3
-
-
0023270192
-
Bryostatin induces change in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic HL-60 cells
-
[3] Kraft, A.S., Baker, V.V. and May, W.S. (1987) Bryostatin induces change in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic HL-60 cells. Oncogene 1, 111-118.
-
(1987)
Oncogene
, vol.1
, pp. 111-118
-
-
Kraft, A.S.1
Baker, V.V.2
May, W.S.3
-
4
-
-
0026067787
-
Selective translocation of βII-protein kinase C to the nucleus of human promeylocytic (HL-60) leukemia cells
-
[4] Hocevar, B.A. and Fields, A.P. (1991) Selective translocation of βII-protein kinase C to the nucleus of human promeylocytic (HL-60) leukemia cells. J. Biol. Chem. 266, 28-33.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 28-33
-
-
Hocevar, B.A.1
Fields, A.P.2
-
5
-
-
0028055160
-
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
-
[5] Szallasi, Z., Smith, C.B., Pettit, G.R. and Blumberg, P.M. (1994) Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 269, 2118-2124.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2118-2124
-
-
Szallasi, Z.1
Smith, C.B.2
Pettit, G.R.3
Blumberg, P.M.4
-
6
-
-
0000257856
-
-
(Herz, W., Kerby, G.W., Steglich, W. and Tamm, C., eds.), Springer Verlag, Vienna
-
[6] Pettit, G.R. (1991) in: The bryostatins. Progress in the Chemistry of Organic Natural Products, Vol. 57 (Herz, W., Kerby, G.W., Steglich, W. and Tamm, C., eds.), pp. 152-193, Springer Verlag, Vienna.
-
(1991)
The Bryostatins. Progress in the Chemistry of Organic Natural Products
, vol.57
, pp. 152-193
-
-
Pettit, G.R.1
-
7
-
-
0025961690
-
Successful treatment of murine melanoma with bryostatin 1
-
[7] Schuchter, L.M., Esa, A.H., May, W.S., Laulis, M.K., Pettit, G.R. and Hess, A.D. (1991) Successful treatment of murine melanoma with bryostatin 1. Cancer Res. 51, 682-687.
-
(1991)
Cancer Res.
, vol.51
, pp. 682-687
-
-
Schuchter, L.M.1
Esa, A.H.2
May, W.S.3
Laulis, M.K.4
Pettit, G.R.5
Hess, A.D.6
-
8
-
-
0026532012
-
Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: In vitro versus in vivo activity
-
[8] Hornung, R.L., Pearson, J.W., Beckwith, M. and Longo, D.L. (1992) Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity. Cancer Res. 52, 101-107.
-
(1992)
Cancer Res.
, vol.52
, pp. 101-107
-
-
Hornung, R.L.1
Pearson, J.W.2
Beckwith, M.3
Longo, D.L.4
-
9
-
-
0025264496
-
Bryostatin 1, a unique biologic response modifier: Antileukemic activity in vitro
-
[9] Jones, R.J., Sharkis, S.J., Miller, C.B. and Rowinsky, E.K. (1990) Bryostatin 1, a unique biologic response modifier: antileukemic activity in vitro. Blood 75, 1319-1323.
-
(1990)
Blood
, vol.75
, pp. 1319-1323
-
-
Jones, R.J.1
Sharkis, S.J.2
Miller, C.B.3
Rowinsky, E.K.4
-
10
-
-
0027488490
-
Bryostatin 1: Will the oceans provide a cancer cure?
-
[10] Kraft, A.S. (1993) Bryostatin 1: Will the oceans provide a cancer cure? J.N.C.I. 85, 1790-1792.
-
(1993)
J.N.C.I.
, vol.85
, pp. 1790-1792
-
-
Kraft, A.S.1
-
11
-
-
0027489606
-
Phase I study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor a induction in vivo
-
[11] Philip, P.A., Rea, D., Thavasu, P., Carmichael, J., Stuart, N.S.A., Rockett, H., Talbot, D.C., Ganesan, T., Pettit, G.R., Balkwill, R. and Harris, A.L. (1993) Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor a induction in vivo. J.N.C.I. 85, 1812-1818.
-
(1993)
J.N.C.I.
, vol.85
, pp. 1812-1818
-
-
Philip, P.A.1
Rea, D.2
Thavasu, P.3
Carmichael, J.4
Stuart, N.S.A.5
Rockett, H.6
Talbot, D.C.7
Ganesan, T.8
Pettit, G.R.9
Balkwill, R.10
Harris, A.L.11
-
12
-
-
0023502487
-
Co-induction of lymphokine synthesis by the antineoplastic bryostatin
-
[12] Hess, A.D., Pettit, G.R. and Plessing-Menze, A. (1987) Co-induction of lymphokine synthesis by the antineoplastic bryostatin. Immunobiology 175, 420-430.
