Repeated treatment with adenosine A1 receptor agonist and antagonist modifies the anticonvulsant properties of CPPene

European Journal of Pharmacology

Volumn 317, Issue 2-3, 1996, Pages 239-245

  De Sarro, Giovambattista ^a   Donato Di Paola, Eugenio ^a   Falconi, Umberto ^a   Ferreri, Guido ^a   De Sarro, Angela ^b  

^a UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

2 chloro N6 cyclopentyladenosine (CCPA); 2 hexnyl 5' N ethylcarboxamidoadenosine (2HE NECA); 3 (2 carboxypiperazine 4y)orpoenyl 1 phosphonic acid (cppENE); 5 N ethylcarboxamidoadenosine (NECA); 8 cyclopentyl 1,3 dipropylxanthine (DPCPX); Adenosine A1 receptor agonist; Adenosine A1 receptor antagonist; Adenosine A2 receptor agonist; Adenosine A2 receptor antagonist; Adenosine analog; Audiogenic seizure; DBA 2 mouse; Epilepsy; SCH 58261; Seizure

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; SCH 5826; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; AUDITORY STIMULATION; CONTROLLED STUDY; DRUG POTENTIATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ACOUSTIC STIMULATION; ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED DBA; PIPERAZINES; PYRIMIDINES; RECEPTORS, PURINERGIC P1; TRIAZOLES; XANTHINES;

EID: 0030593922     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00746-7     Document Type: Article

References (41)

