A study of the structural basis of the ability of chlorinated alkanes and alkenes to induce aneuploidy and toxicity in the mold Aspergillus nidulans

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 354, Issue 2, 1996, Pages 183-193

  Rosenkranz, Herbert S ^a   Klopman, Gilles ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Alkane; Aneuploidy; Aspergillus nidulans; Clorinated alkane; Toxicity

Indexed keywords

ALKANE DERIVATIVE; ALKENE DERIVATIVE; CHLORINATED HYDROCARBON;

ANEUPLOIDY; ARTICLE; ASPERGILLUS NIDULANS; COMPUTER SYSTEM; GENOTOXICITY; GROWTH INHIBITION; MUTAGENICITY; MUTATION; NONHUMAN; PRIORITY JOURNAL;

ASPERGILLUS; EMERICELLA NIDULANS; SALMONELLA;

EID: 0030597966     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00015-2     Document Type: Article

References (30)

1. Ashby, J. (1992) Use of short-term tests in determining the genotoxicity or non-genotoxicity of chemicals. In: Vainio, Magee, McGregor and McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification, No. 116. International Agency for Research on Cancer. Lyon. pp. 135-164.
2. Ashby, J. (1994) Two million rodent carcinogens? The role of SAR and QSAR in their detection. Mutation Res., 305, 3-12.
3. Ashby, J. and R.W. Tennant (1988) Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutation Res., 204, 17-115.
4. Ashby, J., R.W. Tennant, E. Zeiger and S. Stasiewicz (1989) Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. Mutation Res., 223, 73-103.
5. Crebelli, R., C. Andreoli, A. Carere, G. Conti, E. Conti, M. Conti Ramusino and R. Benigni (1992) The induction of mitotic chromosome malsegregation in Aspergillus nidulans. Quantitative structure-activity relationship (QSAR) analysis with chlorinated aliphatic hydrocarbons. Mutation Res., 226, 117-134.
6. Dellarco, V.L., K.H. Mavournin and R.R. Tice (1985) Aneuploidy and health risk assessment: Current status and future directions. Environ. Mutagen., 7, 405-424.
7. Dunkel, V., E. Zeiger, D. Brusick, E.C. McCoy, D. McGregor, K. Mortelmans, H.S. Rosenkranz and V.F. Simmon (1984) Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standard protocol. Environ. Mutagen., 6, Suppl. 2, 1-251.
8. Dunkel, V.C., E. Zeiger, D. Brusick, E. McCoy, D. McGregor, K. Mortelmans, H.S. Rosenkranz and V.F. Simmon (1985) Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli. Environ. Mutagen. 7, Suppl. 5, 1-248.
9. Houser, J.J. and G. Klopman (1988) A new tool for the rapid estimation of charge distribution. J. Comput. Chem., 9, 893-904.
10. Houser, J.J. and G. Klopman (1992) The rapid estimation of charge distribution. II. Heteroatoms. J. Comput. Chem., 13, 990-996.
11. IARC (1992) Mechanisms of Carcinogenesis in Risk Identification (H. Vainio, P. Magee, D. McGregor and A.J. McMichael, Eds.) IARC Scientific Publication No. 116, International Agency for Research on Cancer, Lyon, France.
12. Klopman, G. (1964) A semiempirical treatment of molecular structures. I. Electronegativity and atomic terms. J. Am. Chem. Soc. 86, 1463-1469.
13. Klopman, G. (1992) MULTICASE 1. A hierarchical Computer Automated Structure Evaluation program. Quant. Struct. Activity Relationships, 11, 176-184.
14. Klopman, G. and H.S. Rosenkranz (1991a) Quantification of the predictivity of some short term assays for carcinogenicity in rodents. Mutation Res. 253, 237-240.
15. Klopman, G. and H.S. Rosenkranz (1991b) Structure-activity relations: Maximizing the usefulness of mutagenicity and carcinogenicity data bases. Environ. Health Perspect., 96, 67-75.
16. Klopman, G. and H.S. Rosenkranz (1994) Prediction of carcinogenicity/mutagenicity using MULTICASE. Mutation Res., 305, 33-46.
17. Klopman, G. and S. Wang (1991) A Computer Automated Structure Evaluation (CASE) approach to calculation of partition coefficient. J. Comput. Chem., 12, 1025-1032.
18. Klopman, G., S. Wang and D.M. Balthasar (1992) Estimation of aqueous solubility of organic molecules by the group contribution approach. Application to the study of biodegradation. J. Chem. Inf. Comp. Sci., 32, 474-482.
19. Miller, J.A. and E.G. Miller (1977) Ultimate chemical carcinogens as reactive mutagenic eletrophiles. In: H.H. Hiatt, J.D. Watson and J.A. Winsten (Eds.), Origins of Human Cancer. Cold Spring Harbor Laboratory: Cold Spring Harbor, pp. 605-627.
20. Mortelmans, K., S. Haworth, T. Lawlor, W.T. Speck, B. Tainer and E. Zeiger (1986) Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals. Environ. Mutagen, 8, 1-119.
21. Pearson, R.G. (1986) Absolute electronegativity and hardness correlated with molecular orbital theory. Proc. Natl. Acad. Sci. USA, 83, 8440-8441.
22. Rosenkranz, H.S. (1992) Structure-activity relationships for carcinogens with differing modes of action. In: Vainio, Magee, McGregor and McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification. No. 116 International Agency for Research on Cancer, Lyon. pp. 271-277.
23. Rosenkranz, H.S. and G. Klopman (1990) The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: The National Toxicology Program data base. Mutation Res., 228, 51-80.
24. Rosenkranz, H.S. and G. Klopman (1991) An expert system approach to the prediction and elucidation of the structural basis of toxicological activities. In: (A.M. Goldberg (Ed.), Alternative Methods in Toxicology. Vol. 8. In Vitro Toxicology: New Technology. Mary Ann Liebert, Inc., New York, pp. 145-162.
25. Rosenkranz, H.S. and G. Klopman (1995) Relationships between electronegativity and genotoxicity. Mutation Res., 328, 215-227.
26. Takihi, N., Y.P. Zhang, G. Klopman and H.S. Rosenkranz (1993) An approach for evaluating and increasing the informational content of mutagenicity and clastogenidty data bases. Mutagenesis, 8, 257-264.
27. Tennant, R.W. and J. Ashby (1991) Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. Mutation Res., 257, 209-227.
28. Zeiger, E. (1987) Carcinogenicity of mutagens: Predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity. Cancer Res., 47, 1287-1296.
29. Zeiger, E., B. Anderson, S. Haworth, T. Lawlor, K. Mortelmans and W. Speck (1987) Salmonella mutagenicity tests: III. Results from 255 chemicals. Environ. Mutagen., 9, Suppl. 9: 1-109.
30. Zeiger, E., B. Anderson, S. Haworth, T. Lawlor and K. Mortelmans (1988) Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen., 11, Suppl. 12, 1-157.