Immunohistochemical localization of tissue factor pathway inhibitor-1 (TFPI-1), a Kunitz proteinase inhibitor, in Alzheimer's disease

Brain Research

Volumn 728, Issue 1, 1996, Pages 13-19

  Hollister, Richard D ^a   Kisiel, Walter ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Dementia; Lipoprotein associated coagulation inhibitor; Microglia; Neurodegeneration; Proteinase inhibitor; Senile plaque

Indexed keywords

AMYLOID BETA PROTEIN; APROTININ; PROTEINASE INHIBITOR;

ADULT; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROGLIA; NERVE DEGENERATION; PRIORITY JOURNAL; SENILE PLAQUE;

EID: 0030597989     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00384-8     Document Type: Article

References (50)

1. [1] Arai, H., Lee, V., Messinger, M., Greenberg, B., Lowery, D. and Trojanowski, J., Expression patterns of beta-amyloid precursor protein (beta-APP) in neural and nonneural human tissues from Alzheimer's disease and control subjects, Ann. Neurol., 30 (1991) 686-93.
2. [2] Banati, R., Gehrmann, J., Czech, C., Monning, U., Jones, L., Konig, G., Beyreuther. K. and Kreutzberg. G., Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia, GLIA, 9 (1993) 199-210.
3. [3] Broze, G.J., Warren, L., Novotny, W., Higuchi, D., Girard, J. and Miletich, J., The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood. 1 (1988) 335-343.
4. [4] Broze, G.J., The role of tissue factor pathway inhibitor in a revised coagulation cascade. Semin. Hematol., 29 (1992) 159-169.
5. [5] Broze, G.J., Wesselschmidt, R., Higuchi, D., Girard, T., Likert. K., MacPhail, L. and Wun, T.-C., The interaction between LACI and heparin, Adv. Exp. Med. Bio., 313 (1993) 189-197.
6. [6] Bush, A., Pettingell, W.J., de Paradis, M., Tanzi, R. and Wasco, W., The amyloid beta-protein precursor and its mammalian homologues. J. Biol. Chem., 269 (1994) 26618-26621.
7. [7] Enghild, J.. Thorgersen, I.. Pizzo, S. and Salvesen, G., In B. Festoff (Ed.). Serine proteases and serpins in the nerrous system. Plenum Press, New York. 1990. pp. 79-91.
8. [8] Enjyoji, K.. Miyata, T., Kamikubo, Y. and Kato, H., Effect of heparin on the inhibition of factor Xa by tissue factor pathway inhibitor: a segment, Gly212-Phe243, of the third Kunitz domain is a heparin binding site. Biochemistry, 34 (1995) 5725-5735.
9. [9] Enjyoji, K.-I., Emi, M., Mukai, T., Imada, M., Leppert, M.L., Lalouel, J.M. and Kato, H., Human tissue factor pathway inhibitor (TFPI) gene: Complete genomic structure and localization on the genetic map of chromosome 2q, Genomics, 17 (1993) 423-428.
10. [10] Gebhard, W., Hochstrasser, K., Fritz, H., Enghild, J., Pizzo, S. and Salvesen, G., Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology, Biol. Chem. Hoppe-Seyler, 371 (1990) 113-122.
11. [11] Girard, T.J. and Broze, G.J., Tissue factor pathway inhibitor, Methods Enzymol., 222 (1993) 195-209.
12. [12] Gollin, P., Kalaria, R., Eikelenboom, P., Rozemuller, A. and Perry, G., Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease. Neuroreport, 3 (1992) 201-203.
13. [13] Graebert, K., Lemansky, P., Kehle, T. and Herzog, V., Localization and regulated release of Alzheimer amyloid precursor-like protein in thyrocytes, Lab. Invest., 72 (1995) 513-523.
14. [14] Hamamoto, T., Yamamoto, M., Nordfang, O., Litske-Petersen, J., Foster, D. and Kisiel, W., Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI), J. Biol. Chem., 268 (1993) 8704-8710.