-
(1987)
Immunobiology
, vol.175
, pp. 420-430
-
-
Hess, A.D.1
Pettit, G.R.2
Plessing-Menze, A.3
-
13
-
-
0023865665
-
Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins
-
[13] Trenn, G., Pettit, G.R., Takayama, H., et al. (1988) Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins. J. Immunol. 140, 433-439.
-
(1988)
J. Immunol
, vol.140
, pp. 433-439
-
-
Trenn, G.1
Pettit, G.R.2
Takayama, H.3
-
14
-
-
0026573371
-
Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1
-
[14] Tuttle, T.M., Inge, T.H., Bethke, K.P., et al. (1992) Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1. Cancer Res. 52, 548-553.
-
(1992)
Cancer Res.
, vol.52
, pp. 548-553
-
-
Tuttle, T.M.1
Inge, T.H.2
Bethke, K.P.3
-
15
-
-
0027326957
-
A phase I study of intravenous bryostatin 1 in patients with advanced cancer
-
[15] Prendiville, J., Crowther, D., Thatcher, N., et al. (1994) A phase I study of intravenous bryostatin 1 in patients with advanced cancer. Br. J. Cancer 68, 418-424.
-
(1994)
Br. J. Cancer
, vol.68
, pp. 418-424
-
-
Prendiville, J.1
Crowther, D.2
Thatcher, N.3
-
17
-
-
0026783265
-
The regulatory domain of protein kinase C coordinates four atoms of zinc
-
[17] Quest, A.F., Bloomenthal, J., Bardes, E.S. and Bell, R.M. (1992) The regulatory domain of protein kinase C coordinates four atoms of zinc. J. Biol. Chem. 267, 10193-10197.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 10193-10197
-
-
Quest, A.F.1
Bloomenthal, J.2
Bardes, E.S.3
Bell, R.M.4
-
18
-
-
0026704406
-
Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation
-
[18] Franklin, C.C., Sanchez, V., Wagner, F., Woodgett, J.R. and Kraft, A.S. (1992) Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. Proc. Natl, Acad. Sci. USA 89, 7247-7251.
-
(1992)
Proc. Natl, Acad. Sci. USA
, vol.89
, pp. 7247-7251
-
-
Franklin, C.C.1
Sanchez, V.2
Wagner, F.3
Woodgett, J.R.4
Kraft, A.S.5
-
19
-
-
0025089395
-
Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation
-
[19] William, F., Wagner, F., Karin, M. and Kraft, A.S. (1990) Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation. J. Biol. Chem. 265, (1816)6-(1817)1.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18166-18171
-
-
William, F.1
Wagner, F.2
Karin, M.3
Kraft, A.S.4
-
20
-
-
0021333236
-
A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer
-
[20] Ingerman-Wojenski, C.M. and Silve, M.J.A. (1984) A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. Thromb. Haemostasis, 51, 154-156.
-
(1984)
Thromb. Haemostasis
, vol.51
, pp. 154-156
-
-
Ingerman-Wojenski, C.M.1
Silve, M.J.A.2
-
21
-
-
0017385710
-
The lum-aggregometer a new instrument for simulataneous measurement of secretion and aggregation by platelets
-
[21] Feinman, R.D., Lubowsky, J., Charo, I. and Zabinski, M.P. (1977) The lum-aggregometer a new instrument for simulataneous measurement of secretion and aggregation by platelets. J. Lab. Clin. Med. 90, 125-129.
-
(1977)
J. Lab. Clin. Med.
, vol.90
, pp. 125-129
-
-
Feinman, R.D.1
Lubowsky, J.2
Charo, I.3
Zabinski, M.P.4
-
22
-
-
84989060143
-
1H and 13C NMR assignments of the antitumor macrolide bryostatin 1
-
[22] Schaufelberger, D.E., Chmurny, G.N. and Kolek, M.P. (1991) 1H and 13C NMR assignments of the antitumor macrolide bryostatin 1. Mag. Res. Chem. 2, 366-374.
-
(1991)
Mag. Res. Chem.
, vol.2
, pp. 366-374
-
-
Schaufelberger, D.E.1
Chmurny, G.N.2
Kolek, M.P.3
-
23
-
-
85030208388
-
-
Water soluble derivatives of taxol. U.S. Patent #5059,699
-
[23] Kingston, D.G.I. and Zhao, Z.-Y. Water soluble derivatives of taxol. U.S. Patent #5059,699.
