A simple synthesis of biaryl phospholipase A2 inhibitors: Probing hydrophobic effects

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 22, 1996, Pages 2669-2672

  Springer, Dane M ^a   Bronson, Joanne J ^a   Mansuri, Muzammil M ^a,c   Nettleton, David O ^b,d   Tramposch, Kenneth M ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c GPC Biotech Inc   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CARBOXYPHENYL) 3,7 DIMETHYL 9 (2,6,6 TRIMETHYL 1 CYCLOHEXENYL) 2,4,6,8 NONATETRAENOIC ACID; ENZYME INHIBITOR; MANOALIDE; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKOCYTE; THROMBOCYTE;

EID: 0030593871     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00499-4     Document Type: Article

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40. 2, and the product was recrystallized from EtOAc/hexane to give a 20% yield of 7.
41. 2 assay protocol used in this work see reference 3d. Data determined at 100 μM and 10 μM was obtained in a high throughput screen and is the mean of two samples at each concentration.
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