Utilization of Wieland furoxan synthesis for preparation of 4-aryl-1,2,5-oxadiazole-3-yl carbamate derivatives having potent anti-HIV activity

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 16, 1996, Pages 1993-1996

  Takayama, Hiromitsu ^a   Shirakawa, Seiichiro ^a   Kitajima, Mariko ^a   Aimi, Norio ^a   Yamaguchi, Kentaro ^a   Hanasaki, Yasuaki ^b   Ide, Teruhiko ^b   Katsuura, Kimio ^b   Fujiwara, Masatoshi ^c   Ijichi, Katsushi ^c   Konno, Kenji ^c   Sigeta, Shiro ^d   Yokota, Tomoyuki ^c   Baba, Masanori ^e  

^a CHIBA UNIVERSITY   (Japan)

^b TOSOH CORPORATION   (Japan)

^c Rational Drug Design Laboratories   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^e KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FURAZAN DERIVATIVE; FUROXAN DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030594965     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00355-1     Document Type: Article

References (13)

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10. 2O (equation presented)
11. 10. All new compounds gave satisfactory spectral and analytical (combustion or high resolution mass spectral) data consistent with the structures shown.
12. 3, Z=2. All measurements were made using a Rigaku AFC5S diffractometer with graphite monochromated Cu-Kα radiation with the ω-2θ scan technique to a maximum 2θ value of 131.9°. Of the 2519 reflections which were collected, 2332 were unique. The final R factor is 0.057 (Rw=0.059).The refined fractional atomic coordinates, the bond lengths, the bond angles, and thermal parameters of compounds 10 and 16 have been deposited at the Cambridge Crystallographic Data Centre.
13. 12. Mukaiyama, T.; Nambu, H. Okamoto, M. J. Org. Chem. 1962, 27, 3651.