Identification and stereochemistry of the product of 4-HPPD catalyzed oxidation of the ketoacid of methionine

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 16, 1996, Pages 2003-2006

  Adlington, Robert M ^a   Baldwin, Jack E ^a   Crouch, Nicholas P ^a   Lee, Meng Huee ^a   MacKinnon, Colin H ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE DERIVATIVE;

ARTICLE; CHIRALITY; CIRCULAR DICHROISM; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0030594980     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00362-9     Document Type: Article

References (7)

1. 1) Sabourin, P. J.; Bieber, L. L. J. Biol Chem., 1982, 257, 7460 and references cited therein
2. 2) Baldwin, J. E.; Crouch, N. P.; Fujishima, Y.; Lee, M.-H.; MacKinnon, C. H.; Pitt, J. P. N.; Willis, A. C. Bioorg. Med. Chem. Lett., 1995, 5, 1255
3. 3) Baldwin, J. E.; Crouch, N. P.; Lee, M.-H.; MacKinnon, C. H.; Zhang, Z. H. Bioorg. Med. Chem. Lett., 1996, 6, 1503
4. 4) Doi, J. T.; Goodrow, M. H.; Musker, W. K. J. Org. Chem., 1986, 51, 1026
5. 5) Duñach, E.; Kagan, H. B. Nouv. J. Chim., 1985, 9, 1
6. 6) Deshmukh, M.; Duñach, E.; Juge, S.; Kagan, H. B. Tet. Lett., 1984, 25, 3467
7. 7) Pascal et al have demonstrated the 4-HPPD catalyzed oxidative decarboxylation of synthetic [(4-hydroxyphenyl)thio]pyruvate to [(4-hydroxyphenyl)sulfinyl]acetate, see Pascal, R.A.; Oliver, M.A.; Chen, Y.-C. J. Biochemistry 1985, 24, 3158