-
-
-
Kingston, D.G.I.1
Zhao, Z.-Y.2
-
24
-
-
0024253756
-
Direct interaction between fos and jun nuclear oncoproteins: Role of the leucine zipper domain
-
[24] Sassone-Corsi, P., Ransome, L.J., Lamph, W.W. and Verma, I.M. (1988) Direct interaction between fos and jun nuclear oncoproteins: role of the leucine zipper domain. Nature 336, 692-695.
-
(1988)
Nature
, vol.336
, pp. 692-695
-
-
Sassone-Corsi, P.1
Ransome, L.J.2
Lamph, W.W.3
Verma, I.M.4
-
25
-
-
0023782359
-
The c-fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes
-
[25] Chiu, R. Boyle, W.J., Meek, J., Smeal, T., Hunter, T. and Karin, M. (1988) The c-fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54, 541-552.
-
(1988)
Cell
, vol.54
, pp. 541-552
-
-
Chiu, R.1
Boyle, W.J.2
Meek, J.3
Smeal, T.4
Hunter, T.5
Karin, M.6
-
26
-
-
0026799441
-
Affinity-purified c-Jun amino-lerminal protein kinase requires serine/threonine phosphorylation for activity
-
[26] Adler, V., Polotskaya, A., Wagner, F. and Kraft, A.S. Affinity-purified c-Jun amino-lerminal protein kinase requires serine/threonine phosphorylation for activity. J. Biol. Chem. 267, 17001-17005.
-
J. Biol. Chem.
, vol.267
, pp. 17001-17005
-
-
Adler, V.1
Polotskaya, A.2
Wagner, F.3
Kraft, A.S.4
-
27
-
-
0028329953
-
Jnkl: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
[27] Derijard, B., Hibi, M., Wu, I-H, Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R.J. (1994) Jnkl: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.-H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
28
-
-
0028229012
-
The stressactivated protein kinase subfamily of c-Jun kinases
-
[28] Kyriakis, J.M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E.A., Ahmad, M.R., Avruch, J. and Woodgett, J.R. (1994) The stressactivated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.
-
(1994)
Nature
, vol.369
, pp. 156-160
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.R.6
Avruch, J.7
Woodgett, J.R.8
-
29
-
-
0024284824
-
Common DNA binding site for fos protein complexes and transcription factor AP-1
-
[29] Rauscher, F.J.. III, Sambucetti, L.C., Curran, T., Distel, R.J. and Spiegelman, B.M. Common DNA binding site for fos protein complexes and transcription factor AP-1. Cell (1988) 52, 471-480.
-
(1988)
Cell
, vol.52
, pp. 471-480
-
-
Rauscher F.J. III1
Sambucetti, L.C.2
Curran, T.3
Distel, R.J.4
Spiegelman, B.M.5
-
30
-
-
0027315073
-
In vivo adminsitration of the anticancer agent bryostatin 1 activates platelets and neturophils and modulates protein kinase C activity
-
[30] Berkow, R.L., Schlabach, L., Dodson, R., Benjamin, W.H., Pettit, G.R., Rustagi, P. and Kraft, A.S. (1993) In vivo adminsitration of the anticancer agent bryostatin 1 activates platelets and neturophils and modulates protein kinase C activity. Cancer Res, 53, 2810-2815.
-
(1993)
Cancer Res
, vol.53
, pp. 2810-2815
-
-
Berkow, R.L.1
Schlabach, L.2
Dodson, R.3
Benjamin, W.H.4
Pettit, G.R.5
Rustagi, P.6
Kraft, A.S.7
-
31
-
-
0029655944
-
Comparison of the antitumor activity of bryostatins 1,5, and 8
-
in press
-
[31] Kraft, A.S., Woodley, S., Pettit, G.R., Gao, F., Coll, J.C. and Wagner, F. (1996) Comparison of the antitumor activity of bryostatins 1,5, and 8. Cancer Chem. and Pharm., in press.
-
(1996)
Cancer Chem. and Pharm.
-
-
Kraft, A.S.1
Woodley, S.2
Pettit, G.R.3
Gao, F.4
Coll, J.C.5
Wagner, F.6
-
32
-
-
0000204755
-
Isolation and structure of bryostatins 12 and 13
-
[32] Pettit, G.R., Lett, J.W., Herald, C.L., Kamano, Y., Boettner, F.E., Baczynskyj, L. and Nieman, R.A. (1987) Isolation and structure of bryostatins 12 and 13. J. Org. Chem. 52, 2854-2860.
