Vitamin D3 reduces the apoptotic effect of IFN-γ but does not facilitate HLA class II inducibility in RB-defective cells

Cancer Letters

Volumn 110, Issue 1-2, 1996, Pages 169-176

  Schmidt, Brian ^b   Carter, Stacy S ^b   Berry, Donna E ^b   Blanck, George ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b MDC 7 ^*

Author keywords

IFN ; Retinoblastoma protein; Vitamin D3

Indexed keywords

COLECALCIFEROL; GAMMA INTERFERON; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE INDUCTION; HISTOCOMPATIBILITY GENE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

APOPTOSIS; CELL CYCLE; CHOLECALCIFEROL; DNA; DNA FRAGMENTATION; GENES, MHC CLASS II; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERFERON TYPE II; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 0030596123     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04487-4     Document Type: Article

References (38)

1. [1] Cresswell, P. (1994) Assembly, transport, and function of MHC class II molecules [Review], Annu. Rev. Immunol., 12, 259-293.
2. [2] Kappes, D. and Strominger, J.L. (1988) Human class II major histocompatibility complex genes and proteins [Review], Annu. Rev. Biochem., 57, 991-1028.
3. [3] Blanck, G., Lok, M., Kok, K., Downie, E., Korn, J.H. and Strominger, J.L. (1990) Gamma-interferon induction of HLA class II mRNAs in dermal fibroblasts studied by RNase protection analysis, Hum. Immunol., 29, 150-156.
4. [4] Collins, T., Korman, A.J., Wake, C.T., Boss, J.M., Kappes, D.J., Fiers, W., Ault, K.A., Gimbrone Jr, M.A., Strominger, J.L. and Pober, J.S. (1984) Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts, Proc. Natl. Acad. Sci. USA, 81, 4917-4921.
5. [5] Benacerraf, B. (1981) Role of MHC gene products in immune regulation [Review], Science, 212, 1229-1238.
6. [6] Ostrand-Rosenberg, S., Thakur, A. and Clements, V. (1990) Rejection of mouse sarcoma cells after transfection of MHC class II genes, J. Immunol., 144, 4068-4071.
7. [7] Baskar, S., Azarenko, V., Garcia Marshall, E., Hughes, E. and Ostrand-Rosenberg, S. (1994) MHC class II-transfected tumor cells induce long-term tumor-specific immunity in autologous mice, Cell. Immunol., 155, 123-133.
8. [8] Ostrand-Rosenberg, S. (1994) Tumor immunotherapy: the tumor cell as an antigen-presenting cell [Review], Curr. Opin. Immunol., 6, 722-727.
9. [9] Baskar, S., Glimcher, L., Nabavi, N., Jones, R.T. and Ostrand-Rosenberg, S. (1995) Major histocompatibility complex class II + B7-1 + tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice, J. Exp. Med., 181, 619-629.
10. [10] Lu, Y., Ussery, G.D., Muncaster, M.M., Gallie, B.L. and Blanck, G. (1994) Evidence for retinoblastoma protein (RB) dependent and independent IFN-gamma responses: RB acoordinately rescues IFN-gamma induction of MHC class II gene transcription in noninducible breast carcinoma cells, Oncogene, 9, 1015-1019.
11. [11] Lu, Y., Boss, J.M., Hu, S.-H., Xu, H.-J. and Blanck, G. (1996) Apoptosis independent retinoblastoma protein rescue of HLA class II mRNA IFN-gamma inducibility in non-small cell lung carcinoma: lack of surface HLA-DR expression associated with a specific defect in HLA-DRA induction, J. Immunol., 156, 2495-2502.
12. [12] Lu, Y., Tschickardt, M.E., Schmidt, B.J. and Blanck, G. (1996) A defect in IFN-gamma induction of CIITA, a common defect in human tumor lines, prevents retinoblastoma protein rescue of HLA class II inducibility and allows mapping of apoptosis to the non-CIITA branch of the IFN-gamma signal transduction pathway. Manuscript submitted.
13. [13] Kern, D.E., Klarnet, J.P., Jensen, M.C. and Greenberg, P.D. (1986) Requirement for recognition of class II molecules and processed tumor antigen for optimal generation of syngeneic tumor-specific class I-restricted CTL, J. Immunol., 136, 4303-4310.
14. [14] Topalian, S.L. (1994) MHC class II restricted tumor antigens and the role of CD4 + T cells in cancer immunotherapy [Review], Curr. Opin. Immunol., 6, 741-745.
15. [15] Helin, K. and Harlow, E. (1993) The retinoblastoma protein as a transcriptional represser, Trends Cell Biol., 3, 43-46.
