Effects of a xanthine derivative, propentofylline, on local cerebral blood flow and glucose utilization in the rat

Brain Research

Volumn 740, Issue 1-2, 1996, Pages 41-46

  Grome, John J ^a   Hofmann, Wolfgang ^a   Gojowczyk, Gerlinde ^a   Stefanovich, Vladimir ^a  

^a SANOFI   (France)

Author keywords

adenosine; cerebral blood flow; glucose utilization; propentofylline

Indexed keywords

PROPENTOFYLLINE; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN REGION; CONTROLLED STUDY; GLUCOSE UTILIZATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ULCER AGENTS; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; MALE; RATS; RATS, SPRAGUE-DAWLEY; XANTHINES;

EID: 0030592682     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)00353-8     Document Type: Article

References (41)

1. [1] Andine, P., Rudolphi, K.A., Fredholm, B.B. and Hagberg, H., Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia, Br. J. Pharmacol., 100 (1990) 814-818.
2. [2] Born, G.V.R., Strong inhibition by 2-chloroadenosine of the aggregation of blood platelets by adenosine diphosphate, Nature, 202 (1964) 95-96.
3. 1 receptors, guanine nucleotide and forskolin binding sites following transient brain ischaemia: a quantitative autoradiographic study, Brain Res., 491 (1989) 212-226.
4. [4] DeLeo, J., Schubert, P. and Kreutzberg, G.W., Propentofylline (HWA 285) protects hippocampal neurons of Mongolian gerbils against ischaemic damage in the presence of an adenosine antagonist, Neurosci. Lett., 84 (1988) 307-311.
5. [5] DeLeo, J., Toth, L., Schubert, P., Rudolphi, K. and Kreutzberg, G.W., Ischaemia induced neuronal cell death, calcium accumulation and glial response in the hippocampus of the Mongolian gerbil and protection by propentofylline (HWA 285), J. Cereb. Blood Flow Metab., 1 (1987) 745-752.
6. [6] Dragunow, M., Adenosine: the brains natural anticonvulsant? Trends Pharmacol. Sci., 7 (1986) 128-130.
7. [7] Dunnwiddie, T.V., Hoffer, B.J. and Fredholm, B.B., Alkyxanthines elevate hippocampal excitement, Naunyn-Schmiedebergs Arch. Pharmacol., 316 (1981) 326-330.
8. [8] Dux, E., Fastbom, J., Ungerstedt, U., Rudolphi, K. and Fredholm, B.B., Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus, Brain Res., 516 (1990) 248-256.
9. [9] Evans, M.C., Swan, J.H. and Meldrum, B.S., An adenosine analogue, 2-chloroadenosine, protects against long-term development of ischaemic cell loss in the rat, Neurosci. Lett., 83 (1987) 287-292.
10. [10] Forrester, T., Harper, A.M., MacKenzie, A.T. and Thomson, E.M., Effect of adenosine triphosphate and some derivatives on cerebral blood flow and metabolism, J. Physiol., 296 (1979) 343-355.
11. [11] Fredholm, B.B., Fastbom, J., Kvanta, A., Gerwins, B. and Parkinson, F., Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport, Fund. Clin. Pharmacol., 6 (1992) 99-111.
12. [12] Fredholm, B.B. and Lindström, K., The xanthine derivative 1-(5′-oxohexyl)-3-methyl-7-propylxanthine (HWA 285) enhances the actions of adenosine, Acta Pharmacol. Toxicol., 58 (1985) 187-192.
13. [13] Fredholm, B.B., Abbrachio, M.P., Burnstock, G., Daly, J.W., Harden, T.K., Jacobsen, K.A., Leff, P. and Williams, M., Nomenclature and classification of purinceptors, Pharmacol. Rev., 46 (1994) 143-156.
14. [14] Fredholm, B.B., Lindström, K. and Wallman-Johansson, A., Propentofylline and other adenosine transport inhibitors increase the efflux of adenosine following electrical or metabolic stimulation of rat hippocampal slices, J. Neurochem., 62 (1994) 563-573.
15. [15] Grome, J.J., Rudolphi, K. and Harper, A.M., Cerebrovascular effects of a xanthine derivative propentofylline (HWA 285), Drug Dev. Res., 5 (1985) 111-121.
16. [16] Grome, J.J. and Stefanovich, V., Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the cobscious rat, Naunyn-Schmiedebergs Arch. Pharmacol., 333 (1986) 172-177.
