The thermolysis of benzyl cobaloximes: A new one step synthesis of 5-arylisoxazoles

Tetrahedron Letters

Volumn 37, Issue 30, 1996, Pages 5413-5416

  Brown, Trevor ^a   Dronsfield, Alan ^a   Jablonski, Anne ^b   Wilkinson, Alan Shaun ^a  

^a UNIVERSITY OF DERBY   (United Kingdom)

^b Ockbrook School   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISOXAZOLE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE; TEMPERATURE;

EID: 0030598072     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01059-3     Document Type: Article

References (6)

1. 1. Barber, G. N.; Olofson, R A. J. Org. Chem. 1978, 43, 3015.
2. 2. Schrauzer, G. N.; Windgassen, R. J. J. Am. Chem. Soc., 1967, 89, 1999.
3. 3. Brown, K. L.; Jang, G-W.; Segal, R.; Rajeshwar, K. Inorganica Chim. Acta, 1987, 128, 197.
4. 4. Brown, T. M.; Cooksey, C. J.; Crich, D; Dronsfield, A. T.; Ellis, R. J. Chem. Soc. Perkin Trans. 1, 1993, 2131.
5. 5. The benzyl cobaloximes 1a-j are known compounds and are easily prepared from the corresponding benzyl bromides in one-pot reactions: see Brown, T. M.; Cooksey, C. J. Educ. Chem., 1987, 24, 77 and references therein. For large-scale preparations of cobaloximes see Schrauzer, G. N. Inorg. Synth., 1968, 11, 61. The benzyl cobaloxime derived from 5 was prepared by Jeremy Stephens (University of Derby) who also (in part) investigated its conversion into isoxazoles 6, 7, and 8.
6. 5. The benzyl cobaloximes 1a-j are known compounds and are easily prepared from the corresponding benzyl bromides in one-pot reactions: see Brown, T. M.; Cooksey, C. J. Educ. Chem., 1987, 24, 77 and references therein. For large-scale preparations of cobaloximes see Schrauzer, G. N. Inorg. Synth., 1968, 11, 61. The benzyl cobaloxime derived from 5 was prepared by Jeremy Stephens (University of Derby) who also (in part) investigated its conversion into isoxazoles 6, 7, and 8.