Enhanced aggregation of β-amyloid-containing peptides by extracellular matrix and their degradation by the 68 kDa serine protease prepared from human brain

Neuroscience Letters

Volumn 220, Issue 3, 1996, Pages 159-162

  Matsumoto, Akira ^a   Enomoto, Taira ^a   Fujiwara, Yoshisada ^a   Baba, Hisamitsu ^a   Matsumoto, Reiko ^b  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Osaka Teishin Hospital   (Japan)

Author keywords

Amyloid; Aggregation; Collagen type IV; Extracellular matrix; Serine protease Alzheimer's disease

Indexed keywords

AMYLOID BETA PROTEIN; COLLAGEN TYPE 4; SERINE PROTEINASE;

AGED; ALZHEIMER DISEASE; ARTICLE; CASE REPORT; CELL AGGREGATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BLOTTING, WESTERN; BRAIN; EPITOPES; EXTRACELLULAR MATRIX; FEMALE; HEPARITIN SULFATE; HUMANS; MALE; MIDDLE AGED; PRECIPITIN TESTS; SERINE ENDOPEPTIDASES;

EID: 0030596048     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13235-3     Document Type: Article

References (20)

1. [1] Bronfman, F.C., Soto, C., Tapia, L., Tapia, V. and Inestrosa, N.C., Extracellular matrix regulates the amount of the β-amyloid precursor protein and its amyloidogenic fragments, J. Cell. Physiol., 166 (1996) 360-369.
2. [2] Buee, L., Ding, W., Anderson, J.P., Narindrasorasak, S., Kisilevsky, R., Boyle, N.J., Robakis, N.K., Delacourte, A., Greenberg, B. and Fillit, H.M., Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide, Brain Res., 627 (1993) 199-204.
3. [3] Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rosser, M., Roques, P., Hardy, J. and Mullan, M., Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene, Nature, 353 (1991) 844-846.
4. [4] Danielsson, A., Raub, E., Lindahl, U. and Björk, I., Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the asseleration of the reactions between antithrombin and thrombin or factor Xa, J. Biol. Chem., 261 (1986) 15467-15473.
5. [5] Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Kahn, K., Lee, M., Leibowitz, P., Lieberburg, L, Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penninlan, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B. and Zhao, J., Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein, Nature, 373 (1995) 593-597.
6. [6] Haass, C., Lemere, C.A., Capell, A., Citron, M., Seubert, P., Schenk, D., Lannfelt, L. and Selkoe, D.J., The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway, Nat. Med., 1 (1995) 1291-1296.
7. [7] Hynes, R.O. and Lander, A.D., Contact and adhesive specificities in the associations, migrations and targeting of cells and axons, Cell, 68 (1992) 302-322.
8. [8] Kjellen, L. and Lindahl, U., Proteoglycans: structures and interactions, Annu. Rev. Biochem., 60 (1991) 443-475.
9. [9] Koo, E.H., Park, L. and Selkoe, D.J., Amyloid β-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth, Proc. Natl. Acad. Sci. USA, 90 (1993) 4748-4752.
10. [10] Levy-Lehad, E., Wijsman, E.M. and Nemens, E., Anderson, L., Goddard, K.A.B., Weber, J.L., Bird, T.D. and Schellenberg, G.D., A familial Alzheimer's disease locus on chromosome 1, Science, 269 (1995) 970-973.
11. [11] Matsumoto, A. and Fujiwara, Y., Aberrant proteolysis of the β-amyloid precursor protein in familial Alzheimer's disease lympho-blastoid cells, Eur. J. Biochem., 217 (1993) 21-27.
12. 2+-dependent 68-kilodalton protease in familial Alzheimer's disease cells cleaves the N-terminus of β-amyloid, Biochemistry, 33 (1994) 3941-3948.
13. [13] Matsumoto, A. and Matsumoto, R., Familial Alzheimer's disease cells abnormally accumulate β-amyloid-harbouring peptides preferentially in cytosol but not in extracellular fluid, Eur. J. Biochem., 225 (1994) 1055-1062.
14. [14] Matsumoto, A., Matsumoto, R., Baba, H. and Fujiwara, Y., A serine protease in Alzheimer's disease cells cleaves a 16 K-peptide with flanking residues upstream to β-amyloid-N-terminus as natural substrate, Neurosci. Lett., 195 (1995) 171-174.
15. [15] Matsumoto, A., Matsumoto, R. and Fujiwara, Y., Molecular cloning of human cDNA with a sequence highly similar to that of the dihydrofolate reductase gene in brain libraries derived from Alzheimer's disease patients, Eur. J. Biochem., 230 (1995) 337-343.
16. [16] Matsumoto, A., Matsumoto, R., Enomoto, T. and Baba, H., Human brain β-secretase contains heparan sulfate glycoconjugates, Neurosci. Lett., 211 (1996) 105-108.
17. [17] Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.-F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Da Silva, H.A.R., Haines, J.L., Pericak-Vance, M.A., Tanzi, R.E., Roses, A.D., Fraser, P.E., Rommens, J.M. and St George-Hyslop, P.H., Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature, 375 (1995) 754-760.
18. [18] Snow, A.D., Kinsella, M.G., Parks, E., Sekiguchi, R.T., Miller, J.D., Kimata, K. and Wight, T.N., Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin and versican) to the beta-amyloid protein of Alzheimer's disease, Arch. Biochem. Biophys., 320 (1995) 84-95.
19. [19] Su, J.H., Cummings, B.J. and Cotman, C.W., Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience, 51 (1992) 801-813.
20. [20] Van Broeckhoven, C., Hann, J., Bakker, E., Hardy, J.A., Van Hul, W., Wehnert, A., Vecter-Van der Vis, M. and Roos, R.A.C., Amyloid β protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch), Science, 248 (1990) 1120-1122.