17. [17] Hagberg, H., Andine, P., Fredholm, B.B. and Rudolphi, K., Effect of adenosine uptake inhibitor propentofylline on extracellular adenosine and glutamate and evaluation of its efficacy after ischaemia in neonatal and adult rats. In J. Krieglstein and H. Oberpichler (Eds.), Pharmacology of Cerebral Ischaemia, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1990, pp. 427-437.
18. [18] Hagberg, H., Ostwald, C., Andersson, P., Lazerewicz, J. and Sandberg, M., Changes in extracellular purine catabolites and intracellular nucleotides, nucleosides and purines in the brain during ischaemia and reflow, J. Neurochem., 49 (1987) 227-231.
19. [19] König, J.F.R. and Klippel, R.A., The Rat Brain - A Stereotaxic Atlas, Williams and Wilkins, Baltimore, 1963.
20. [20] Kuschinsky, W., Coupling between function, metabolism and blood flow in the brain: state of the art, Microcirculation, 2 (1983) 357-378.
21. [21] McCulloch, J., Kelly, P.A.T. and Ford, I., Effect of apomorhine on the relationship between local cerebral glucose utilization and local cerebral blood flow (with an appendix on its statistical analysis), J. Cereb. Blood Flow Metab., 2 (1982) 487-489.
22. [22] Miller, R.G., Simultaneous Statistical Interference, MacGraw-Hill, New York, 1966.
23. [23] Newby, A.C., Adenosine and the concept of retaliatory metabolites, Trends Biochem. Sci., 9 (1984) 42-44.
24. [24] Park, C. and Rudolphi, K., Antiischemic effects of propentofylline (HWA 285) against focal cerebral infarction in rats, Neurosci. Lett., 178 (1994) 235-238.
25. [25] Parkinson, F.E., Paterson, A.R., Young, J.D. and Cass, C.E., Inhibitory effects of propentofylline on 3H adenosine influx, Biochem. Pharmacol., 46 (1993) 891-896.
26. 2 receptors and nitrobenzylthioinosine-sensitive nucleoside transporters: quantitative autoradiographic analysis, Eur. J. Pharmacol., 202 (1991) 361-366.
27. [27] Parkinson, F.E., Rudolphi, K.A. and Fredholm, B.B., Propentofylline: a nucleoside transporter inhibitor with neuroprotective effects in cerebral ischaemia. Gen. Pharmacol., 25 (1994) 1053-1058.
28. [28] Phillis, J.W. and Wu, P.H., The role of adenosine and its nucleotides in central synaptic transmission, Prog. Neurobiol., 16 (1981) 187-239.
29. [29] Raichle, M.E., Grubb, R.L., Gado, M.H., Eichling, J.O. and Ter-Pogossian, M.M., In vivo correlations between regional cerebral blood flow and oxygen utilization in man, Acta Neurol. Scand., 56 (1977) 240-241.
30. 1) receptors by caffeine treatment, Neurosci. Lett., 103 (1989) 275-280.
31. [31] Rudolphi, K.A., Keil, M. and Hinze, H., Effect of theophylline in ischaemically induced hippocampal damage in mongolian gerbils: a behavioral and histopathological study, J. Cereb. Blood Flow Metab., 7 (1987) 74-81.
32. [32] Rudolphi, K.A., Schubert, P., Parkinson, F.E. and Fredholm, B.B., Adenosine and Brain Ischaemia, Cerebrovasc. Brain Metab. Rev., 4 (1992) 346-369.
33. [33] Rudolphi, K.A., Schubert, P., Parkinson, F.E. and Fredholm, B.B., Neuroprotective role of adenosine in cerebral ischaemia, Trends Pharmacol. Sci., 13 (1992) 439-445.
34. 14C]antipyrine, Am. J. Physiol., 234 (1978) H59-H66.
35. 2+ influxes, Brain Res., 376 (1986) 382-386.
36. [36] Schubert, P. and Mitzdorf, U., Analysis and quantitative evaluation of the depressive effect of adenosine on evoked potentials in hippocampal slices, Brain Res., 172 (1979) 186-190.
37. [37] Siesjö, B.K., Brain Energy Metabolism, Wiley, New York, 1978.
38. [38] Sokoloff, L., Reivich, M., Kenedy, C., Des Rosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O. and Shinohara, M., The deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anaesthetised albino rat, J. Neurochem., 28 (1977) 897-916.
39. [39] Stefanovich, V., Uptake of adenosine by isolated bovine cortex microvessels, Drug Dev. Res., 8 (1983) 1459-1469.
40. [40] Von Lubitz, D.K.E.J., Dambrosia, J.M., Kempski, O. and Redmond, D.J., Protective effect of cylohexyladenosine in treatment of cerebral ischaemia in gerbils, Neuroscience, 30 (1989) 451-462.
41. [41] Winn, H.R., Rubio, G.R. and Berne, R.M., The role of adenosine in the regulation of cerebral blood flow, J. Cereb. Blood Flow Metab., 1 (1981) 239-244.