-
(1987)
J. Org. Chem.
, vol.52
, pp. 2854-2860
-
-
Pettit, G.R.1
Lett, J.W.2
Herald, C.L.3
Kamano, Y.4
Boettner, F.E.5
Baczynskyj, L.6
Nieman, R.A.7
-
33
-
-
0038029470
-
Drug access and prodrugs
-
(Ganellin, C.R. and Roberts, S.M. eds), Academic Press, San Diego, CA
-
[33] Collis, A.J. (1992) in: Drug access and prodrugs. Medicinal Chem istry. 2nd edn. (Ganellin, C.R. and Roberts, S.M. eds), pp. 61-82. Academic Press, San Diego, CA.
-
(1992)
Medicinal Chem Istry. 2nd Edn.
, pp. 61-82
-
-
Collis, A.J.1
-
34
-
-
0023905721
-
Modified taxols, 4. Synthesis and bilogical activity of taxols modified in the side chain
-
[34] Magri, N.F. and Kingston, D.G. (1988) Modified taxols, 4. Synthesis and bilogical activity of taxols modified in the side chain. J. Natl. Prod. 51, 298-306.
-
(1988)
J. Natl. Prod.
, vol.51
, pp. 298-306
-
-
Magri, N.F.1
Kingston, D.G.2
-
35
-
-
0024597827
-
Synthesis of Congeners and Prodrugs. X. Water-soluble prodrugs of taxol with potent antitumor activity
-
[35] Deutsch, H.M., Gliniski, J.A., Hernandez, M., Haugwitz, R.D., Narayanan, V.L., Suffness, M. and Zalkow, L.H. (1989) Synthesis of Congeners and Prodrugs. X. Water-soluble prodrugs of taxol with potent antitumor activity. J. Med. Chem. 32, 788-792.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 788-792
-
-
Deutsch, H.M.1
Gliniski, J.A.2
Hernandez, M.3
Haugwitz, R.D.4
Narayanan, V.L.5
Suffness, M.6
Zalkow, L.H.7
-
36
-
-
0000852678
-
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C
-
[36] Wender, P.A., Cribbs, C.M., Koehler, K.F., Sharkey, N.A., Herald, C.L., Kamano, Y., Pettit, G.R. and Blumberg, P.M. (1988) Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc. Natl. Acad. Sci. USA 85, 7197-7201.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 7197-7201
-
-
Wender, P.A.1
Cribbs, C.M.2
Koehler, K.F.3
Sharkey, N.A.4
Herald, C.L.5
Kamano, Y.6
Pettit, G.R.7
Blumberg, P.M.8
-
37
-
-
0028055160
-
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
-
[37] Szallasi, Z., Smith, C.B., Pettit, G.R. and Blumberg, P.M. (1994) Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 269, 2118-2124.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2118-2124
-
-
Szallasi, Z.1
Smith, C.B.2
Pettit, G.R.3
Blumberg, P.M.4
-
38
-
-
0027467498
-
Protein kinase C activation without membrane contact in platelets stimulated by bryostatin
-
[38] Grabarek, J. and Ware, J.A. (1993) Protein kinase C activation without membrane contact in platelets stimulated by bryostatin. J. Biol. Chem. 268, 5543-5549.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5543-5549
-
-
Grabarek, J.1
Ware, J.A.2
-
39
-
-
0026704406
-
Phorbol ester-induced amino-terminal phosphorylation of human Jun but not JunB regulates transcriptional activation
-
[39] Franklin, C.C., Sanchez, V., Wagner, F., Woodgett, J.R. and Kraft, A.S. (1992) Phorbol ester-induced amino-terminal phosphorylation of human Jun but not JunB regulates transcriptional activation. PNAS 89, 7247-7251.
-
(1992)
PNAS
, vol.89
, pp. 7247-7251
-
-
Franklin, C.C.1
Sanchez, V.2
Wagner, F.3
Woodgett, J.R.4
Kraft, A.S.5
-
40
-
-
0023749283
-
Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells
-
[40] Stone, R.M., Sariban, E., Pettit, G.R. and Kufe, D.W. (1988) Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood 72, 208-213.
-
(1988)
Blood
, vol.72
, pp. 208-213
-
-
Stone, R.M.1
Sariban, E.2
Pettit, G.R.3
Kufe, D.W.4
-
41
-
-
0020698115
-
Phorbol esters increase the amount of calcium, phospholipid-dependent protein kinase associated with plasma membrane
-
[41] Kraft, A.S. and Anderson, W.B. (1983) Phorbol esters increase the amount of calcium, phospholipid-dependent protein kinase associated with plasma membrane. Nature 301, 621-623.
-
(1983)
Nature
, vol.301
, pp. 621-623
-
-
Kraft, A.S.1
Anderson, W.B.2
|