15. [15] Hansen, J.-B., Huseby, N.-E., Sandset, P.M., Svensson, B., Lyngmo, V. and Nordoy, A.. Tissue factor pathway inhibitor and lipoproteins: Evidence for association with and regulation by LDL in human plasma. Arterioscler. Thromb., 1994 (1994) 223-229.
16. [16] Hyman, B.T., Tanzi, R.E., Marzloff, K., Barbour, R. and Schenk, D., Kunitz protease inhibitor-containing amloid β-protein precursor immunoreactivity in Alzheimer's disease, J. Neuropathol. Exp. Neurol., 51 (1992) 76-83.
17. [17] Itagaki, S., McGeer, P., Akiyama, H., Zhu, S. and Selkoe, D., Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease, J. Neuroimmunol., 24 (1989) 173-182.
18. [18] Johnson, S., Pasinetti, G., May, P., Ponte, P., Cordell, B. and Finch, C., Selective reduction of mRNA for the beta-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer's brain, Exp. Neurol., 102 (1988) 264-268.
19. [19] Kalaria, R., Golde, T., Kroon, S. and Perry, G., Serine protease inhibitor antithrornbin III and its messenger RNA in the pathogenesis of Alzheimer's disease, Am. J. Pathol., 143 (1993) 886-893.
20. [20] Kang, J., Lemaire, H., Unterbeck, A., Salbaum, J., Masters, C., Grzeschik, K., Multhaup, G., Beyreuther, K. and Muller-Hill, B., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature, 325 (1987) 733-766.
21. [21] Kisiel, W., Sprecher, C. and Foster, D., Evidence that a second human tissue factor pathway inhibitor (TFPI-2) and human placental protein 5 are equivalent. Blood, 84 (1994) 4384-4385.
22. [22] Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S. and Ito, H., Novel precursor of Alzheimer's disease shows protease inhibitory activity. Nature, 331 (1988) 530-532.
23. [23] Koenig, G., Moenning, U., Czech, C., Prior, R., Banati, R., Schreiter-Gasser, U., Bauer, J., Masters, C. and Beyreuther, K., Identification and differential expression of a novel alternative splice isoform of the βA4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells, J. Biol. Chem., 267 (1992) 10804-10809.
24. [24] Kounnas, M., Moir, R., Rebeck, G.. Bush, A., Argraves, W., Tanzi, R., Hyman, B. and Strickland, D., LDL receptor-related protein, a multifunctional Apo E receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell, 82 (1995) 331-340.
25. [25] Lesnik, P., Vonica, A., Guerin, M., Moreau, M. and Chapman, M.J., Anticoagulant activity of tissue factor pathway inhibitor in human plasma Is preferentially associated with dense subspecies of LDL and HDL and with Lp(a). Arterioscler. Thromb., 13 (1993) 1066-1075.
26. [26] Nakajima, K., Shimojo, M., Hamanoue, M., Ishiura, S., Sugita, H. and Kohsaka, S., Identification of elastase as a secretory protease from cultured rat microglia, J. Neurochem., 58 (1992) 1401-1408.
27. [27] Nakajima, K., Tsuzaki, N.. Shimojo, M., Hamanoue, M. and Kohsaka, S., Microglia isolated from rat brain secrete a urokinase-type plasminogen, Brain Res., 577 (1992) 285-292.
28. [28] Neve, R., Finch, E. and Dawes, L., Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron. 1 (1988) 669-677.
29. [29] Novotny, W.F., Brown, S.G., Miletich, J.P., Rader, D.J. and Broze Jr., G.J., Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples. Blood, 78 (1991) 387-393.
30. [30] Novotny, W.F., Girard, T.J., Miletich, J.P. and Broze Jr., G.J., Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor. Blood. 72 (1988) 2020-2025.
31. [31] Novotny, W.F., Girard, T.J., Miletich, J.P. and Broze Jr., G.J., Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma. J. Biol. Chem., 264 (1989) 18832-18837.
