A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

Tetrahedron Letters

Volumn 37, Issue 52, 1996, Pages 9317-9320

  Kang, Soon Bang ^a   Ahn, Eu Jin ^a   Kim, Youseung ^a   Kim, Yong Hae ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZINE DERIVATIVE; LEVOFLOXACIN;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; REACTION ANALYSIS;

EID: 0030599670     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)82952-8     Document Type: Article

References (26)

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17. 12
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22. 2, in 76% yield. (formula presented)
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24. += 281) derived from the benzoxazine derivative 2 and trifluoroacetic anhydride using 50 m × 0.32 mm I.D. PERMABOND L-CHIRASIL-VAL fused silica capillary column with FID. The retention times of 2 and its enantiomer were 62.121 min and 62.798 min, respectively.
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