Block of the endplate acetylcholine receptor channel by the sympathomimetic agents ephedrine, pseudoephedrine, and albuterol

Brain Research

Volumn 740, Issue 1-2, 1996, Pages 346-352

  Milone, Margherita ^a   Engel, Andrew G ^a  

^a MAYO CLINIC   (United States)

Author keywords

acetylcholine receptor; catecholamine; channel block; neuromuscular transmission; patch clamp analysis

Indexed keywords

ACETYLCHOLINE; CHOLINERGIC RECEPTOR; EPHEDRINE; ION CHANNEL; PSEUDOEPHEDRINE; SALBUTAMOL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; NEUROMUSCULAR DISEASE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

ALBUTEROL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPHEDRINE; ION CHANNELS; MEMBRANE POTENTIALS; RATS; RECEPTORS, CHOLINERGIC;

EID: 0030592686     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)00894-3     Document Type: Article

References (22)

1. [1] Baselt, R.C. and Cravey, R.H., Disposition of Toxic Drugs and Chemicals in Man, 3rd edn., Year Book Medical Publishers, Chicago, IL, 1989, pp. 320-322.
2. [2] Bowman, W.C. and Raper, C., Effects of sympathomimetic amines on neuromuscular transmission, Br. J. Pharmacol., 27 (1966) 313-332.
3. [3] Colquhoun, D. and Sigworth, F.J., Fitting and statistical analysis of single-channel records. In B. Sakmann and E. Neher (Eds.), Single Channel Recording, 2nd edn., Plenum, New York, 1995, pp. 483-587.
4. [4] Dilger, J.P., Brett, R.S. and Lesko, L.A., Effects of isoflurane on acetylcholine receptor channels. 1. Single-channel currents, Mol. Pharmacol., 41 (1992) 127-133.
5. [5] Dreyer, F., Acetylcholine receptor, Br. J. Anaesth., 54 (1982) 115-130.
6. [6] Edgeworth, H., A report of progress on the use of ephedrine in a case of myasthenia gravis, J. Am. Med. Assoc., 94 (1930) 1136.
7. [7] Edgeworth, H., The effect of ephedrine in the treatment of myasthenia gravis: second report, J. Am. Med. Assoc., 100 (1933) 1401.
8. [8] Engel, A.G., Myasthenia gravis and myasthenic syndromes. In L.P. Rowland and S. DiMauro (Eds.), Handbook of Clinical Neurology, 2nd edn., Elsevier, New York, 1992, pp. 391-455.
9. [9] Engel, A.G., Lambert, E.H., Mulder, D.M., Torres, C.F., Sahashi, K., Bertorini, T.E. and Whitaker, J.N., A newly recognized congenital myasthenic syndrome attributed to a prolonged open time of the acetylcholine-induced ion channel, Ann. Neurol., 11 (1982) 553-569.
10. [10] Felice, K.J. and Relva, G.M., Ephedrine in the treatment of congenital myasthenic syndrome, Muscle Nerve, 19 (1996) 799-800.
11. [11] Haukkamaa, M., Gummerus, M. and Kleimola, T., Serum salbutamol concentrations during oral and intravenous treatment in pregnant women, Br. J. Obstet. Gynaecol., 92 (1985) 1230-1233.
12. [12] Hutchinson, D.O., Walls, T.J., Nakano, S., Camp, S., Taylor, P., Harper, C.M., Groover, R.V., Peterson, H.A., Jamieson, D.G. and Engel, A.G., Congenital endplate acetylcholinesterase deficiency, Brain, 116 (1993) 633-653.
13. [13] Magleby, K.L. and Stevens, C.F., A quantitative description of end-plate currents, J. Physiol., 223 (1972) 173-197.
14. [14] Midha, K.K., Cooper, J.K. and McGilveray, I.J., Simple and specific electron capture GLC assay for plasma and urine ephedrine concentrations follwing single doses, J. Pharm. Sci., 68 (1979) 557-560.
15. [15] Murrell, R.D., Braun, M.S. and Haydon, D.A., Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes, J. Physiol., 437 (1991) 431-448.
16. [16] Neher, E. and Steinbach, J.H., Local anaesthetics transiently block currents through single acetylcholine-receptor channels, J. Physiol., 211 (1978) 153-176.
17. [17] Ogden, D.C. and Colquhoun, D., Ion channel block by acetylcholine, carbachol and suberidylcholine at the frog neuromuscular junction, Proc. R. Soc. London, Ser. B, 225 (1985) 329-355.
18. [18] Ohno, K., Hutchinson, D.O., Milone, M., Brengman, J.M., Bouzat, C., Sine, S.M. and Engel, A.G., Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the ∈ subunit, Proc. Natl. Acad. Sci. USA, 92(1995) 758-762.
19. [19] Sakmann, B., Patlak, J. and Neher, E., Single acetylcholine-activated channels show burst kinetics in the presence of desensitizing concentrations of agonist, Nature, 286 (1980) 71-73.
20. [20] Sieb, J.P. and Engel, A.G., Ephedrine: effects on neuromuscular transmission, Brain Res., 623 (1993) 167-171.
21. [21] Sine, S.M., Ohno, K., Bouzat, C., Auerbach, A., Milone, M., Pruitt, J.N. and Engel, A.G., Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity, Neuron, 15 (1995) 229-239.
22. 1 adrenoceptors, Arch. Pharmacol., 343 (1991) 435-438.