The effect of GABA and 5-HT receptor antagonists on rat dorsal root potentials

Neuroscience Letters

Volumn 217, Issue 2-3, 1996, Pages 153-156

  Thompson, S W N ^a   Wall, P D ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Dorsal root potential; GABA; Methysergide; Serotonin

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 8 [2 [(2,3 DIHYDRO 1,4 BENZODIOXIN 2 YL)METHYLAMINO]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE MESYLATE; ATROPINE; GRANISETRON; METHYSERGIDE; MORPHINE; N(G) NITROARGININE METHYL ESTER; NALOXONE; PHENTOLAMINE; PICROTOXIN; SEROTONIN 1A RECEPTOR; STRYCHNINE; SURAMIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; INTRAARTERIAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

EID: 0030592539     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)13097-4     Document Type: Article

References (29)

1. [1] Andrews, P.L., Davis, C.J., Bingham, S., Davidson, H.I. and Hawthorn, J., The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity, Can. J. Physiol. Pharmacol., 68 (1990) 325-345.
2. [2] Barron, D.H. and Matthews, B.H.C., The interpretation of potential changes in the spinal cord, J. Physiol., 92 (1938) 276-321.
3. B receptor pharmacology, Annu, Rev. Pharmacol. Toxicol., 33 (1993) 109-147.
4. [4] Cesselin, F., Laporte, A.-M., Miquel, M.-C., Bourgoin, S. and Hamon, M., Serotonergic mechanisms of pain control, Proc. 7th World Congress on Pain, (1994) 669-695.
5. [5] Eccles, J.C., Presynaptic inhibition in the spinal cord. In J.C. Eccles and K. Schad (Eds.), Physiology of Spinal neurones, Prog. Brain Res., 12, Elsevier, Amsterdam, (1964) 21-33.
6. [6] Eccles, J.C., Schmidt, R.F. and Willis, W.D., Pharmacological studies on presynaptic inhibition, J. Physiol. (London), 168 (1963) 500-530.
7. [7] Evans, R.H. and Long, S.K., Primary afferent depolarization in the rat spinal cord is mediated by pathways utilising NMDA and non-NMDA receptors, Neurosci. Lett., 100 (1989) 231-236.
8. [8] Gartside, S.E., Cowen, P.J. and Hjorth, S., Effects of MDL 73005EF on central pre-and postsynaptic 5-HT1A receptor function in the rat in vivo, Eur. J. Pharmacol., 191 (1990) 391-400.
9. [9] Gharagozloo, A., Holohean, A.M., Hackman, J.C. and Davidoff, R.A., Serotonin and GABA induced depolarization of frog primary afferent fibres, Brain Res., 532 (1990) 19-24.
10. [10] Hamon, M., Gallissot, M.C., Menard, F., Gozlan, H., Bourgoin, S. and Verge, D., 5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord, Eur. J. Pharmacol., 164 (1989) 315-322.
11. [11] Howland, B., Lettwin, J.Y., McCulloch, W.S., Puts, W. and Wall, P.D., Reflex inhibition by dorsal root interaction, J. Neurophysiol., 18 (1955) 1-17.
12. [12] Kidd, E.J., Laporte, A.M., Langlois, X., Fattaccini, C.M., Doyen, C., Lombard, M.C., Gozlan, H. and Hamon, M., 5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals, Brain Res., 612 (1993) 289-298.
13. [13] Kwiat, G.C. and Basbaum, A.I., The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat, Somatosens. Motor Res., 9 (1992) 157-173.
14. [14] Lamotte, C.C., Johns, D.R. and de Lanerolle, N.C., Immunohistochemical evidence of indolamine neurons in monkey spinal cord, J. Comp. Neurol., 206 (1982) 359-370.
15. [15] Levy, R.A., The role of GABA in primary afferent depolarisation, Prog. Neurobiol., 9 (1977) 211-267.
16. [16] Lloyd, D.P.C., Electrotonics in dorsal nerve roots, Cold Spring Harb. Symp. Quant. Biol., 17 (1952) 203-219.
17. [17] Moser, P.C., Tricklebank, M.D., Middlemiss, D.N., Mir, A.K., Hibert, M.F. and Fozard, J.R., Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam, Br. J. Pharmacol., 99 (1990) 343-349.
18. [18] Newton, B.W., Burkhart, A.B. and Harmll, R.W., Immunohistochemical distribution of serotonin in spinal autonomie nuclei: II. Early and late postnatal ontogeny in the rat, J. Comp. Neurol., 279 (1989) 82-103.
19. [19] Rees, H., Sluka, K.A., Westlund, K.N. and Willis, W.D., The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat, J. Physiol., 484 (1995) 437-445.
20. [20] Sillar, K.T. and Simmers, A.J., Presynaptic inhibition of primary afferent transmitter release by 5-HT, J. Neurosci., 14 (1994) 2636-2647.
21. [21] Sivilotti, L. and Nistri, A., GABA receptor mechanisms in the central nervous system, Prog. Neurobiol., 36 (1991) 35-92.
22. [22] Surahashi, Y., Young, W., Hassan, A.Z. and Park, R., Excitatory and inhibitory effects of serotonin on spinal axons, Neuroscience, 61 (1994) 645-653.
23. [23] Thompson, S.W.N., Gerber, G., Sivilotti, L.G. and Woolf, C.J., Long duration ventral root potentials in the neonatal rat spinal cord in vitro; the effects of ionotropic and metabotropic excitatory amino acid receptor antagonists, Brain Res., 595 (1992) 87-97.
24. [24] Thor, K.B., Nickolaus, S. and Helke, C.J., Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord, Neuroscience, 55 (1993) 235-252.
25. [25] Todd, A.J. and Spike, R.C., The localisation of classical transmitters and neuropeptides within neurones of the mammalian spinal cord, Prog. Neurobiol., 41 (1993) 609-646.
26. [26] Todorovic, S. and Anderson, E.G., 5-HT2 and 5-HT3 receptors mediate two distinct depolarizing responses in rat dorsal root ganglion neurons, Brain Res., 511 (1990) 71-79.
27. 1A receptors, Brain Res., 585 (1992) 212-218.
28. [28] Wall, P.D., Excitability changes in afferent fibre terminations and their relation to slow potentials, J. Physiol., 142 (1958) 1-21.
29. [29] Wall, P.D., Control of impulse conduction in long range branches of afferents by increases and decreases of primary afferent depolarization in the rat, Eur. J. Neurosci., 6 (1994) 1136-1142.