Effects of galanin 8-OH-DPAT induced decrease in body temperature and brain 5-hydroxytryptamine metabolism in the mouse

European Journal of Pharmacology

Volumn 317, Issue 2-3, 1996, Pages 197-204

  Patel, Shil ^a   Hutson, Peter H ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

5 HT(1A) receptor; 8 OH DPAT (8 hydroxy 2 (di n propylamino)tetralin); Acetylcholine; Galanin; Hypothermia; Muscarinic receptor

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; GALANIN; GALANIN RECEPTOR; GLIBENCLAMIDE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; POTASSIUM CHANNEL BLOCKING AGENT; SCOPOLAMINE; SEROTONIN; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; HYPOTHERMIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MONOAMINE METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; THERMOREGULATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BODY TEMPERATURE REGULATION; BRAIN CHEMISTRY; CEREBRAL CORTEX; GALANIN; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED STRAINS; MUSCARINIC ANTAGONISTS; PIPERAZINES; POTASSIUM CHANNELS; PYRIDINES; RECEPTORS, GALANIN; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, SEROTONIN; SCOPOLAMINE; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030593938     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00716-9     Document Type: Article

References (44)

1. Bartfai, T., K. Bedecs, T. Land, U. Langel, R. Bertorelli, P. Girotti, S. Consolo, X.J. Xu, Z. Wiesenfeldhallin, S. Nilsonn, V.A. Pieribone and T. Hokfelt, 1991, M-15 - high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus-coeruleus, and spinal cord, Proc. Natl. Acad. Sci. USA 88, 10961.
2. Bedecs, K., U. Langel and T. Bartfai, 1995, Metabolism of galanin and galanin (1-16) in isolated cerebrospinal fluid and spinal cord membranes from rat, Neuropeptides 29, 137.
3. Bill, D.J., M. Knight, E.A. Forster and A. Fletcher, 1991, Direct evidence for an important species difference in the mechanism of 8-OH-DPAT induced hypothermia, Br. J. Pharmacol. 103, 1857.
4. 1A receptor coupling to adenylyl cyclase in discrete regions of the rat brain, Eur. J. Pharmacol. 269, 209.
5. Boess, F.G. and I.L. Martin, 1994, Molecular biology of 5-HT receptors, Neuropharmacology 33, 275.
6. Bradford, M., 1976, A method to measure protein concentrations, Anal. Biochem. 72, 248.
7. 50) of an enzymatic reaction, Biochem. Pharmacol. 22, 3099.
8. Consolo, S., R. Bertorelli, P. Girotti, C. LaPorta, T. Bartfai, M. Parenti and M. Zambelli, 1991, Pertussis toxin-sensitive G-protein mediates galanin's inhibition of scopolamine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus, Neurosci. Lett. 126, 29.
9. 2 adrenoreceptor antagonists, Br. J. Pharmacol. 102, 222.
10. Fisone, G., C.F. Wu, S. Consolo, O. Nordstrom, N. Byrnne, T. Bartfai, T. Melander and T. Hokfelt, 1987, Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo and in vitro studies, Proc. Natl. Acad. Sci. USA 84, 7339.
11. Fisone, G., C.F. Bartfai, T. Bartfai, S. Nilsson and T. Hokfelt, 1991, Galanin inhibits the potassium-evoked release of acetylcholine and the muscarinic receptor mediated stimulation of phosphoinositide turnover in slices of monkey brain, Brain Res. 568, 279.
12. 1A receptor antagonist, Br. J. Pharmacol. 112, P91.
13. Freedman, S.B., E.A. Harley and S. Patel, 1989, Direct measurement of muscarinic agents in the central nervous system of mice using ex vivo binding, Eur. J. Pharmacol. 174, 253.
14. Fuxe, K., S.-O. Ogren, A. Jansson, A. Cintra, A. Harfstrand and L.F. Agnati, 1988a, Intraventricular injections of galanin reduces 5-HT metabolism in the ventral limbic cortex, the hippocampal formation and the frontoparietal cortex of the male rat, Acta Physiol. Scand. 133, 579.
15. Fuxe, K., G. Von Euler, L.F. Agnati and S.-O. Ogren, 1988b, Galanin selectively modulates 5-hydroxytryptamine 1A receptors in the rat ventral limbic cortex, Neurosci. Lett. 85, 163.
