Influence of the neurotoxin capsaicin on rat pancreatic islets in culture, and on the pancreatic islet blood flow of rats

European Journal of Pharmacology

Volumn 312, Issue 1, 1996, Pages 75-81

  Carlsson, Per Ola ^a,b   Sandler, Stellan ^a   Jansson, Leif ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Blood flow; Capsaicin; Insulin release; Pancreas; Pancreatic islet; Peptidergic neuron

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; NEUROTOXIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS ISLET CELL; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

EID: 0030593753     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00492-X     Document Type: Article

References (40)

1. Andersson, A. and S. Sandler, 1983, Viability tests of cryopreserved endocrine pancreatic cells, Cryobiology 20, 161.
2. Barja, F., R. Mathison and H. Huggel, 1983, Substance P containing nerve fibers in large peripheral blood vessels of the rat, Cell Tissue Res. 229, 411.
3. Donnerer, J. and F. Lembeck, 1982, Analysis of the effects of intravenously injected capsaicin in the rat, Naunyn-Schmiedeberg's Arch. Pharmacol. 320, 54.
4. Donnerer, J. and F. Lembeck, 1983, Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem, Naunyn-Schmiedeberg's Arch. Pharmacol. 324, 293.
5. Duckles, S.P., 1986, Effects of capsaicin on vascular smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 333, 59.
6. Erlandssen, S.L., J.A. Parsons, D.E. Van Orden and L.S. Van Orden, 1975, A modification of the unlabeled antibody enzyme method using heterologous antisera for light microscopic and ultratsructural localization of insulin, glucagon anf growth hormone, J. Histochem. Cytochem. 23, 666.
7. Furness, J.B., R.E. Papka, N.G. Della, M. Costa and R.L. Eskay, 1982, Substance P-like immunoreactivity in nerves associated with the vascular system of the guinea pigs, Neuroscience 7, 447.
8. Heding, L.G., 1972, Determination of total serum insulin (IRI) in insulin-treated patients, Diabetologia 8, 260.
9. Hendersson, J.M., W.J. Millikan, M. Hooks, B. Noe, M.H. Kutner and W.D. Warren, 1989, Increased galactose clearance after liver transplantation: a measure of increased blood flow through the denervated liver?, Hepatology 10, 288.
10. Hinegardner, R.T., 1971, An improved fluorometric assay for DNA. Anal. Biochem. 39, 197.
11. Holzer, P., 1988, Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonon gene-related peptide and other neuropeptides, Neuroscience 24, 739.
12. Hökfelt, T., O. Johansson, A. Ljungdahl, J.M. Lundberg and M. Schultzberg, 1980, Peptidergic neurones, Nature (London) 285, 515.
13. Jancso, N., A. Jancso-Gabor and J. Szolcsanyi, 1968, The role of sensory nerve endings in neurogenic inflammation induced in human skin and eye and paw of the rat, Br. J. Pharmacol. 33, 32.
14. Jancso, G., T. Hökfelt, J.M. Lundberg, E. Kiraly, N. Halasz, G. Nilsson, L. Terenius, J. Rehfeld, H. Steinbusch, A. Verhofstad, R. Elde, S. Said and M. Brown, 1981, Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP. enkephalin, neurotensin, and 5-hydroxytryptamine. J. Neurocytol. 10, 963.
15. Jansson, L., 1994, The regulation of pancreatic islet blood flow. Diabetes Metab. Rev. 10, 407.
16. Jansson, L., 1992, Whole pancreatic blood flow and islet blood flow in hypovolemic hypotension in rats, Eur. Surg. Res. 24, 291.
17. Jansson, L. and C. Hellerström, 1981, A rapid method of visualizing the pancreatic islets for studies of islet capillary flow using non-radioactive microspheres, Acta Physiol. Scand. 113, 371.
18. Jansson, L. and C. Hellerström, 1983, Stimulation by glucose of the blood flow through the pancreatic islets of the rat, Diabetologia 25, 45.
19. Jessel, T.M., L.L. Iversen and A.C. Cuello, 1978, Capsaicin induced depletion of substance P from primary sensory neurones, Brain Res. 152, 183.
