The effects of electric fields on photosensitized erythrocytes: Possible enhancement of photodynamic activation

Cancer Letters

Volumn 106, Issue 1, 1996, Pages 69-74

  Ward, T ^a   Rollan, A ^a   Flynn, G ^b   McHale, A P ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Cancer; Electric; Erythrocytes; Hematoporphyrin derivative; Photodynamic therapy; Pulses

Indexed keywords

HEMATOPORPHYRIN DERIVATIVE; PHOTOSENSITIZING AGENT;

ARTICLE; CONTROLLED STUDY; CYTOLYSIS; ELECTRIC FIELD; ELECTROSTIMULATION; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL;

EID: 0030598933     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04302-9     Document Type: Article

References (10)

1. [1] Pope, A.J. and Bown, S.G. (1991) Photodynamic therapy. Br. J. Urol., 68, 1-9.
2. [2] Rosenthal, D.I. and Galtstein, E. (1994) Clinical applications of photodynamic therapy. Ann. Med., 26, 405-409.
3. [3] Flynn, G., McHale, L. and McHale, A.P. (1994) Methotrexate-loaded, photosensitized erythrocytes: a photo-activatable carrier/delivery system for use in cancer therapy. Cancer Lett., 82, 225-229.
4. [4] McHale, A.P., McHale L. and Blau, W. (1988) The effect of hematoporphyrin derivative and human erythrocytes encapsulated hematoporphyrin derivative on a mouse myeloma cell line. Cancer Biochem. Biophys., 10, 157-164.
5. [5] Flynn, G., Hackett, T.J., McHale, L. and McHale, A.P. (1994) Encapsulation of the thrombolytic enzyme, brinase, in photosensitized erythrocytes: a novel thrombolytic system bases on photodynamic activation. J. Photochem. Photobiol. B (Biol.), 26, 193-196.
6. [6] Mir., L.M., Orlowski, S. and Heller, R. (1995) Biomedical application of electric pulses with special emphasis on antitumor electochemotherapy. Bioelectrochem. Bioenerg. 38, 203-207.
7. [7] Dougherty, T.J. (1985) Photodynamic therapy. In: Methods in Porphyrin Photosensitization, pp. 313-323. Editor: D. Kessel. Plenum Press, New York.
8. [8] Sersa, G., Cemazar, M., Miklavcic, D. and Mir, L.M. (1994) Electrochemotherapy: variable antitumor effect on different tumor models. Bioelectrochem. Bioenerg., 35, 23-27.
9. [9] Salford, L.G., Persson, B.R.R., Brun, A., Ceberg, C.P. and Kongstad, P.C. (1993) A new brain tumor therapy combining bleomycin with in vivo electropermeabilization. Biochem. Biophys. Res. Commun., 194, 938-943.
10. [10] Tounekti, O., Pron, G., Belehradek, J. and Mir, L.M. (1993) Bleomycin, an apoptosis-mimetic drug that induces 2 types of cell death depending on the number of molecules internalized. Cancer Res., 53, 5462-5469.