V(D)J recombination is regulated similarly in RAG-transfected fibroblasts and pre-B cells

Journal of Molecular Biology

Volumn 261, Issue 3, 1996, Pages 309-314

  Döbbeling, Udo ^a,b   Hobi, Reinhard ^a   Berchtold, Martin W ^a   Kuenzle, Clive C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Intracellular signalling; Molecular immunology; RAG genes; Regulation; V(D)J recombination

Indexed keywords

CALCIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PROTEIN KINASE C;

ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA TRANSFECTION; FIBROBLAST CULTURE; GENE; GENETIC RECOMBINATION; IMMUNOGLOBULIN GENE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0030598971     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0462     Document Type: Editorial

References (28)

1. H fusions. Proc. Natl Acad. Sci. USA, 79, 4118-4122.
2. Alt, F., Rosenberg, N., Lewis, S., Thomas, E. & Baltimore, D. (1981). Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell, 27, 381-390.
3. Angel, P., Hattori, K., Smeal, T. & Karin, M. (1988). The jun proto-oncogene is positively autoregulated by its product. Cell, 55, 875-885.
4. Angel, P., Smeal, T., Meek, J. & Karin, M. (1989). Jun and v-jun contain multiple regions that participate in transcription activation in an independent manner. New Biol. 1, 35-43.
5. Birnboim, C. & Doly, J. (1979). A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucl. Acids Res. 7, 1513-1523.
6. Boise, H. L., Petryniak, P., Mao, X., June, C. H., Wang, C.-Y., Lindsten, T., Bravo, R., Kovary, K., Leiden, D. W. & Thompson, C. B. (1993). The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol. Cell. Biol. 13, 1911-1919.
7. Chiu, R., Boyle, W. J., Meek, J., Smeal, T., Hunter, T. & Karin, M. (1988). The c-fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell, 54, 541-552.
8. Chiu, R., Angel, P. & Karin, M. (1989). JunB differs in its biological properties from, and is a negative regulator of, c-jun. Cell, 59, 979-986.
9. Deng, T. & Karin, M. (1993). JunB differs from c-jun in its DNA-binding and dimerization domains, and represses c-jun by formation of inactive heterodimers. Genes Dev. 7, 479-490.
10. Gonzales, G. A. & Montminy, M. R. (1989). Cyclic cAMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell, 59, 675-680.
11. Hesse, J. E., Lieber, M. R., Gellert, M. & Mizuuchi, K. (1987). Extrachromosomal DNA substrates in pre B-cells undergo inversion or deletion at immunoglobulin V(D)J recombination joining signals. Cell, 49, 775-783.
12. Inoue, H., Nojima, H. & Okayama, H. (1990). High efficiency transformation of Escherichia coli with plasmids. Gene, 96, 23-28.
13. Jain, J., McCaffrey, P. G., Valge-Archer, V. E. & Rao, A. (1992). Nuclear factor of activated T cells contains fos and jun. Nature, 356, 801-804.
14. Kallenbach, S., Goodhardt, M. & Rougeon, F. (1990). A rapid test for V(D)J recombinase activity. Nucl. Acids Res. 18, 6730.
15. Lin, W.-C. & Desiderio, S. (1993). Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science, 260, 953-959.
16. Lin, W.-C. & Desiderio, S. (1994). Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc. Natl Acad. Sci. USA, 91, 2733-2737.
17. Menetski, J. P. & Gellert, M. (1990). V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP. Proc. Natl Acad. Sci. USA, 87, 9324-9328.
18. Neale, G. A. M., Fitzgerald, T. J. & Goorha, R. M. (1992). Expression of the V(D)J recombinase gene rag-1 is tightly regulated and involves both transcriptional and post-transcriptional controls. Mol. Immunol. 29, 1457-1466.
19. Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. (1990). Rag-1 and rag-2, adjacent genes that synergistically activate V(D)J recombination. Science, 248, 1517-1523.
20. H gene segment rearrangements in lymphoid cells. Nature, 312, 418-423.
21. Schatz, D. G. & Baltimore, D. (1988). Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell, 53, 107-115.
22. Schatz, D. G., Oettinger, M. A. & Baltimore, D. (1989). The V(D)J recombination activating gene, RAG-1. Cell, 59, 1035-1048.
23. 2/ATPase inhibitor thapsigargin. Proc. Natl Acad. Sci. USA, 88, 7096-7100.
24. Takahama, Y. & Singer, A. (1992). Post-transcriptional regulation of early T-cell development by T-cell receptor signals. Science, 258, 1456-1462.
25. Uhler, M. D. & McKnight, G. S. (1987). Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem. 262, 15202-15207.
26. Ullman, K. S., Northrop, J. P., Admon, A. & Crabtree, G. R. (1993). Jun family members are controlled by calcium-regulated, cyclosporin A sensitive pathways in activated T lymphocytes. Genes Dev. 7, 188-196.
27. Wasylyk, B., Wasylyk, C., Flores, P., Bergue, A., Leprince, D. & Stehelin, D. (1990). The c-ets proto-oncogenes encode transcription factors that cooperate with c-fos and c-jun for transcriptional activation. Nature, 346, 191-193.
28. Westin, G., Gerster, T., Müller, M. M., Schaffner, G. & Schaffner, W. (1987). OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucl. Acids Res. 15, 6787-6798.