32. [32] Novotny, W.F., Palmier, M.. Wun, T.-C., Broze Jr., G.J. and Miletich, J.P., Purification and properties of heparin-releasable lipoprotein-associated coagulation inhibitor, Blood. 78 (1991) 394-400.
33. [33] Palmert, M., Podlisny, M., Witker, D., Oltersdorf, T., Younkin, L., Selkoe, D. and Younkin, S., Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques, Biochem. Biophys. Res. Com., 156 (1988) 432-437.
34. [34] Palmier, M.O., Hall, L.J., Reisch. C.M., Baldwin, M.K., Wilson, A.G.E. and Wun, T.-C., Clearance of recombinant tissue factor pathway inhibitor (TFPI) in rabbits, Thromb. Haemost., 68 (1992) 33-36.
35. [35] Penfield. W., Microglia and the process of phagocytosis in gliomas, Am. J. Pathol., 1 (1925) 77-89.
36. [36] Pitas, R., Boyles, J., Lee, S., Hui, D. and Weisgraber, K., Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J. Biol. Chem., 262 (1987) 14352-14360.
37. [37] Ponte, P., Gonzalez-DeWhitt, P., Schilling, J., Miller, J., Hsu, D., Greenberg, B., Davis, K., Wallace, W., Lieberburg, I., Fuller, F. and Cordell, B., A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature. 331 (1988) 525-527.
38. [38] Rao, L. and Rapaport, S., Studies on the mechanism of inactivation of the extrinsic pathway of coagulation, Blood, 69 (1987) 645-651.
39. [39] Rebeck, G.W., Reiter, J., Strickland, D.K. and Hyman, B.T., Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions, Neuron, 11 (1993) 575-580.
40. 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann. Neurol., 37 (1995) 211-217.
41. [41] Sandbrink, R., Banati, R., Masters, C., Beyreuther, K. and Konig, G., Expression of L-APP mRNA in brain cells, Ann. NY Acad. Sci., 695 (1993) 183-189.
42. [42] Sprecher, C.A., Kisiel. W., Mathewes, S. and Foster, D.C., Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. Proc. Natl. Acad. Sci. USA, 91 (1994) 3353-3357.
43. [43] Tanaka, S., Satoshi, S., Takahashi, Y., Kitaguchi, N., Ito, H., Kameyama, M., Kimura, J., Nakamura, S. and Ueda, K., Tissue specific expression of three types of β protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain, Biochem. Biophys. Res. Commun., 165 (1989) 1406-1414.
44. [44] Tanzi, R.E., McClatchey, A.I., Lamperti, E.D., Villa-Komaroff, L., Gusella. J.F. and Neve, R.L., Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's Disease, Nature, 331 (1988) 528-532.
45. [45] Van Nostrand, W., Schmaier, A., Neiditch, B., Siegel, R., Raschke, W., Sisodia, S. and Wagner, S., Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2, Biochim. Biophys. Acta. 1209 (1994) 165-170.
46. [46] Warshawsky, I., Broze, G.J. and Schwartz, A.L., The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor, Proc. Natl. Acad. Sci. USA, 91 (1994) 6664-6668.
47. [47] Wasco, W., Bupp, K., Magendantz, M., Gusella, J., Tanzi, R. and Solomon, F., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor, Proc. Natl. Acad. Sci. USA, 89 (1992) 10758-10762.
48. [48] Wesselschmidt, R., MacPhail, L. and Broze, G.J., Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin, Blood, 80 (1992) 263a.
49. [49] Wisniewski, H. and Terry, R., Reexamination of the pathogenesis of the senile plaque. In H.M. Zimmermann (Ed.), Progress in Neuropathology, Grune and Stratton, New York, 1973, pp. 1-26.
50. [50] Wun, T., Kretzmer, K., Girard, T., Miletich, J. and Broze, G.J., Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. J. Biol. Chem., 263 (1988) 6001-6004.