Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans

Chemico-Biological Interactions

Volumn 102, Issue 2, 1996, Pages 79-92

  Zhang, Donglu ^a   Evans, Frederick E ^a   Freeman, James P ^a   Yang, Yifan ^a   Deck, Joanna ^a   Cerniglia, Carl E ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Cunninghamella elegans; Cyclobenzaprine; Cytochrome P 450; Drug metabolism; Hydroxylation; Microbial biotransformation; N Demethylation; N Oxidation

Indexed keywords

CYCLOBENZAPRINE; CYTOCHROME P450; DRUG METABOLITE; NORCYCLOBENZAPRINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG METABOLISM; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; ULTRAVIOLET SPECTROSCOPY;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; OXYGEN; OXYGEN ISOTOPES; RATS;

ANIMALIA; CUNNINGHAMELLA ELEGANS; FUNGI; MAMMALIA;

EID: 0030597154     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(96)03736-2     Document Type: Article

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