Motor effects of lamotrigine in naive and dopamine-depleted mice

European Journal of Pharmacology

Volumn 304, Issue 1-3, 1996, Pages 1-6

  Kaur, Simranjit ^a   Starr, Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

dopamine; lamotrigine; locomotion; mouse; reserpine

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ANTIPARKINSON AGENT; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR; LAMOTRIGINE; LEVODOPA; N (3 HYDROXYPHENETHYL) N (PHENETHYL)PROPYLAMINE; RESERPINE;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY POSTURE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG MECHANISM; DRUG POTENTIATION; GAIT; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MONOAMINE METABOLISM; MOTOR ACTIVITY; MOUSE; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030598616     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00134-3     Document Type: Article

References (24)

1. Albin, R.L., A.B. Young and J.B. Penney, 1989. The functional anatomy of basal ganglia disorders. Trends Neurosci. 12, 366.
2. Bergman, H., T. Wichmann and M.R. DeLong, 1990, Reversal of experimental parkinsonism by lesions of the subthalamic nucleus, Science 249, 1436.
3. Biggs, C.S., L.J. Fowler, P.S. Whitton and M.S. Starr, 1996, N-Methyl-D-aspartate receptor antagonists increase the release of dopamine newly synthesised from L-3,4-dihydroxyphenylalanine in the substantia nigra of reserpine-treated rats, Eur. J. Pharmacol. 299, 83.
4. Brotchie, J.M., I.J. Mitchell, M.A. Sambrook and A.R. Crossman, 1991. Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate, Mov. Disord. 6, 133.
5. Carter, A., 1994, Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination, J. Pharmacol. Exp. Ther. 269, 573.
6. Engber, T.M., S.M. Papa, R.C. Boldry and T.N. Chase, 1994, Reversal by NMDA receptor blockade of the motor response alterations induced by chronic levodopa, Neuroreport 5, 2586.
7. Ginski, M.J. and J.M. Witkin, 1994, Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists, Psychopharmacology 114, 573.
8. 2 agonists in the reserpine-treated mouse are affected differentially by the NMDA receptor antagonist MK 801, J. Neural Transm. [P.D. Sect.] 4, 15.
9. Hadjiconstantinou, M., Z.L. Rosetti, T.A. Wemlinger and N.H. Neff, 1995, Dizocilpine enhances striatal tyrosine hydroxylase and aromatic L-amino acid decarboxylase activity, Eur. J. Pharmacol. 289, 97.
10. Kamisaki, Y., T. Hamahashi, T. Hamada, K. Maeda and T. Itoh, 1992, Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions, Eur. J. Pharmacol. 217, 57.
11. 1 receptor mechanisms in the potentiation of motor responses to L-DOPA and apomorphine by MK 801 in the reserpine-treated mouse, J. Neural Transm. [P.D. Sect.] 7, 133.
12. Klockgether, T. and L. Turski, 1990, NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats, Adv. Neurol. 28, 539.
13. Löschmann, P.-A., F. Eblen, U. Wüllner, H. Wachtel and T. Klockgether, 1995, Lamotrigine has no antiparkinsonian activity in rat models of Parkinson's disease, Eur. J. Pharmacol. 284, 129.
14. Meldrum, B. and M. Leach, 1994, The mechanisms of action of lamotrigine, Rev. Contemp. Pharmacother. 5, 107.
15. Mitchell, I.J., N. Hughes, C.B. Carroll and J.M. Brotchie, 1995, Reversal of parkinsonian symptoms by intrastriatal and systemic manipulations of excitatory amino acid and dopamine transmission in the bilateral 6-OHDA lesioned marmoset, Behav. Pharmacol. 6, 492.
16. 2-mediated behaviour in the 6-hydroxydopamine model of turning: relationship with c-fos expression, J. Pharmacol. Exp. Ther. 290, 402.
17. Rubinstein, M., A.F. Schinder, O. Gershanik and F.J.E. Stefano, 1989, Positive interaction between alpha-1 adrenergic and dopamine-2 receptors in locomotor activity of normo and supersensitive mice, Life Sci. 44, 337.
18. 2 balance in the basal ganglia and its relevance to Parkinson's disease, Synapse 19, 264.
19. Starr, M.S., 1995b, Antiparkinsonian actions of glutamate antagonists - alone and with L-DOPA: a review of evidence and suggestions for possible mechanisms, J. Neural Transm. [P.D. Sect.] (in press).
20. 2 agonist apomorphine, J. Neural Transm. [P.D. Sect.] 6, 215.
21. 2 dopamine agonists in reserpine-treated mice, Psychopharmacology 114, 469.
22. 2 agonists, J. Neural Transm. [P.D. Sect.] 7, 133.
23. + channels in rat hippocampal neurones, Pflügers Arch. - Eur. J. Physiol. 430, 437.
24. Zipp, F., H. Baas and P.-A. Fischer, 1993, Lamotrigine-antiparkinsonian activity by blockade of glutamate release?, J. Neural Transm. [P.D. Sect.] 5, 67.