Molecular analyses of liver tumors in c-myc transgenic mice and c-myc and TGF-α double transgenic mice

Cancer Letters

Volumn 106, Issue 1, 1996, Pages 43-49

  Ohgaki, Hiroko ^a,b   Sanderson, Nancy D ^a   Ton, Phuongnga ^a   Thorgeirsson, Snorri S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

c myc; Insulin like growth factor II; Liver tumor; Transforming growth factor ; Transgenic mice

Indexed keywords

ALBUMIN; SOMATOMEDIN B; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER CARCINOGENESIS; LIVER TUMOR; MALE; NONHUMAN; ONCOGENE C MYC; ONCOGENE H RAS; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMALIA; MUS MUSCULUS;

EID: 0030598977     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04299-1     Document Type: Article

References (31)

1. [1] Murakami, H., Sanderson, N.D., Nagy, P., Marino, P., Merlino, G. and Thorgeirsson, S.S. (1993) Transgenic mouse model for synergistic effects of nuclear oncogene and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor α in hepatic oncogenesis. Cancer Res., 53, 1719-1723.
2. [2] Takagi, H., Sharp, R., Hammermeister, C., Doodrow, T., Bradley, M.O., Fausto, N. and Merlino, G. (1992) Molecular and genetic analysis of liver oncogenesis in transforming growth factor a transgenic mice. Cancer Res., 52, 5171-5177.
3. [3] Tabor, E. (1994) Tumor suppressor genes, growth factor genes, and oncogenes in hepatitis B virus-associated hepatocellular carcinoma. J. Med. Virol., 42, 357-365.
4. [4] Schaff, Z., Hsia, C.C., Sarosi, I. and Tabor, E. (1994) Overexpression of transforming growth factor-α in hepatocellular carcinoma and focal nodular hyperplasia from European patients. Hum. Pathol., 25, 644-651.
5. [5] Greenblatt, M.S., Bennett, W.P., Hollstein, M. and Harris, C.C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878.
6. [6] Sandgren, E.P., Luetteke, N.C., Qiu, T.H., Palmiter, R.D., Brinster, R.L, and Lee, D.C. (1993) Transforming growth factor α dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol. Cell. Biol., 13, 320-330.
7. [7] Jhappan, C., Stahle, C., Harkins, R.N., Fausto, N., Smith, G.H. and Merlino, G.T. (1990) TGF-α overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61, 1137-1146.
8. [8] Lee, G.-H., Merlino, G. and Fausto, N. (1992) Development of liver tumors in transforming growth factor α transgenic mice. Cancer Res., 52, 5162-5170.
9. [9] Schirmacher, P., Held, W.A., Chisari, Y.F.V., Rustum, Y. and Rogler, C.E. (1992) Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res., 52, 2549-2556.
10. [10] Fox, T.R., Schumann, A.M., Watanabe, P.G., Yano, B.L,. Maher, V.M. and McCormick, J.J. (1990) Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 X C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens. Cancer Res., 50, 4014-4019.
11. [11] Richardson, K.K., Helvering, L.M., Copple, D.M., Rexroat, M.A., Linville, D.W., Engelhardt, J.A., Todd, G.C. and Richardson, F.C. (1992) Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986. Carcinogenesis, 13, 935-941.
12. [12] Anna, C.H., Maronpot, R.R., Pereira, M.A., Foley, J.F., Malarkey, D.E. and Anderson, M.W. (1994) ras protooncogene activation in dichloroacetic acid-trichloroethylene-and tetrachloroethylene-induced liver tumors in B6C3F1 mice. Carcinogenesis, 15, 2255-2261.
13. [13] Chen, B., Liu, L., Castonguay, A., Maronpot, R.R., Anderson, M.W. and You, M. (1993) Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors. Carcinogenesis, 14, 1603-1608.
14. [14] Evarts, R.P., Nagy, P., Marsden, E. and Thorgeirsson, S.S. (1987) In situ hybridization studies on expression of albumin and α-fetoprotein during the early stage of neoplastic transformation in rat liver. Cancer Res., 47, 5497-5475.
