Transcription of the human hepatic lipase gene is modulated by multiple negative elements in HepG2 cells

Gene

Volumn 180, Issue 1-2, 1996, Pages 69-80

  Oka, Kazuhiro ^a   Ishimura Oka, Kazumi ^a   Chu, Mei Jin ^a   Chan, Lawrence ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

DNase I protection assay; HeLa; Mutagenesis; Promoter activity; Regulatory element

Indexed keywords

CIS ACTING ELEMENT; DEOXYRIBONUCLEASE I; LIVER TRIACYLGLYCEROL LIPASE; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DELETION MUTANT; DNA FLANKING REGION; DNA FOOTPRINTING; DNA TRANSCRIPTION; DNA TRANSFECTION; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE FUSION; GENE MUTATION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT;

BASE SEQUENCE; CELL EXTRACTS; CELL LINE; CELL NUCLEUS; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMAN GROWTH HORMONE; HUMANS; LIPASE; LIVER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0030597339     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(96)00408-8     Document Type: Article

References (61)

1. Ameis, D., Stahnke, G., Kobayashi, J., McLean, J., Lee, G., Büscher, M., Schotz, M. and Will, H. (1990) Isolation and characterization of the human hepatic lipase gene. J. Biol. Chem. 265, 6552-6555.
2. 2 cholesterol. Arteriosclerosis 5, 273-282.
3. Bamberger, M., Glick, J.M. and Rothblat, G.H. (1983) Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells. J. Lipid Res. 24, 869-876.
4. Bamberger, M., Lund-Katz, S., Phillips, M.C. and Rothblat, G.H. (1985) Mechanism of the hepatic lipase induced accumulation of high-density lipoprotein cholesterol by cells in culture. Biochemistry 24, 3693-3701.
5. Baniahmad, A., Muller, M., Steiner, C. and Renkauits, R. (1987) Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements. EMBO J. 6, 2297-2303.
6. Boyle, W.J., Smeal, T, Defize, L.H.K., Angel. P., Woodgett, J.R., Karin, M. and Hunter, T. (1991) Activation of protein kinase C decreases phosphorylation of C-Jun at sites that negatively regulate its DNA-binding activity. Cell 64, 573-584.
7. Breckenridge, W.C., Little, J.A., Alaupovic, P., Wang, C.S., Kuksis, A., Kakis, G., Lindgren, F. and Gardiner, G. (1982) Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase. Atherosclerosis 45, 161-179.
8. Busch, S.J., Martin, G.A., Barnhart, R.L. and Jackson, R.L. (1989) Heparin induces the expression of hepatic triglyceride lipase in a human hepatoma (HepG2) cell line. J. Biol. Chem. 264, 9527-9532.
9. Busch, S.J., Barnhart, R.L., Martin, G.A., Flanagan, M.A. and Jackson, R.L. (1990) Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CA reductase gene expression in a human hepatoma cell line, HepG2. J. Biol. Chem. 265, 22474-22479.
10. Busch, S.J., Barnhart, R.L., Martin, G.A., Fitzgerald, M.C., Yates, M.T., Mao, S.J., Thomas, C.E. and Jackson, R.J. (1994) Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice. J. Biol. Chem. 269, 16376-16382.
11. Cai, S.-J., Wong, D.M., Chen, S.-H. and Chan, L. (1989) Structure of the human hepatic triglyceride lipase gene. Biochemistry 28, 8966-8971.
12. Carlson, L.A., Holmquist, L. and Nilsson-Ehle, P. (1986) Deficiency of hepatic-lipase activity in post-heparin plasma in familial hyper-beta-triglyceridemia. Acta Med. Scand. 219, 435-447.
13. Dang, Q., Walker, D., Taylor, S., Allan, C., Chin, P., Fan, J. and Taylor, J. (1995) Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus. J. Biol. Chem. 270, 22577-22585.
14. Datta, S., Luo, C.-C. Li, W.-H., VanTuinen, P., Ledbetter, D.H., Brown, M.A., Chen, S.-H., Liu, S.-W. and Chan, L. (1988) Human hepatic lipase, cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipasc. J. Biol. Chem. 263, 1107-1110.
15. Dignam, J.D., Lebovitz, R.M. and Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
16. Doolittle, M.H., Wong, H., Davis, R.L. and Schotz, M.C. (1987) Synthesis of hepatic lipase in liver and extrahepatic tissues. J. Lipid Res. 28, 1326-1334.
17. Faisst, S. and Meyer, S. (1992) Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res. 20, 3-26.
18. Fan, J., Wang, J., Bensadoun, A., Lauer, S.J., Dang, Q., Mahley, R.W. and Taylor, J.M. (1994) Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc. Natl. Acad. Sci. USA 91, 8724-8728.
