Modified triphosphates of carbocyclic nucleoside analogues: Synthesis, stability towards alkaline phosphatase and substrate properties for some DNA polymerases

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 22, 1996, Pages 2639-2642

  Dyatkina, Natalya ^a   Shirokova, Elena ^a   Theil, Fritz ^b   Roberts, Stanley M ^c   Krayevsky, Alexander ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b Ctr of Selective Organic Synthesis   (Germany)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; CARBOCYCLIC NUCLEOSIDE; DNA NUCLEOTIDYLEXOTRANSFERASE; GUANOSINE TRIPHOSPHATE; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE 5' TRIPHOSPHATE;

ARTICLE; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; PLACENTA; STRUCTURE ACTIVITY RELATION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030593870     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00482-9     Document Type: Article

References (15)

1. 1. Krayevsky, A.A. Molec. Biol. Russian, 1994, 28, 1245 and references cited there in.
2. 2. Labataille, P.; Pelicano, H.; Maury, G.; Imbach, J.-L., Gosselin, G. Bioorg. & Med. Chem. Lett. 1995, 5, 2315.
3. 3. Merlo, V.; Roberts, S.M.; Storer, R.; Bethell, R. J. Chem. Soc. Perkin Trans I 1994, 1477.
4. 4. Semizarov, D.G.; Victorova, L.S.; Dyatkina, N.B.; von Janta-Lipinski, M.; Krayevsky, A.A. FEBS Lett. 1994, 354, 187.
5. 5. Chernov, D.N.; Skoblov, Yu. The paper submitted to Molec. Biol. Russian.
6. 6. Kilesso, T.M.; Tarussova, N.B.; Atrazheva, E.D.; Kukhanova, M.K.; Shulenin, S., Bobkov, A., Garaev, M., Galegov, G.A., Krayevsky, A.A. Bioorgan. Chem. Russian, 1990, 16, 530.
7. 3] (L3b).
8. 8. Dyatkina, N., Theil, F., von Janta-Lipinski, M. Tetrahedron, 1995, 51, 761.
9. 9. Spigelman, Z., Duff, R., Beardsley G.,P., Broder, S., Cooney, D., Lavden, M.R., Mitsuya, H., Ullman, B., Mc Caffrey, R. Blood, 1988, 71, 1601.
10. 10. Theil, F., Ballschuh, S., von Janta-Lipinski, M., Johnson, R.A. J. Chem. Soc. Perkin Trans. I, 1995, 255.
11. 3].
12. 12. Balzarini, J., Herdewijn, P., Pauwels, R., Broder, S., De Clercq, E. Biochem. Pharmacol., 1988, 37, 2395.
13. 13. Kuznetsova, E.V., Kukhanova, M.K., Arzumanov, A.A., Krayevsky, A.A. Molec. Biol. Russian, 1995, 29, 687.
14. 14. Elliott, R.D., Rener, G.A., Riordan, J.M., Secrist III, J.A., Lee Bennett, L., Parker, W.B., Montgomery, J.A. J. Med. Chem. 1994, 37, 739.
15. 15. Kukhanova, M., Tarussova, N., Jasko, M., Arzumanov, A., Gudima, S., Krayevsky, A., Chidzhavadzhe, Z., Beabealashvilly, R. Molec. Biol. Russian, 1992, 26, 1148.