1. 2 receptor-mediated functions in rat brain slices, Drug Dev. Res. 28, 364.
2. 2 receptor mediated functions in rat brain slices, Int. J. Purine Pyrimidine Res. 1, 39 (Abstract).
3. 2 receptor agonists on pentylenetetrazole-induced convulsions in the rat, Eur. J. Pharmacol. 294, 383.
4. Barraco, R.A., T.H. Swanson, J.W. Phillis and R.F. Berman, 1986, Anticonvulsant effects of adenosine analogs on amygdaloid-kindled seizures in rats, Neurosci. Lett. 46, 317.
5. Berman, R.F., M.F. Jarvis and C.R. Lupica, 1990, Adenosine involved in kindled seizures, in: Kindling, Vol. 4, ed. J.A. Wada (Plenum, New York) p. 423.
6. Brodie, M.S., K. Lee, B.B. Fredholm, L. Stahle and T.V. Dunwiddie, 1987, Central versus peripheral mediation of responses to adenosine receptor agonists: evidence against a central mode of action, Brain Res. 415, 323.
7. 1 selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes, Naunyn-Schmiedeberg's Arch. Pharmacol. 355, 59.
8. 1-mediated hemodynamic effects, J. Pharmacol. Exp. Ther. 268, 1506.
9. 1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain, J. Pharmacol. Exp. Ther. 267, 844.
10. Daval, J.L., A. Nehlig and F. Nicolas, 1991, Physiological and pharmacological properties of adenosine: therapeutic implications, Life Sci. 49, 1435.
11. De Sarro, G.B., A. Chimirri, A. De Sarro, R. Gitto, S. Grasso, P. Giusti and A. Chapman, 1995, GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice, Eur. J. Pharmacol. 294, 411.
12. De Sarro, G.B., M.J. Croucher and B.S. Meldrum, 1984, Anticonvulsant actions of DS 103-282: pharmacological studies in rodents and the baboon Papio papio, Neuropharmacology 23, 526.
13. De Sarro, G.B. and A. De Sarro, 1992, Anticonvulsant activity of competitive antagonists of NMDA receptor in genetically epilepsy-prone rats, Eur. J. Pharmacol. 215, 221.
14. De Sarro, G.B., A. De Sarro and B.S. Meldrum, 1991, Anticonvulsant action of 2-chloroadenosine injected focally into the inferior colliculus and substantia nigra, Eur. J. Pharmacol. 194, 145.
15. De Sarro, G.B., E. Donato Di Paola, E. Ongini, R. Bertorelli and A. De Sarro, 1996, Anticonvulsant and proconvulsant effects of compounds acting on different adenosine receptor subtypes in DBA/2 mice, Fund. Clin. Pharmacol. 10, 185 (Abstract).
16. De Sarro, G.B., B.S. Meldrum and G. Nisticò,1988, Anticonvulsant effects of some calcium entry blockers in DBA/2 mice, Br. J. Pharmacol. 93, 247.
17. De Sarro, G.B., E. Ongini, R. Bertorelli, U. Aguglia and A. De Sarro, 1994, Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice, Eur. J. Pharmacol. 262, 11.
18. Dragunow, M., 1991, Adenosine and epileptic seizures, in: Adenosine and Adenine Nucleotides as Regulators of Cellular Function, ed. J.W. Phillis (CRC, Boca Raton) p. 367.
19. Dragunow, M. and R.L.M. Faull, 1988, Neuroprotective effects of adenosine, Trends Pharmacol. Sci. 9, 193.
20. Dragunow, M., G.V. Goddard and R. Laverty, 1985, Is adenosine an endogenous anticonvulsant?, Epilepsia 26, 480.
21. Dunwiddie, T.V. and T. Worth, 1982, Sedative and anticonvulsant effects of adenosine analogs in mouse and rats, J. Pharmacol. Exp. Ther. 220, 70.
22. Durcan, M.J. and P.F. Morgan, 1989, NECA-induced hypomotility in mice: evidence for a predominantly central site of action, Pharmacol. Biochem. Behav. 32, 487.
23. Georgiev, V., B. Johansson and B.B. Fredholm, 1993, Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number, Brain Res. 612, 271.
24. Jacobson, K.A., D.K.J.E. Von Lubitz, J.W. Daly and B.B. Fredholm, 1996, Adenosine receptor ligands: differences with acute versus chronic treatment, Trends Pharmacol. Sci. 17, 108.
25. Litchfield, J.T. and F. Wilcoxon, 1949, A simplified method of evaluating dose-effects experiments, J. Pharmacol. Exp. Ther. 96, 99.
26. Miller, L.P. and C. Hsu, 1992, Therapeutic potential for adenosine receptor activation in ischemic brain injury, J. Neurotrauma 2, S 563.
27. 6-cyclopentyl-adenosine, Arzneim.-Forsch./Drug Res. 44, 1305.
28. 2 adenosine receptor agonist 2-hexynyl-5′-N-ethylcarboxamidoadenosine, Arzneim.-Forsch./Drug Res. 44, 1296.
29. 1 receptors, Brain Res. Bull. 27, 101.
30. Phillis, J.W. and P.H. Wu, 1983, The role of adenosine and its nucleotides in central synaptic transmission, Prog. Neurobiol. 16, 187.
31. 1 adenosine adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine injestion, J. Clin. Invest. 82, 242.
32. Ribeiro, J.A., 1991, Purinergic regulation of transmitter release, in: Adenosine and Adenine Nucleotides as Regulators of Cellular Function, ed. J.W. Phillis (CRC, Boca Raton) p. 155.
33. Rosen, J.B. and R.F. Berman, 1985, Prolonged postictal depression in amygdala-kindled into the adenosine analog L-phenyl-propyladenosine, Exp. Neurol. 90, 549.
34. Rudolphi, K.A., M. Keil, J. Fastbom, J.J. Grome and B.B. Fredholm, 1990, Contrary effects of acute versus chronic caffeine administration on ischemically induced hippocampal damage in gerbil. Involvement of adenosine receptors?, in: Purines in Cellular Signaling, eds. K.A. Jacobson, J.W. Daly and V. Manganiello (Springer, Berlin) p. 411.
35. Rudolphi, K.A., P. Schubert, F.E. Parkinson and B.B. Fredholm, 1992, Neuroprotective role of adenosine in cerebral ischemia, Trends Pharmacol. Sci. 13/12, 439.
36. 1 antagonist for treatment of cognitive deficits, Nucleosides Nucleotides 5, 1067.
37. Shi, D., O. Nikodijevic, K.A. Jacobson and J.W. Daly, 1993, Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA and serotonin receptors and calcium channels in mouse brain, Cell. Mol. Neurobiol. 13, 247.
38. 3 receptor stimulation on seizure in mice, Eur. J. Pharmacol. 275, 23.
39. 1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice, Eur. J. Pharmacol. 253, 95.
40. Von Lubitz, D.K.J.E., I.A. Paul and K.A. Jacobson, 1993a, Effects of chronic administration of adenosine agonist and antagonist on spatial learning in mice, Eur. J. Pharmacol. 249, 271.
41. 6-cyclopentyladenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice, Eur. J. Pharmacol. 249, 265.