19. Frain, M., Swart, G., Monaci, P., Nicosia, A., Stämpfli, S., Frank, R. and Cortese, R. (1989) The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 59, 145-157.
20. Godbout, R., Ingram, R.S. and Tilghman, S.M. ( 1986) Multiple regulatory elements in the intergenic region between the α-fetoprotein and albumin genes. Mol. Cell. Biol. 6, 477-487.
21. Gorski, K., Carneiro, M. and Schibler, U. (1986) Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47, 767-776.
22. Grange, T., Roux, J., Rigaud, G. and Pictet, R. (1991) Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine amino-transferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res. 19, 131-139.
23. Hadzopoulou-Cladaras, M. and Cardot P. (1993) Identification of a cis-acting negative DNA element which modulates human hepatic triglyceride lipase gene expression. Biochemistry 32, 9657-9667.
24. Hadzopoulou-Cladaras, M., Cardot, P., Zannis, V.I. and Cladaras, C. (1991) Transcriptional regulation of the human hepatic lipase gene. Circulation 84, 258A.
25. Hide, W.A., Chan, L. and Li, W.-H. (1992) Structure and evolution of the lipase superfamily. J. Lipid Res. 33, 167-178.
26. Hixenbaugh, E.A., Sullivan, T.R., Jr., Strauss, J.F., III, Laposata, E.A., Komaromy, M. and Paarola, L.G. (1989) Hepatic lipase in the rat ovary. Ovaries cannot synthesize hepatic lipase but accumulate it from the circulation. J. Biol. Chem. 264, 4222-4230.
27. Honanics, G.E., de Silva, H.V., Osada, J., Zhang, S.H., Wong, H., Borensztajn, J. and Maeda, N. (1995) Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J. Biol. Chem. 270, 2974-2980.
28. Huttunen, J.K., Ehnholm, C., Kekki, M. and Nikkilä, E.A. (1976) Postheparin plasma lipoprotein lipase and hepatic lipase in normal subjects and in patients with hypertriglyceridemia: correlations to sex, age and various parameters of triglyceride metabolism. Clin. Sci. Mol. Med. 50, 249-260.
29. Jackson, R.L. (1983) Lipoprotein lipase and hepatic lipase. In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., Vol. 16. Academic Press, New York, pp. 141-181.
30. Jansen, H., Kalkman, C., Birkenhäger, J.C. and Hülsmann, W.C. (1980a) Demonstration of a heparin-releasable liver-lipase-like activity in rat adrenals. FEBS Lett. 112, 30-34.
31. Jansen, H., van Tol. A. and Hülsmann, W.C. (1980b) On the metabolic function of heparin releasable liver lipase. Biochem. Biophys. Res. Commun. 92, 53-59.
32. Ji, Z.-S., Lauer, S.J., Fazio, S., Bensadoun, A., Taylor, J.M. and Mahley, R.W. (1994) Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. J. Biol. Chem. 269, 13429-13436.
33. Johnson, P.F., Landschulz, W.H., Graves, B.J. and McKnight, S.L. (1987) Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev. 1, 133-146.
34. Kageyama, R. and Pastan. I. (1989) Molecular cloning and characterization of a human DNA binding factor that represses transcription. Cell 59, 815-825.
35. Kinnunen, P.K.J. (1984) Hepatic endothelial lipase: isolation, some characteristics, and physiological role. In: Borgstrom, B. and Brockman, H.L. (Eds.), Lipases. Elsevier Scientific Publ., New York, pp. 307-328.
36. Kirschgessner, T.G., Chuat, J.C., Heinzman, C., Etienne, J., Guilhot, S., Svenson, K., Ameis, D., Pilon, C., D'Auriol, L., Anadalibi, A., Schotz, M.I., Galibert, F. and Lusis, A.J. (1989) Organization of the human lipoprotein lipase gene and evolution of the lipase family. Proc. Natl. Acad. Sci. USA 86, 9647-9651.
37. Komaromy, M.C. and Schotz, M.C. (1987) Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family. Proc. Natl. Acad. Sci. USA 84, 1526-1530.
38. Kuusi, T., Nikkilä, E.A., Taskinen, M.-R., Somerharju, P. and Ehnholm, C. (1982) Human postheparin plasma hepatic lipase activity against triacylglycerol and phospholipid substrates. Clin. Chim. Acta 122, 39-45.
39. Kuusi, T., Kesaniemi, A., Vuoristo, M., Miettinen, T.A. and Koskenvuo, M. (1987) Inheritance of high density lipoprotein and lipoprotein lipase and hepatic lipase activities. Arteriosclerosis 7, 421-425.