16. [16] Ewen, M.E. (1994) The cell cycle and the retinoblastoma protein family [Review], Cancer Metastasis Rev., 13, 45-66.
17. [17] Weinberg, R.A. (1995) The retinoblastoma protein and cell cycle control [Review], Cell, 81, 323-330.
18. [18] Flemington, E.K., Speck, S.H. and Kaelin Jr, W.G. (1993) E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product, Proc. Natl. Acad. Sci. USA, 90, 6914-6918.
19. [19] Chen, P.L., Scully, P., Shew, J.Y., Wang, J.Y. and Lee, W.H. (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation, Cell, 58, 1193-1198.
20. [20] Mihara, K., Cao, X.R., Yen, A., Chandler, S., Driscoll, B., Murphree, A.L., T'Ang, A. and Fung, Y.K. (1989) Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product, Science, 246, 1300-1303.
21. [21] Thomas, N.S., Burke, L.C., Bybee, A. and Linch, D.C. (1991) The phosphorylation state of the retinoblastoma (RB) protein in G0/G1 is dependent on growth status, Oncogene, 6, 317-322.
22. [22] Lee, E.Y., Bookstein, R. and Lee, W.H. (1991) Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma [Review], Cancer Treat. Res., 53, 23-44.
23. [23] Takahashi, R., Hashimoto, T., Xu, H.J., Hu, S.X., Matsui, T., Miki, T., Bigo-Marshall, H., Aaronson, S.A. and Benedict, W.F. (1991) The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells, Proc. Natl. Acad. Sci. USA, 88, 5257-5261.
24. [24] Hamel, P.A., Phillips, R.A., Muncaster, M. and Gallie, B.L. (1993) Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression [Review], FASEB J., 7, 846-854.
25. [25] Knudson Jr, A.G. (1971) Mutation and cancer: statistical study of retinoblastoma, Proc. Natl. Acad. Sci. USA, 68, 820-823.
26. [26] Berry, D.E., Lu, Y., Schmidt, B., Fallon, P.G., O'Connell, C., Hu, S.-X., Xu, H.-J. and Blanck, G. (1996) Retinoblastoma protein inhibits interferon-gamma induced apoptosis, Oncogene, 12, 1809-1819.
27. [27] Lukas, J., Petersen, B.O., Holm, K., Bartek, J. and Helin, K. (1996) Deregulated expression of E2F family members induces S-phase entry and overcomes p16(INK4A)-mediated growth suppression, Mol. Cell. Biol., 16, 1047-1057.
28. [28] Shan, B. and Lee, W.H. (1994) Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis, Mol. Cell. Biol., 14, 8166-8173.
29. [29] Qin, X.Q., Livingston, D.M., Kaelin Jr, W.G. and Adams, P.D. (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis, Proc. Natl. Acad. Sci. USA, 91, 10918-10922.
30. [30] Steimle, V., Siegrist, C.A., Mottet, A., Lisowska-Grospierre, B. and Mach, B. (1994) Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA, Science, 265, 106-109.
31. [31] Lew, D.J., Decker, T., Strehlow, I. and Darnell, J.E. (1991) Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons, Mol. Cell. Biol., 11, 182-191.
32. [32] Amaldi, I., Reith, W., Berte, C. and Mach, B. (1989) Induction of HLA class II genes by IFN-gamma is transcriptional and requires a transacting protein, J. Immunol., 142, 999-1004.
33. [33] Vandewalle, B., Wattez, N. and Lefebvre, J. (1995) Effects of vitamin D3 derivatives on growth, differentiation and apoptosis in tumoral colonic HT 29 cells: possible implication of intracellular calcium, Cancer Lett., 97, 99-106.
34. [34] Muncaster, M.M., Cohen, B.L., Phillips, R.A. and Gallie, B.L. (1992) Failure of RB1 to reverse the malignant phenotype of human tumor cell lines, Cancer Res., 52, 654-661.
35. [35] Guy, K., van Heyningen, V., Cohen, B.B., Deane, D.L. and Steel, C.M. (1982) Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains, Eur. J. Immunol., 12, 942-948.
36. [36] Wyllie, A.H., Kerr, J.F. and Currie, A.R. (1980) Cell death: the significance of apoptosis [Review], Int. Rev. Cytol., 68, 251-306.
37. [37] Dive, C., Gregory, C.D., Phipps, D.J., Evans, D.L., Milner, A.E. and Wyllie, A.H. (1992) Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry, Biochim. Biophys. Acta, 1133, 275-285.
38. [38] Huschtscha, L.I., Jeitner, T.M., Andersson, C.E., Bartier, W.A. and Tattersall, M.H. (1994) Identification of apoptotic and necrotic human leukemic cells by flow cytometry, Exp. Cell Res., 212, 161-165.