20. Karlsson, S., F. Sundler and B. Ahrén, 1992, Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion, J. Auton. Nerv. Syst. 39, 51.
21. Karlsson, S., A.J. Scheurink, A.N. Steffens and B. Ahrén, 1994, Involvement of capsaicin-sensititive nerves in regulation of insulin secretion and glucose tolerance in conscious mice, Am. J. Physiol. 267, R1071.
22. Kvietys, P.R., J.M. McLendon, G.B. Bulkley, M.A. Perry and D.N. Granger, 1982, Pancreatic circulation: intrinsic regulation, Am. J. Physiol. 242, G596.
23. Li, D.-S., H.E. Raybould, E. Quintero and P.H. Guth, 1991, Role of calcitonon gene related peptide in gastric hyperemic response to intragastric capsaicin, Am. J. Physiol. 261, G657.
24. Lundberg, J.M. and A. Saria, 1983, Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants, Nature (London) 302, 251.
25. Makarara, B., L. Györgi and J. Molnar, 1967, Circulatory and respiratory responses to capsaicin, 5-hydroxytryptamine and histamine in rats pretreated with capsaicin, Arch. Int. Pharmacodyn. 170, 39.
26. Manzini, S. and F. Perretti, 1988, Vascular effects of capsaicin in isolated perfused rat mesenteric bed, Eur. J. Pharmacol. 148, 153.
27. Manzini, S., M. Tramontana and F. Perretti, 1991, Efferent function of capsaicin-sensitive nerves and neurogenic vasodilation in rat mesenteric circulation, in: Sensory Nerves and Neuropeptides in Gastroenterology (Plenum, New York) p. 241.
28. Perry, R.R., B.L. Bass, J.W. Harmon and V.F. Garcia, 1986, Blood flow to transplanted fetal rat intestine, J. Surg. Res. 41, 627.
29. Rozsa, Z., G. Jancso and V. Varro, 1984, Possible involvement of capsaicin-sensitive sensory neurones in the regulation of intestinal blood flow in the dog, Naunyn-Schmiedeberg's Arch. Pharmacol. 326, 352.
30. Sandler, S., A. Andersson and C. Hellerström, 1987, Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis and oxidative metabolism of isolated rat pancreatic islets, Endocrinology 121, 1424.
31. Saria, A., J.M. Lundberg, X. Hua and F. Lembeck, 1983, Capsaicin induced substance P release and sensory control of vascular permeability in the guinea pig ureter. Neurosci. Lett. 111, 167.
32. Schultzberg, M., G.J. Dockray and R.G. Williams, 1982, Capsaicin depletes CCK-like immunoreactivity detected by immunohistochemistry but not that measured by radioimmunoassay in rat dorsal spinal cord, Brain Res. 235, 198.
33. Scott, T.M., K.H. Drodge and J. Foote, 1992, Peptidergic nerve involvement in the control of endothelium-dependent vascular relaxation, Artery 19, 211.
34. Sharkey, K.A., R.G. Williams and G.J. Dockray, 1984, Sensory substance P innervation of the stomach and pancreas, Gastroenterology 87, 914.
35. Sternini, C. and N. Brecha, 1986, Immunocytochemical identification of islet cells and nerve fibers containing calcitonin gene-related peptide-like immunoreactivity in the rat pancreas, Gastroenterology 90, 1155.
36. Su, H.C., A.E. Bishop, R.F. Power, Y. Hamada and J.M. Polak, 1987, Dual intrinsic and extrinsic origins of CGRP- and NPY-immunoreactive nerves of rat gut and pancreas, J. Neurosci. 7, 2674.
37. Sundler, F. and G. Böttcher, 1991, Islet innervation, with special reference to neuropeptides, in: The Endocrine Pancreas, ed. E. Samols (Raven, New York) p. 29.
38. Svensson, A.M., S. Sandler and L. Jansson, 1994, Pancreatic islet blood flow in the rat after administration of islet amyloid polypeptide or calcitonin gene-related peptide, Diabetes 43, 454.
39. Toda, N., H. Usui, N. Nishino and M. Fujiwara, 1972, Cardiovascular effects of capsaicin in dogs and rabbits, J. Pharmacol. Exp. Ther. 181, 512.
40. White, T.P., L.C. Maxwell, D.M. Sosin and J.A. Faulkner, 1981, Capillarity and blood flow of skeletal muscle of cats, Am. J. Physiol. 241, H630.