Ethanol inhibits chemoreflex excitation of reticulospinal vasomotor neurons

Brain Research

Volumn 730, Issue 1-2, 1996, Pages 182-192

  Sun, Miao Kun ^a   Reis, Donald J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

alcohol; chemoreflex; excitatory amino acid; rat; rostral ventrolateral medulla; vasomotor neuron

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; ALCOHOL; N METHYL DEXTRO ASPARTIC ACID; NITROPRUSSIDE SODIUM; SODIUM CYANIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MALE; MEDULLA OBLONGATA; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE; VASOMOTOR REFLEX;

EID: 0030593685     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00445-3     Document Type: Article

References (43)

1. [1] Adbel-Rahman, A.A., Differential effects of ethanol on baroreceptor heart rate responses of conscious spontaneously hypertensive and normotensive rats, Alcohol Clin. Exp. Res., 18 (1994) 1515-1522.
2. [2] Amano, M., Asari, T. and Kubo, T., Excitatory amino acid receptors in the rostral ventrolateral medulla mediate hypertension induced by carotid body chemoreceptor stimulation, Naunyn-Schmiedeberg's Arch. Pharmacol., 349 (1994) 549-554.
3. [3] Beilin, L.J., Alcohol, hypertension and cardiovascular disease, J. Hypertension, 13 (1995) 939-942.
4. [4] Böhmer, G., Schmid, K. and Schauer, W., Evidence for an involvement of NMDA and non-NMDA receptors in synaptic excitation of phrenic motoneurons in the rabbit, Neurosci. Lett., 130 (1991) 271-274.
5. [5] Deitrich, R.A., Dunwiddie, T.V., Harris, R.A. and Erwin, V., Mechanism of action of ethanol: initial central nervous system actions, Pharmacol. Rev., 41 (1989) 489-537.
6. [6] Dogaš, Z., Stuth, E.A.E., Hopp, F.A., McCrimmon, D.R. and Zuperku, E.J., NMDA receptor-mediated transmission of carotid body chemoreceptor input to expiratory bulbospinal neurones in dogs, J. Physiol., 487 (1995) 639-651.
7. [7] el Mas, M.M. and Abdel-Rahman, A.A., Role of aortic baroreceptors in ethanol-induced impairment of baroreflex control of heart rate in conscious rats, J. Pharmacol Exp. Ther., 262 (1992) 157-165.
8. [8] Givens, B. and McHahon, K., Ethanol suppresses the induction of long-term potentiation in vivo, Brain Res., 688 (1995) 27-33.
9. [9] Gonzales, R.A., NMDA receptors excite alcohol research, Trends Pharmacol. Sci., 11 (1990) 137-139.
10. [10] Hoffmann, P.L., Rabe, C.S., Moses, F. and Tabakoff, B., N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production, J. Neurochem., 52 (1989) 1937-1940.
11. [11] Iwase, S., Matsukawa, T., Ishihara, S., Tanaka, A., Tanabe, K., Danbara, A., Matsuo, M., Sugiyama, Y. and Mano, T., Effect of oral ethanol intake on muscle sympathetic nerve activity and cardiovascular functions in humans, J. Auton. Nerv. Syst., 54 (1995) 206-214.
12. [12] King, A.C., Errico, A.L., Parsons, O.A. and Lovallo, W.R., Blood pressure dysregulation associated with alcohol withdrawal, Alcohol Clin. Exp. Res., 15 (1991) 478-482.
13. [13] Koshiya, N., Huangfu, D. and Guyenet, P.G., Ventrolateral medulla and sympathetic chemoretlex in the rat, Brain Res., 609 (1993) 174-184.
14. [14] Kubo, T., Amano, M. and Asari, T., N-Methyl-D-aspartate receptors but not non-N-methyl-D-aspartate receptor mediate hypertension induced by carotid body chemoreceptor stimulation in the rostral ventrolateral medulla of the rat, Neurosci. Lett., 164 (1993) 113-116.
15. [15] Kuwaki, T., Kurihara, Y., Kurihara, H., Yazaki, Y. and Kumada, M., Role of endothelin in central cardiorespiratory control: modern and classical approaches, News Physiol. Sci., 10 (1995) 228-233.
16. [16] Lovinger, D.M., White, G. and Weight, F.F., Ethanol inhibits NMDA-activated ion current in hippocampal neurons, Science, 243 (1989) 1721-1724.
17. [17] Lovinger, D.M., White, G. and Weight, F.F., NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat, J. Neurosci., 10 (1990) 1372-1379.
18. [18] Madamba, S.G., Hsu, M., Schweitzer, P. and Siggins, G.R., Ethanol enhances muscarinic neurotransmission in rat hippocampus in vitro, Brain Res., 685 (1995) 21-32.
