Relation of cord plasma concentrations of proinsulin, 32-33 split proinsulin, insulin and C-peptide to placental weight and the baby's size and proportions at birth

Early Human Development

Volumn 46, Issue 1-2, 1996, Pages 129-140

  Godfrey, K M ^a   Hales, C N ^b   Osmond, C ^a   Barker, D J P ^a   Taylor, K P ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

32 33 split proinsulin; Cord plasma insulin; Fetal growth; Metabolic programming; Placental growth

Indexed keywords

C PEPTIDE; INSULIN; PROINSULIN;

ARTICLE; FETUS GROWTH; HEAD CIRCUMFERENCE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RELEASE; ISCHEMIC HEART DISEASE; NEWBORN; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PLACENTA WEIGHT; PROTEIN BLOOD LEVEL; UMBILICAL CORD BLOOD;

EID: 0030595370     PISSN: 03783782     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-3782(96)01752-5     Document Type: Article

References (44)

1. [1] Barker, D.J.P., Osmond, C., Simmonds, S.J. and Wield, G.A. (1993): The relation of head size and thinness at birth to death from cardiovascular disease in adult life. Br. Med. J., 306, 422-426.
2. [2] Barker, D.J.P. (1995): Fetal origins of coronary heart disease. Br. Med. J., 311, 171-174.
3. [3] Barker, D.J.P., Hales, C.N., Fall, C.H.D., Osmond, C., Phipps, K. and Clark, P.M.S. (1993): Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia, 36, 62-67.
4. [4] Barker, D.J.P., Gluckman, P.D., Godfrey, K.M., Harding, J.E., Owens, J.A. and Robinson, J.S. (1993): Fetal nutrition and cardiovascular disease in adult life. Lancet, 341, 938-941.
5. [5] Barker, D.J.P., Martyn, C.N., Osmond, C., Hales, C.N. and Fall, C.H.D. (1993): Growth in utero and serum cholesterol concentrations in adult life. Br. Med. J., 307, 1524-1527.
6. [6] Barker, D.J.P. (1994): Mothers, Babies and Disease in Later Life. BMJ Books, London.
7. [7] Beattie, R.B. and Johnson, P. (1994): Practical assessment of neonatal nutrition status beyond birthweight: an imperative for the 1990s. Br. J. Obstet. Gynaecol., 101, 842-846.
8. [8] Botting, B. and Cooper, J. (1993): Analysing fertility and infant mortality by mother's social class as defined by occupation - Part II. Popul. Trends, 74, 27-33.
9. [9] Boyd, R.D.H., D'Souza, S.W. and Sibley, C.P. (1994): Placental transfer. In: Early Fetal Growth and Development, pp. 211-221. Editors: R.H.T. Ward, S.K. Smith and D. Donnai. Royal College of Obstetricians and Gynaecologists, London.
10. [10] Campbell, D., Hall, M.H., Barker, D.J.P., Cross, J., Shiell, A.W. and Godfrey, K.M. (1996): Diet in pregnancy and the offspring's blood pressure 40 years later. Br. J. Obstet. Gynaecol., 103, 273-280.
11. [11] Dornhorst, A., Nicholls, J.S.D., Ali, K., Andres, C., Adamson, D.L., Kelly, L.F. et al. (1994): Fetal proinsulin and birth weight. Diabetic Med., 11, 177-181.
12. [12] Dornhorst, A., Paterson, C.M., Nicholls, J.S.D., Wadsworth, J., Chui, D.C., Elkeles, R.S. et al. (1992): High prevalence of gestational diabetes in women from ethnic minority groups. Diabetic Med., 9, 820-825.
13. [13] Economides, D.L., Proudler, A. and Nicolaides, K.H. (1989): Plasma insulin in appropriate-and small-for-gestational-age fetuses. Am. J. Obstet. Gynecol., 160, 1091-1094.
14. [14] Fowden, A.L. (1992): The role of insulin in fetal growth. Early Hum. Dev., 29, 177-181.
15. [15] Fowden, A.L. (1989): The role of insulin in prenatal growth. J. Dev. Physiol., 12, 173-182.
16. [16] Fowden, A.L. (1993): Insulin deficiency: effects on fetal growth and development. J. Paediatr. Child Health, 29, 6-11.
17. [17] Glauber, H.S., Revers, R.R., Henry, R., Schmeiser, L., Wallace, P., Kolterman, O.G. et al. (1986): In vivo deactivation of proinsulin action on glucose disposal and hepatic glucose production in normal man. Diabetes, 35, 311-317.
18. [18] Godfrey, K., Robinson, S., Barker, D., Osmond, C. and Cox, V. (1996): Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. Br. Med. J., 312, 410-414.
19. [19] Hales, C.N., Barker, D.J.P., Clark, P.M.S., Cox, L.J., Fall, C., Osmond, C. and Winter, P.D. (1991): Fetal and infant growth and impaired glucose tolerance at age 64. Br. Med. J., 303, 1019-1022.
20. [20] Hales, C.N. and Barker, D.J.P. (1992): Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia, 35, 595-601.
21. [21] Hawdon, J.M., Hubbard, M., Hales, C.N. and Clark, P. (1995): The use of a specific immunoradiometric assay to determine preterm neonatal insulin-glucose relationships. Arch. Dis. Child., 75, F166-169.