16. Goodwin, G.M., R.J. DeSouza and A.R. Green, 1985, Presynaptic serotonin receptor mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock, Nature 317, 531.
17. 3H-PAT, Nature 305, 140.
18. Hedlund, P.B., N. Yanaihara and K. Fuxe, 1992, Evidence for specific N-terminal galanin fragment binding sites in the rat brain, Eur. J. Pharmacol. 224, 203.
19. 1A receptors in the dorsal hippocampus of the rat brain: possible existence of galanin receptor subtypes, Brain Res. 634, 163.
20. Hjorth, S., 1985, Hypothermia in rat induced by the potent serotoninergic agent 8-OH-DPAT, J. Neural Transm. 61, 131.
21. Hjorth, S., A. Carlsson, P. Lindeberg, D. Sanchez, H. Wikstrom, L.-E. Arvidsson, U. Hacksell and J.L.G. Nilsson, 1982, 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT receptor stimulating activity, J. Neural Transm. 55, 169.
22. 1A agonists LY 165163 and 8-OH-DPAT is not prevented by 5-HT depletion, Eur. J. Pharmacol. 143, 221.
23. Hutson, P.H., T.P. Donohoe and G. Curzon, 1987b, Neurochemical and behavioural evidence for an agonist action of 1-[2-(4-aminophenyl)ehyl]-4-(3-trifluromethylphenyl)piperazine (LY 165163) at central 5-HT receptors, Eur. J. Pharmacol. 138, 215.
24. Hutson, P.H., G.S. Sarna, M.T. O'Connell and G. Curzon, 1989, Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OH-DPAT into the nucleus raphe dorsalis, Neurosci. Lett. 100, 276.
25. 1A receptor enhances acetylcholine release in conscious rats, J. Neurochem. 62, 1804.
26. 1A autoreceptor response and its evaluation as a model to selectively identify antidepressants, Br. J. Pharmacol. 107, 15.
27. 3H]5-hydroxytryptamine from rat hypothalamic synaptosomal preperations, Neurosci. Lett. 122, 87.
28. Melander, T., W.M. Staines, T. Hokfelt, A. Rokaeus, F. Eckenstein, P.M. Salvaterra and B.H. Wainer, 1985, Galanin-like immunoreactivity in cholinergic neurones of septum-basal forebrain complex projecting to the hippocampus of the rat, Brain Res. 360, 130.
29. Melander, T., T. Hokfelt and A. Rokaeus, 1986a, Distribution of galanin immunoreactivity in the rat central nervous system, J. Comp. Neurol. 248, 475.
30. Melander, T., T. Hokfelt, A. Rokaeus, A.C. Cuello, W.H. Oertel, A. Verhofstad and M. Goldstein, 1986b, Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS, J. Neurosci. 6, 3640.
31. 125I-galanin binding sites in the central nervous system, J. Chem. Neuroanat. 1, 213.
32. Palazzi, E., G. Fisone, T. Hokfelt, T. Bartfai and S. Consolo, 1988, Galanin inhibits the muscarinic stimulation of phosphoinositide turnover in rat ventral hippocampus, Eur. J. Pharmacol. 148, 479.
33. 2+ channels, J. Neurochem. 56, 739.
34. + channels, Eur. J. Pharmacol. 255, 25.
35. Pazos, A. and J.M. Palacios, 1985, Quantitative autoradiographic mapping of sertonin receptors in the rat brain. I. Serotonin-1 receptors, Brain Res. 346, 205.
36. 1A receptor agonist, on cortical acetylcholine release, electrocardiogram and body temperature in guinea pigs and rats, Eur. J. Pharmacol. 175, 219.
37. Skofitsch, G. and D.M. Jacobwitz, 1985, Immunohistochemical mapping of galanin-like neurons in the rat central nervous sytem, Peptides 6, 509.
38. 125I galanin binding sites in the rat central nervous system, Peptides 7, 1029.
39. 1A selective agonists, Eur. J. Pharmacol. 128, 295.
40. Sundstrom, E. and T. Melander, 1988, Effects of galanin on 5-HT neurons in the rat CNS, Eur. J. Pharmacol. 146, 327.
41. Tatemoto, K., A. Rokaeus, H. Jornvall, T.J. McDonald and V. Mutt, 1983, Galanin - a novel biologically active peptide from porcine intestine, FEBS Lett. 164, 124.
42. 1A subtype, Eur. J. Pharmacol. 113, 463.
43. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats, J. Neurosci. 6, 3474.
44. 1A receptor activation increases hippocampal acetylcholine efflux and motor actvity in guinea pig: agonist efficacy influences functional activity in vivo, J. Pharmacol. Exp. Ther. 270, 656.