Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1'-substituted analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 22, 1996, Pages 2705-2708

  Yamada, Akira ^a   Hattori, Kouji ^a   Kuroda, Satoru ^a   Chiba, Toshiyuki ^a   Kamimura, Toshiaki ^a   Sakane, Kazuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 VINYLCARBAPENEM; CARBAPENEM DERIVATIVE; IMIPENEM; METICILLIN; PEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOG; DRUG DESIGN; DRUG RESISTANCE; DRUG STABILITY; DRUG SYNTHESIS; DRUG URINE LEVEL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN TISSUE; MINIMUM INHIBITORY CONCENTRATION; MONKEY; MOUSE; RABBIT; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; BACTERIA (MICROORGANISMS); CANIS FAMILIARIS; NEGIBACTERIA; ORYCTOLAGUS CUNICULUS; POSIBACTERIA;

EID: 0030593868     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00495-7     Document Type: Article

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