Parallel synthesis using Mannich-type three-component reactions and 'field synthesis' for the construction of an amino alcohol library

Tetrahedron Letters

Volumn 37, Issue 43, 1996, Pages 7783-7786

  Kobayashi, Shu ^a   Moriwaki, Mitsuhiro ^a   Akiyama, Ryo ^a   Suzuki, Shu ^a   Hachiya, Iwao ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOALCOHOL;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0030597207     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01777-7     Document Type: Article

References (23)

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10. (3) (a) Kobayashi, S.; Araki, M.; Yasuda, M. Tetrahedron Lett. 1995, 36, 5773-5776.
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12. (4) (a) Ugi, I.; Dömling, A.; Hörl, W. Endeavour 1994, 18, 115-122.
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17. (6) Cf. (a) Merrill, A. H., Jr.; Jones, D. D. Biochim. Biophys. Acta 1990, 1044, 1.
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19. (7) The three-component reactions are successfully carried out in liquid phase. See Ref. 3a.
20. (8) Kobayashi, S.; Hachiya, I.; Suzuki, S.; Moriwaki, M. Tetrahedron Lett. 1996, 37, 2809-2812.
21. (9) The yield was based on the polymer-supported silyl enol ether (PSSEE).
22. (10) The yields will be improved by using excess aldehydes and imines. For example, when two equivalents of the aldehyde and the amine were used, the yield in the combination of PSSEE 2 and amine I in Field 4 was improved to 72%.
23. (11) β-Amino Acid and β-lactam libraries are also constructed according to the present method. (equation presented)