40. Ladias, P., Hadzopoulou-Cladaras, M., Kardasis, D., Cardot, P., Cheng, J., Zannis, V. and Cladaras, C. (1992) Transcriptional regulation of human apolipoprotein genes apoB, apoCHI, and apoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2 and EAR-3. J. Biol. Chem. 267, 15849-15860.
41. Lee, W., Mitchell, P. and Tjian, R. (1987) Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49, 741-752.
42. Little, J.A. and Connelly, P.W. (1986) Familial hepatic lipase deficiency. Adv. Exp. Med. Biol. 201, 253-260.
43. MacGregor, G.R., Moss, A.E., Burke, J.F. and Caskey, C.T. (1987) Histochemical staining of clonal mammalian cell lines expressing E. coli β-galactosidase indicates heterogenous expression of the bacterial gene. Somat. Cell Mol. Genet. 13, 253-265.
44. Maxam, A.M. and Gilbert, W. (1977) A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74, 560-564.
45. Mietus-Snyder, M., Sladek, F.M., Ginsburg, G.S., Kuo, C.F., Ladias, J.A.A., Darnell, J.E., Jr. and Karathanasis, S.K. (1992) Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIV gene expression in liver and intestinal cells. Mol. Cell. Biol. 12, 1708-1718.
46. 1-antitrypsin promoter. EMBO J. 7, 2075-2087.
47. Nozaki, S., Kubo, M., Sudo, H., Matsuzawa, Y. and Tarui, S. (1986) The role of hepatic triglyceride lipase in the metabolism of intermediate-density lipoprotein-postheparin lypolytic activities determined by a sensitive nonradioisotopic method in hyperlipidemic patients and normals. Metabolism 35, 53-58.
48. Paulweber, B., Onasch, M.A., Nagy, B.P. and Levy-Wilson, B. (1991) Similarities and differences on the function of regulatory elements at the 5′ end of the human apolipoprotein B gene in cultured hepatoma (HepG2) and colon carcinoma (CaCo-2) cells. J. Biol. Chem. 266, 24149-24160.
49. Rao, S.N., Cortese, C., Miller, N.E., Levy, Y. and Lewis, B. (1982) Effects of heparin infusion on plasma lipoproteins in subjects with lipoprotein lipase deficiency. Evidence for a role of hepatic endothelial lipase in the metabolism of high-density lipoprotein subfractions in man. FEBS Lett. 150, 255-259.
50. Savagner, P., Miyashita, T. and Yamada Y. (1990) Two silencers regulate the tissue-specific expression of the collagen II gene. J. Biol. Chem. 265, 6669-6674.
51. Seiden, R.F., Howie, K.B., Rowe, M.E., Goodman, H.M. and Moore, D.D. (1986) Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol. Cell. Biol. 6, 3173-3179.
52. Semenkovich, C.F., Chen, S.-H., Wims, M., Luo, C.-C., Li, W.-H. and Chan, L. (1989) Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation and evolution. J. Lipid Res. 30, 423-431.
53. Shachter, N.S., Zhu, Y., Walsh, A., Breslow, J.-L. and Smith, J.D. (1993) Localization of a liver-specific enhancer in the apolipoprotein E/CI/C-II gene locus. J. Lipid Res. 34, 1699-1707.
54. Simonet, W.S., Bucay, N.B., Lauer, S.J. and Taylor, J.M. (1993) A fardownstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. J. Biol. Chem. 268, 8221-8229.
55. Smith, J.D., Melián, A., Leff, T. and Breslow, J.L. (1988) Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements. J. Biol. Chem. 263, 8300-8308.
56. Sparkes, R.S., Zollman, S., Klisak, I., Kirschgessner, T.G., Komaromy, M.C., Mohandas, T., Schotz, M.C. and Lusis, A.J. (1987) Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21. Genomics 1, 138-144.
57. Staels, B., Jansen, H., van Tol, A., Stahnke, G., Will, H., Verhoeven, G. and Auwerx, J. (1990a) Development, food intake, and ethinylestradiol influence hepatic triglyceride lipase and LPL-receptor mRNA levels in rats. J. Lipid Res. 31, 1211-1218.
58. Staels, B., van Tol, A., Chan, L., Will, H., Verhoeven, G, and Auwerx, J. (1990b) Alterations in thyroid status modulate apolipoprotein hepatic triglyceride lipase, and low density lipoprotein receptor in rats. Endocrinology 127, 1144-1152.
59. Widom, R.L., Ladias, J.A.A., Kouidou, S. and Karathanasis, S.K. (1991) Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells. Mol. Cell Biol. 11, 677-687.
60. Williams, T. and Tjian, R. (1991) Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 5, 670-682.
61. Williams, T., Admon, A., Lüscher, B. and Tjian, R. (1988) Cloning and expression of AP-2, a cell-type specific transcription factor that activates inducible enhancer elements. Genes Dev. 12, 1557-1569.