15. [15] Ohgaki, H., Kleihues. P. and Hard, G.C. (1991) Ki-rax Mutations in spontaneous and chemically induced renal tumors of the rat. Mol. Carcinogenesis, 4, 455-459.
16. [16] Brathwaite, O., Bayona, W. and Newcomb, E.W. (1992) p53 mutations in C57BL/6J murine thymic lymphomas induced by gamma-irradiation and N-methylnitrosourea. Cancer Res., 52, 3791-3795.
17. [17] Froesch, E.R., Schmid, C., Schwander, J. and Zapf, J. (1985) Action of insulin-like growth factors. Annu. Rev. Physiol., 47, 443-467.
18. [18] Irminger, J.C., Rosen, K.M., Humbel, R.E. and Villa-Komaroff, L. (1987) Tissue specific expression of insulin-like growth factor II mRNAs distinct 5′ untranslated regions. Proc. Natl. Acad. Sci. USA, 84, 6330-6334.
19. [19] Cariani, E., Lasserre, C., Seurin, D., Hamelin, B., Kemeny, F., Franco, D., Czech, M.P., Ullrich, A. and Brechet, C. (1988) Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis. Cancer Res., 48, 6844-6849.
20. [20] Norstedt, G., Levinovitz, A., Moller, C., Ericksson, L.C. and Andersson, G. (1988) Expression of insulin-like growth factor I (IGF-I) and IGF-II mRNA during hepatic development, proliferation and Carcinogenesis in the rat. Carcinogenesis, 9, 209-213.
21. [21] Fu, X.-X., Su, C.Y., Lee, Y., Hintz, R., Biempica, L., Snyder, R. and Rogler, C.E. (1988) Insulin-like growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers. J. Virol., 62, 3422-3430.
22. [22] Yang, D. and Regler, C.E. (1991) Analysis of insulin-like growth factor II (IGF-II) expression in neoplastic nodules and hepatocellular carcinomas of woodchucks utilizing in situ hybridization and immunocytochemistry. Carcinogenesis, 12, 1893-1901.
23. [23] Regler, C.E., Hino, O. and Su, C.Y. (1987) Molecular aspects of persistent woodchuck hepatitis virus and hepatitis B virus infection and hepatocellular carcinoma, Hepatology, 7, 74S-78S.
24. [24] Cariani, E., Dubois, N., Lasserre, C., Briand, P. and Brechot, C. (1991) Insulin-like growth factor II (IGF-II): mRNA expression during hepatocarcinogenesis in transgenic mice. J. Hepatol., 13, 220-226.
25. [25] Rogler, C.E., Yang, D., Rossetti, L., Donohoe, J., Alt, E., Chang, C.J., Rosenfeld, R., Neely, K. and Hintz, R. (1994) Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J. Biol. Chem., 269, 13779-13784.
26. [26] Evan, G.I., Wyllie, A.H., Gilbert, C.S., Littlewood, T.D., Land, H., Brooks, M., Waters, CM., Penn, L.Z. and Hancock, D.C. (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69, 119-128.
27. [27] Williams, G.T. and Smith, C.A. (1993) Molecular regulation of apoptosis: genetic control on cell death. Cell, 74, 777-779.
28. [28] Adams, J.M., Harris, A.W., Pinkert, C.A., Corcoran, L.M., Alexander, W.S., Cory, S., Palmiter, R.D. and Brinster, R.L. (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature, 318, 533-538.
29. [29] DePinho, R.A., Schreiber-Agus, N. and Alt, F.W. (1991) myc family oncogenes in the development of normal and neoplastic cells. Adv. Cancer Res., 57, 1-46.
30. [30] Grignani, F., Lombardi, L., Inghirami, G., Sternas, L., Cechova, K. and Dalla-Favera, R. (1990) Negative autoregulation of c-myc gene expression is inactivated in transformed cells. EMBO J., 9, 3913-3922.
31. [31] Lee, G.-H., Li, H., Ohtake, K., Nomura, K., Hino, O., Furuta, Y., Aizawa, S. and Kitagawa, T. (1990) Detection of activated c-H-ras oncogene in hepatocellular carcinomas developing in transgenic mice harboring albumin promoter-regulated Simian virus 40 gene. Carcinogenesis, 11, 1145-1148.