22. [22] Howe, D.T., Wheeler, T. and Osmond, C. (1995): The influence of maternal haemoglobin and ferritin on mid-pregnancy placental volume. Br. J. Obstet. Gynaecol., 102, 213-219.
23. [23] Law, C.M., Gordon, G.S., Shiell, A.W., Barker, D.J.P. and Hales, C.N. (1995): Thinness at birth and glucose tolerance in seven-year-old children. Diabetic Med., 12, 24-29.
24. [24] Mahendran, D., Donnai, P., Glazier, J.D., D'Souza, S.W., Boyd, R.D.H. and Sibley, C.P. (1993): Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies. Pediatr. Res., 34, 661-665.
25. [25] McCance, D.R., Pettitt, D.J., Hanson, R.L., Jacobsson, L.T.H., Knowler, W.C. and Bennett, P.H. (1994): Birthweight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype. Br. Med. J., 308, 942-945.
26. [26] McKeigue, P.M., Leon, D.A., Berglund, L., Kohsen, R. and Lithell, H.O. (1994): Relationship of birthweight and ponderal index to non-insulin-dependent diabetes and insulin response to glucose challenge in men aged 50-60 years. Diabetic Med., 11 (Suppl. 2), S17.
27. [27] Milner, R.D.G. and Hales, C.N. (1965): Effect of intravenous glucose on concentration of insulin in maternal and umbilical-cord plasma. Br. Med. J., 1, 284-286.
28. [28] Montemagno, R. and Soothill, P.W. (1994): The biochemistry of small for gestational age fetuses. In: Early Fetal Growth and Development, pp. 391-405. Editors: R.H.T. Ward, S.K. Smith and D. Donnai. Royal College of Obstetricians and Gynaecologists, London.
29. [29] Office of Population Censuses and Surveys (1980): Classification of Occupations. HMSO, London.
30. [30] Oliver, M.H., Harding, J.E., Breier, B.H., Evans, P.C. and Gluckman, P.D. (1993): Glucose but not a mixed amino acid infusion regulates plasma insulin-like growth factor (IGF)-I concentrations in fetal sheep. Pediatr. Res., 34, 62-65.
31. [31] Osmond, C., Barker, D.J.P., Winter, P.D., Fall, C.H.D. and Simmonds, S.J. (1993): Early growth and cardiovascular disease in women. Br. Med. J., 307, 1519-1524.
32. [32] Peavey, D.C., Brunner, M.R., Duckworth, W.C., Hooker, C.S. and Frank, B.H. (1985): Receptor binding and biological potency of several split forms (conversion intermediates) of human proinsulin. Studies in cultured IM-9 lymphocytes and in vivo and in vitro in rats. J. Biol. Chem., 260, 13989-13994.
33. [33] Phillips, D.I.W., Barker, D.J.P., Hales, C.N., Hirst, S. and Osmond, C. (1994): Thinness at birth and insulin resistance in adult life. Diabetologia, 37, 150-154.
34. [34] Phillips, D.I.W., Hirst, S., Clark, P.M.S., Hales, C.N. and Osmond, C. (1994): Fetal growth and insulin secretion in adult life. Diabetologia, 37, 592-596.
35. [35] Phipps, K., Barker, D.J.P., Hales, C.N., Fall, C.H.D., Osmond, C. and Clark, P.M.S. (1993): Fetal growth and impaired glucose tolerance in men and women. Diabetologia, 36, 225-228.
36. [36] Polonsky, K.S., Given, B.D., Hirsch, L.J., Tillil, H., Shapiro, E.T., Beebe, C. et al. (1988): Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. New Engl. J. Med., 318, 1231-1239.
37. [37] Robinson, J.S., Hart, I.C., Kingstone, J., Jones, C.T. and Thornburn, G.D. (1980): Studies on the growth of the fetal sheep. The effects of reduction of placental size on hormone concentrations in fetal plasma. J. Dev. Physiol., 2, 239-248.
38. [38] Simmons, D. (1994): Differences in umbilical cord insulin and birth weight in non-diabetic pregnancies of women from different ethnic groups in New Zealand. Diabetologia, 37, 930-936.
39. [39] Sizenko, S., Irminger, J.C., Buhler, L., Deng, S., Morel, P. and Halban, P.A. (1993): Kinetics of proinsulin conversion in human islets. Diabetes, 42, 933-936.
40. [40] Sobey, W.J., Beer, S.F., Carrington, C.A., Clark, P.M.S., Frank, B.H. and Gray, P. et al. (1989): Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 and 32-33 split proinsulin. Biochem. J., 260, 535-541.
41. [41] Swenne, I. (1992): Pancreatic beta-cell growth and diabetes mellitus. Diabetologia, 35, 193-201.
42. 31P magnetic resonance spectroscopy. Diabetologia, 38, 1205-1212.
43. [43] Valdez, R., Athens, M.A., Thompson, G.H., Bradshaw, R.S. and Stern, MP. (1994): Birthweight and adult health outcomes in a biethnic population in the USA. Diabetologia, 37, 624-631.
44. [44] Godfrey, K.M., Robinson, S., Hales, C.N., Barker, D.J.P., Osmond, C., Taylor, K.P. (1996): Nutrition in pregnancy and the concentrations of proinsulin 32-33 split proinsulin, insulin and C-peptide in cord plasma. Diabetic. Med. In press.