Novel computational methods for the determination of partition coefficients by planar chromatography

Journal of Chromatography A

Volumn 749, Issue 1-2, 1996, Pages 211-217

  Kleyle, Robert M ^a   Nurok, David ^a   Kossoy, Aaron D ^b   Burris, Stuart C ^b,c  

^a INDIANA UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Octanol water partition coefficients; Partition coefficients; Phenols

Indexed keywords

PHENOL DERIVATIVE;

ARTICLE; COMPUTER SIMULATION; EVALUATION AND FOLLOW UP; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; PARTITION COEFFICIENT; PRIORITY JOURNAL; TECHNIQUE;

EID: 0030592494     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9673(96)00420-7     Document Type: Article

References (17)

1. [1] J.C. Dearden and G.M. Bresnen, Quant. Struc.-Act. Relat., 7 (1988) 133.
2. [2] T. Fujita, J. Iwasa and C.J. Hansch, Am. Chem. Soc., 86 (1964) 5175.
3. [3] R.F. Rekker, The Hydrophobic Fragment Constant, Elsevier, New York, 1977.
4. [4] R. Kaliszan, Quantitative Structure-Chromatographic Retention Relationships; Chemical Analysis, Vol. 93, Wiley, New York, 1987, Ch 11.
5. [5] J.L. Biagi, M.C. Guerra, A.M. Barbaro, S. Barbieri, M. Recanatini, P.A. Borea and M.C. Pietrogrande, J. Chromatogr., 498 (1990) 179.
6. [6] E. Soczewinski and C.A. Wachtmeister, J. Chromatogr., 7 (1962) 311.
7. [7] P.J. Schoenmakers, H.A.H. Billiet, R. Tijssen and L. De Galan, J. Chromatogr., 149 (1978) 519.
8. [8) E. Soczewinski, Anal. Chem., 41 (1969) 179.
9. [9] E. Soczewinski, J. Chromatogr., 388 (1987) 91.
10. [10] S. Habibi-Goudarzi, K.J. Ruterbories, J.E. Steinbrunner and D. Nurok, J. Planar Chromatogr., 1 (1988) 161.
11. [11] A.D. Kossoy, D.S. Risley, R.M. Kleyle and D. Nurok, Anal. Chem., 64 (1992) 1345.
12. [12] M.S. Mirlees, S.J. Moulton, C.T. Murphy and P.J. Taylor, J. Med. Chem., 19 (1976) 615.
13. 18 Reversed Phase Plates, TLC Technical Series, Whatman Inc., Clifton, NJ, 1 (1981) 5.
14. [14] J.E. Garst and W.C. Wilson, J. Pharm. Sci., 73 (1984) 1616.
15. [15] C. Hansch and A. Leo, Pomona College Medicinal Data Base, MEDCHEM, ver. 3.53, Claremont, CA.
16. [16] A. Leo and C. Hansch, J. Org. Chem., 36 (1971) 1539.
17. [17] W. Klein, W. Kordel, M. Weiss and H.J. Poremski, Chemosphere, 17 (1988) 361.