19. [19] Morrisett, R.A. and Swartzwelder, H.S., Attenuation of hippocampal long-term potentiation by ethanol: A patch-clamp analysis of glutamatergic and GABAergic mechanisms, J. Neurosci., 13 (1993) 2264-2272.
20. [20] Netzeband, J. and Gruol, D.L., Modulatory effects of acute ethanol on metabotropic glutamate responses in cultured Purkinje neurons, Brain Res., 688 (1995) 105-113.
21. [21] Palmer, A.J., Fletcher, A.E., Bulpitt, C.J., Beevers, D.G., Coles, E.C., Ledingham, J.G.G., Petrie, J.C., Webster, J. and Dollery, C.T., Alcohol intake and cardiovascular mortality in hypertensive patients: report from the Department of Health Hypertension Care Computing Project, J. Hypertension, 12 (1995) 957-964.
22. [22] Puddey, I.B., Beilin, L.J., Vandongen, R., Rouse, I.L. and Rogers, P., Evidence for a direct effect of alcohol consumption on blood pressure in normotensive men - A randomized controlled trial, Hypertension, 7 (1985) 707-713.
23. [23] Rabe, L.S. and Tabkoff, B., Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor, Mol. Pharmacol., 38 (1990) 753-757.
24. [24] Saunders, J.B., Beevers, D.G. and Paton, A., Alcohol-induced hypertension, Lancet ii, (1981) 653-656.
25. [25] Sinclair, J.G. and Lo, G.F., Ethanol blocks tetanic and calcium-induced long-term potentiation in the hippocampal slice, Gen. Pharmacol., 17 (1986) 231-233.
26. [26] Steffenson, S.C., Yeckel, M.F., Miller, D.R. and Henriksen, S.J., Ethanol-induced suppression of hippocampal long-term potentiation is blocked by lesions of the septohippocampal nucleus. Alcohol: Clin. Exp. Res., 17 (1993) 655-659.
27. [27] Sun, M.-K., Central neural organization and control of sympathetic nervous system in mammals, Prog. Neurobiol., 47 (1995) 157-233.
28. [28] Sun, M.-K. and Guyenet, P.G., GABA-mediated baroreceptor inhibition of reticulospinal neurons, Am. J. Physiol., 249 (1989) R672-R680.
29. [29] Sun, M.-K. and Guyenet, P.G., Hypothalamic glutamatergic inputs to medullary sympathoexcitatory neurons in rat, Am. J. Physiol., 251 (1986) R798-R810.
30. [30] Sun, M.-K. and Reis, D.J., Hypoxic excitation of medullary vasomotor neurons are not mediated by glutamate or nitric oxide, Neurosci. Lett., 157 (1993) 219-222.
31. [31] Sun, M.-K. and Reis, D.J., Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia, Prog. Neurobiol., 44 (1994) 197-219.
32. 2+ currents in pacemaker neurones of rat rostral ventrolateral medulla in vitro, J. Physiol., 476 (1994) 101-116.
33. [33] Sun, M.-K. and Reis, D.J., Effects of systemic ethanol on medullary vasomotor neurons and baroreflexes, Neurosci. Lett., 137 (1992) 232-236.
34. [34] Sun, M.-K and Reis, D.J., NMDA receptor-mediated sympathetic chemoreflex excitation of RVL-spinal vasomotor neurones in rats, J. Physiol., 482 (1995) 53-68.
35. [35] Sun, M.-K. and Reis, D.J., Excitatory amino acid-mediated chemoreflex excitation of respiratory neurones in rostral ventrolateral medulla in rats, J. Physiol., 492 (1996) 559-571.
36. [36] Sun, M.-K. and Spyer, K.M., Responses of RVL-spinal vasomotor neurones to chemoreceptor stimulation in rats, J. Auton. Nerv. Syst., 33 (1991) 79-84.
37. [37] Sun, M.-K. and Spyer, K.M., GABA-mediated inhibition of medullary vasomotor neurones by area postrema stimulation in rats, J. Physiol., 436 (1991) 669-684.
38. [38] Sun, M.-K. and Spyer, K.M., Nociceptive inputs into rostral ventrolateral medullospinal vasomotor neurones in rats, J. Physiol., 436 (1991) 685-700.
39. [39] Sun, M.-K., Hackett, J.T. and Guyenet, P.G., Sympathoexcitatory neurons of rostral ventrolateral medulla exhibit pacemaker properties in the presence of a glutamate-receptor antagonist, Brain Res., 438 (1988) 23-40.
40. R1 receptor subunit immunoreactivity in rat hippocampus, J. Neurochem., 62 (1994) 1635-1638.
41. [41] Varga, K. and Kunos, G., Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors, Br. J. Pharmacol., 101 (1990) 773-775.
42. B receptors in the brainstem of the rat, Eur. J. Pharmacol., 214 (1992) 223-232.
43. [43] Varga, K., Gantenberg, N.S. and Kunos, G., Endogenous gamma-aminobutyric acid (GABA) mediates ethanol inhibition of vagally mediated reflex bradycardia elicited from aortic baroreceptors, J. Pharmacol. Exp. Ther., 268 (1994) 1057-1062.