GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 14, 1996, Pages 1715-1718

  Ye, Jianhua ^a   Doerrler, William T ^a   Lehrman, Mark A ^a   Falck, J R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANNOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL;

ANIMAL CELL; ARTICLE; CHIRALITY; CHO CELL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; MEMBRANE BINDING; NONHUMAN; PROTEIN BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ANIMALIA; RODENTIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0030598667     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00306-X     Document Type: Article

References (27)

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13. 11. Partial and total syntheses of GPI anchors: Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. J. Chem. Soc., Perkins Trans. 1995, 1673 and earlier references. Murakata, C.; Ogawa, T. Carbohydr. Res. 1992, 235, 95 and earlier references. Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. ibid. 1995, 270, 85. Verduyn, R.; Beliën, J. J. A.; Dreef-Tromp, C. M.; van der Mare, G. A.; van Boom, J. H. Tetrahedron Lett. 1991, 32, 6637. Plourde, R.; D'Alarcao, M. ibid. 1990, 31, 2693. Mootoo, D. R.; Konradsson, P.; Fraser-Reid, B. J. Am. Chem. Soc. 1989, 111, 8540.
14. 11. Partial and total syntheses of GPI anchors: Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. J. Chem. Soc., Perkins Trans. 1995, 1673 and earlier references. Murakata, C.; Ogawa, T. Carbohydr. Res. 1992, 235, 95 and earlier references. Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. ibid. 1995, 270, 85. Verduyn, R.; Beliën, J. J. A.; Dreef-Tromp, C. M.; van der Mare, G. A.; van Boom, J. H. Tetrahedron Lett. 1991, 32, 6637. Plourde, R.; D'Alarcao, M. ibid. 1990, 31, 2693. Mootoo, D. R.; Konradsson, P.; Fraser-Reid, B. J. Am. Chem. Soc. 1989, 111, 8540.
15. 11. Partial and total syntheses of GPI anchors: Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. J. Chem. Soc., Perkins Trans. 1995, 1673 and earlier references. Murakata, C.; Ogawa, T. Carbohydr. Res. 1992, 235, 95 and earlier references. Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. ibid. 1995, 270, 85. Verduyn, R.; Beliën, J. J. A.; Dreef-Tromp, C. M.; van der Mare, G. A.; van Boom, J. H. Tetrahedron Lett. 1991, 32, 6637. Plourde, R.; D'Alarcao, M. ibid. 1990, 31, 2693. Mootoo, D. R.; Konradsson, P.; Fraser-Reid, B. J. Am. Chem. Soc. 1989, 111, 8540.
16. 11. Partial and total syntheses of GPI anchors: Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. J. Chem. Soc., Perkins Trans. 1995, 1673 and earlier references. Murakata, C.; Ogawa, T. Carbohydr. Res. 1992, 235, 95 and earlier references. Cottaz, S.; Brimacombe, J. S.; Ferguson, M. A. J. ibid. 1995, 270, 85. Verduyn, R.; Beliën, J. J. A.; Dreef-Tromp, C. M.; van der Mare, G. A.; van Boom, J. H. Tetrahedron Lett. 1991, 32, 6637. Plourde, R.; D'Alarcao, M. ibid. 1990, 31, 2693. Mootoo, D. R.; Konradsson, P.; Fraser-Reid, B. J. Am. Chem. Soc. 1989, 111, 8540.
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20. 14. Satisfactory spectroscopic data were obtained for all new compounds using chromatographically homogeneous samples.
21. 3) δ 14.01, 22.54, 23.45, 23.62, 23.75, 23.86, 24.76, 24.83, 24.88, 24.99, 28.86, 28.97, 29.01, 31.59, 33.92, 34.01, 34.23, 61.44, 61.52, 61.99, 63.02, 65.65, 68.12, 69.20, 69.30, 69.56, 69.64, 69.77, 70.89, 72.04, 73.42, 74.93, 75.30, 76.14, 76.25, 76.78, 78.12, 80.01, 80.09, 96.82, 112.25, 113.27, 127.61, 127.73, 127.78, 127.90, 128.05, 128.30, 128.37, 128.63, 128.68, 135.21, 137.90, 137.94, 138.02, 172.68, 172.76.
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26. 20. Doerrler, W. T.; Ye, J.; Falck, J. R.; Lehrman, M. A., submitted for publication.
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