Total synthesis of arcyroxocin A

Tetrahedron Letters

Volumn 37, Issue 26, 1996, Pages 4483-4486

  Mayer, Guido ^a   Wille, Gregor ^a   Steglich, Wolfgang ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARCYROXOCIN A; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; ISOLATION PROCEDURE; STRUCTURE ANALYSIS;

EID: 0030600181     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00864-7     Document Type: Article

References (15)

1. 1 Pigments of Fungi, 66. Part 65: Hopmann, C.; Steglich, W. Liebigs Ann. 1996, in press.
2. 2. I. Casser, Dissertation, University of Bonn, 1986; compare also: Gill, M.; Steglich, W. Prog. Chem. Org. Nat. Prod. 1987, 51, 216-226; Steglich, W. Pure & Appl. Chem. 1989, 61, 281-288.
3. 2. I. Casser, Dissertation, University of Bonn, 1986; compare also: Gill, M.; Steglich, W. Prog. Chem. Org. Nat. Prod. 1987, 51, 216-226; Steglich, W. Pure & Appl. Chem. 1989, 61, 281-288.
4. 2. I. Casser, Dissertation, University of Bonn, 1986; compare also: Gill, M.; Steglich, W. Prog. Chem. Org. Nat. Prod. 1987, 51, 216-226; Steglich, W. Pure & Appl. Chem. 1989, 61, 281-288.
5. 3. Review: Gribble, G. W.; Berthel, S. J. Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Vol. 12, 365-409; Elsevier Science Publishers, Amsterdam, 1993.
6. 4. Brenner, M.; Rexhausen, H.; Steffan, B.; Steglich W. Tetrahedron 1988, 44, 2887-2892.
7. 5. 4-(Tetrahydropyranyloxy)indole was obtained in 45% yield in four steps from 2-methyl-3-nitroaniline in analogy to the procedure for 6-methoxyindole: Feldmann, P. L.; Rapoport, H. Synthesis 1979, 735-737.
8. 5 calc.: 457.1634, found.: 457.1611.
9. 7. Bongini, A.; Cardillo, G.; Orena, M.; Sandri, S. Synthesis 1979, 618-620.
10. 8. Compare: Bergman, J.; Pelcman, B. Tetrahedron Lett. 1987, 28, 4441-4444.
11. +] (3), 400 (1), 399 (3), 356 (7), 355 (10).
12. 10. Rawal, V. H.; Cava, M. P. Tetrahedron Lett. 1985, 26, 6141-6142.
13. 11. Apelqvist, T.; Wensbo, D. Tetrahedron Lett. 1996, 37, 1471-1472.
14. 12. Davis, P. D.; Bit, R. A. Tetrahedron Lett. 1990, 31, 5201-5204.
15. 3 calcd.: 341.0800, found: 341.0778.