Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-I(FIN) mutation (Leu 159→Arg) and low HDL cholesterol level without coronary artery disease

Atherosclerosis

Volumn 127, Issue 2, 1996, Pages 239-243

  Gylling, Helena ^a   Relas, Heikki ^a   Miettinen, Helena E ^a   Radhakrishnan, Rajaratnam ^a   Miettinen, Tatu A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

apolipoprotein A I mutation; apolipoprotein B 48; coronary artery disease; HDL cholesterol; postprandial lipoproteins; retinyl palmitate; squalene

Indexed keywords

APOLIPOPROTEIN B48; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; RETINOL PALMITATE; SQUALENE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; HETEROZYGOSITY; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; MUTATION; PRIORITY JOURNAL;

ADULT; ANTICARCINOGENIC AGENTS; APOLIPOPROTEIN A-I; APOLIPOPROTEIN B-48; APOLIPOPROTEINS B; CHOLESTEROL, HDL; CHOLESTEROL, VLDL; CHROMATOGRAPHY, GAS; CHYLOMICRONS; CORONARY DISEASE; DIETARY FATS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HETEROZYGOTE; HUMANS; MIDDLE AGED; POINT MUTATION; POSTPRANDIAL PERIOD; RISK FACTORS; SQUALENE; TRIGLYCERIDES; VITAMIN A;

EID: 0030596122     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(96)05961-8     Document Type: Article

References (18)

1. [1] Gordon DJ, Probstfield JL, Garrison RJ et al. High density lipoprotein cholesterol and cardiovascular disease: four prospective American studies. Circulation 1989;79:8-15.
2. [2] Groot PHE, van Stiphout WAHJ, Krauss XH et al. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arterioscler Thromb 1991;11:653-662.
3. [3] Patsch JR, Miesenböck G, Hopferwieser T et al. Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb 1992;12:1336-1345.
4. [4] Karpe F, Bard J-M, Steiner G, Carlson LA, Fruchart J-C, Hamsten A. HDLs and alimentary lipemia. Studies in men with previous myocardial infarction at a young age. Arterioscler Thromb 1993;13:11-22.
5. [5] Uiterwaal CSPM, Grobbee DE, Witteman JCM et al. Postprandial triglyceride response in young adult men and familial risk for coronary atherosclerosis. Ann Int Med 1994;121:576-583.
6. [6] Cohen JC, Grundy SM. Normal postprandial lipemia in men with low plasma HDL concentrations. Arterioscler Thromb 1992;12:972-975.
7. [7] Gylling H, Miettinen TA. Postabsorptive retinyl palmitate removal is retarded in lecithin-cholesterol acyltransferase deficiency. Eur J Clin Invest 1993;23:302-306.
8. [8] Ng DS, Vezina C, Wolever TS, Kuksis A, Hegele RA, Connelly PW. Apolipoprotein A-I deficiency. Biochemical and metabolic characteristics. Arterioscler Thromb Vasc Biol 1995;15:2157-2164.
9. FIN: dominantly inherited hypoalphalipoproteinemia due to a single base substitution in the apolipoprotein A-I gene. Arterioscler Thromb Vasc Biol 1996; in press.
10. [10] Gylling H, Miettinen TA. Postabsorptive metabolism of dietary squalene. Atherosclerosis 1994;106:169-178.
11. [11] Lipid Research Clinics Program. Lipid and Lipoprotein Analysis: Manual of Laboratory Operations. Washington, DC: DHEW publication No. NIH/75-628, US Government Printing Office; 1974.
12. [12] Havekes LM, de Knijff P, Beisiegel U, Havinga J, Smit M, Klasen E. A rapid micromethod for apolipoprotein E phenotyping directly in serum. J Lipid Res 1987;28:44-51.
13. [13] Karpe F, Hamsten A. Determination of apolipoproteins B-48 and B-100 in triglyceride-rich lipoproteins by analytical SDS-PAGE. J Lipid Res 1994;35:1311-1317.
14. [14] Miettinen TA. Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res 1988;29:43-51.
15. [15] King EJ, Wootton IDP. Microanalysis in medical biochemistry. London: J and A Churchill LTD, 1959;232.
16. [16] Karpe F, Bell M, Björkegren J, Hamsten A. Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100. Arterioscler Thromb Vasc Biol 1995;15:199-207.
17. [17] Cohn JS, Johnson EJ, Millar JS et al. Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J Lipid Res 1993;34:2033-2040.
18. [18] Weintraub MS, Eisenberg S, Breslow JL. Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and Type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil. J Clin Invest 1987;79:1110-1119.