A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families

Schizophrenia Research

Volumn 22, Issue 1, 1996, Pages 61-68

  Kunugi, Hiroshi ^a,d   Curtis, David ^a   Vallada, Homero P ^a   Nanko, Shin ^d   Powell, John F ^a   Murray, Robin M ^a   McGuffin, Peter ^b   Owen, Michael J ^b   Gill, Michael ^c   Collier, David A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c ST JAMES S HOSPITAL   (Ireland)

^d TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

chromosome 8; genetics; linkage; schizophrenia

Indexed keywords

DNA MARKER;

ADULT; ARTICLE; CHROMOSOME; FEMALE; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 0030592477     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-9964(96)00048-5     Document Type: Article

References (22)

1. Asherson, P., Mant, R. and McGuffin, P. (1995) Genetics and schizophrenia. In: S.R. Hirsch and D.R. Weinberger (Ed.), Schizophrenia. Blackwell, Oxford, pp. 253-274.
2. Coon, H., Jensen, S., Holik, J., Hoff, M., Myles-Worsley, M., Reimherr, F., Wender, P., Waldo, M., Freedman, R., Leppert, M. et al. (1994) Genomic scan for genes predisposing to schizophrenia. Am. J. Med. Genet. 54, 59-71.
3. Cottingham, R.W. Jr., Idury, R.M. and A.A. Schaffer (1993) Faster sequential genetic linkage computations. Am. J. Hum. Genet. 53, 252-263.
4. Curtis, D. and Gurling, H.M.D. (1993) A procedure for combining two-point lod scores into a summary multipoint map. Hum. Hered. 43, 173-185.
5. Curtis, D. and Sham, P.C. (1995) Model-free linkage analysis using likelihoods. Am. J. Hum. Genet. 57, 703-716.
6. Gill, M., McGuffin, P., Parfitt, E., Mant, R., Asherson, P., Collier, D., Vallada, H., Powell, J., Shaikh, S., Taylor, C., Sargeant, M., Clements, A., Nanko, S., Takazawa, N., Llewellyn, D., Williams, J., Whatley, S., Murray, R. and Owen, M. (1993) A linkage study of schizophrenics with DNA markers from the long arm of chromosome 11. Psychol. Med. 23, 27-44.
7. Gottesman, I.I. and Shields, J. (1982) Schizophrenia: The Epigenetic Puzzle. Cambridge University Press, Cambridge.
8. Gyapay, G., Morissette, J., Vignal, A., Dib, C., Fizames, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop, M. and Weissenbach, J. (1994) The 1993-94 Genethon human genetic linkage map. Nature Genet. 7, 246-339.
9. Kunugi, H., Nanko, S. and Kazamatsuri, H. (1995) A case of bipolar disorder with balanced chromosomal translocation. Biol. Psychiatry 38, 116-118.
10. Lathrop, G.M., Lalouel, J.M., Julier, C. et al. (1984) Strategies for multilocus linkage analysis in humans. Proc. Natl. Acad. Sci. USA 81, 3443-3446.
11. Lathrop, G.M., Lalouel, J.M., Julier, C. and Ott, J. (1985) Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am. J. Hum. Genet. 37, 482-498.
12. Lasseter, V.K., Pulver, A.E., Wolyniec, P., Kasch, L., Nestadt, G., Kazarian, H.H., Housman, D., Karayiorgou, M., Antonarakis, S.E., Meyers, D., Babb, R., Kimberland, M., Liang, K.Y., Ott, J., Blouin, J.L., Chen, H.M., Lalioti, M. and Morris, M. (1994) Schizophrenia: a genome search targets chromosomes 3 and 8 for exploration. Am. J. Hum. Genet. 55 (Suppl.), A192.
13. McGuffin, P., Katz, R. and Aldrich, J. (1986) Past and present state examination: the assessment of 'lifetime ever' psychopathology. Psychol. Med. 16, 461-465.
14. Moises, H.W., Kristbjarnarson, H., Yang, L., Wiese, C., Arolt, V., Schwinger, E., Macciardi, F., Blackwood, D., Coon, H., Byerley, W., Aschauer, H., Sjogren, B., Kennedy, J.L., Kidd, K.K., Wetterberg, L., Gottesman, I.I. and Helgason, T. (1995) A two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genet. 11, 321-324.
15. Risch, N. and Giuffra, L. (1992) Model misspecification and multipoint linkage analysis. Hum. Hered. 42, 77-92.
16. Sandkuijl, L.A. (1989) Analysis of affected sib-pairs using information from extended families. In: R.C. Elston, M.A. Spence, S.E. Hodge et al. (Eds.), Multipoint Mapping and Linkage Based upon Affected Pedigree Members, Genetic Analysis Workshop 6. Alan R. Liss, New York, NY, pp. 117-122.
17. Schaffer, A.A., Gupta, S.K., Shriram, K. and Cottingham, R.W. Jr. (1994) Avoiding recomputation in linkage analysis. Hum. Hered. 44, 225-237.
18. Smith, C.A.B. (1963) Testing for heterogeneity of recombination fraction values in human genetics. Ann. Hum. Genet. 27, 175-182.
19. Spitzer, R.L., Endicott, J. and Robins, E. (1978) Research Diagnostic Criteria for a Selected Group of Functional Disorders, 3rd edn. New York State Institute, New York, NY.
20. Weissenbach, J., Gyapay, G., Dib, C., Vignal, A., Morissette, J., Millasseau, P., Vaysseix, G. and Lathrop, M. (1992) A second-generation linkage map of the human genome. Nature 359, 794-801.
21. Wing, J.K., Cooper, J.E. and Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press, Cambridge.
22. Wood, S., Mitchell, H.K. and Schertzer, M. (1991) Isolation and analysis of dinucleotide repeat polymorphisms from a flow-sorted chromosome 8 library. Cytogenet. Cell Genet. 58, 1932.