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Volumn 6, Issue 24, 1996, Pages 2993-2998

Solid-phase synthesis of carbohydrate and phosphodiester modified 2'-5' oligoadenylate analogs

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DERIVATIVE; OLIGOADENYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0030591857     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00549-5     Document Type: Article
Times cited : (1)

References (30)
  • 17
    • 0015241313 scopus 로고
    • In our modification, the highly unstable diazomethane was replaced by trimithylsilyl diazomethane in the presence of tin chloride to give a mixture of 2′-and 3′-O-methyl isomers (40% and 60%, respectively)
    • 11. (a) Robins, M. J.; Naik, S. R. Biochim. Biophys. Acta 1971, 246, 341. In our modification, the highly unstable diazomethane was replaced by trimithylsilyl diazomethane in the presence of tin chloride to give a mixture of 2′-and 3′-O-methyl isomers (40% and 60%, respectively);
    • (1971) Biochim. Biophys. Acta , vol.246 , pp. 341
    • Robins, M.J.1    Naik, S.R.2
  • 18
    • 0011309534 scopus 로고    scopus 로고
    • note
    • 2O as mobile phase and C-18 silica as solid phase.
  • 22
    • 0001854265 scopus 로고
    • Eckstein, F., Ed.; IRL: Oxford
    • 15. Beaton, G.; Dellinger, D.; Marshall, W. S.; Caruthers, M. H. In Oligonucleotides and Analogs: A Practical Approach; Eckstein, F., Ed.; IRL: Oxford, 1991; pp 109-135. In our modification, tris(pyrrolidino)phosphine was prepared as described in Wiesler, W. T.; Marshall, W. S.; Caruthers, M. H. In Methods in Molecular Biology: Protocols for Nucleotides and Analogs; Agrawal, S., Ed.; Humana: Totawa, 1993; Vol 20, pp 191-206. In the second step of phosphorothioamidite preparation, three equivalents of tetrazole were used and reacted for the times noted in the text.
    • (1991) Oligonucleotides and Analogs: A Practical Approach , pp. 109-135
    • Beaton, G.1    Dellinger, D.2    Marshall, W.S.3    Caruthers, M.H.4
  • 23
    • 0027767925 scopus 로고
    • Agrawal, S., Ed.; Humana: Totawa, In the second step of phosphorothioamidite preparation, three equivalents of tetrazole were used and reacted for the times noted in the text
    • 15. Beaton, G.; Dellinger, D.; Marshall, W. S.; Caruthers, M. H. In Oligonucleotides and Analogs: A Practical Approach; Eckstein, F., Ed.; IRL: Oxford, 1991; pp 109-135. In our modification, tris(pyrrolidino)phosphine was prepared as described in Wiesler, W. T.; Marshall, W. S.; Caruthers, M. H. In Methods in Molecular Biology: Protocols for Nucleotides and Analogs; Agrawal, S., Ed.; Humana: Totawa, 1993; Vol 20, pp 191-206. In the second step of phosphorothioamidite preparation, three equivalents of tetrazole were used and reacted for the times noted in the text.
    • (1993) Methods in Molecular Biology: Protocols for Nucleotides and Analogs , vol.20 , pp. 191-206
    • Wiesler, W.T.1    Marshall, W.S.2    Caruthers, M.H.3
  • 28
    • 0011364406 scopus 로고    scopus 로고
    • note
    • 2O with phosphoric acid as external standard; phosphorodithioate, 113 ppm; phosphorothioate, 56 ppm.
  • 29
    • 0011365671 scopus 로고    scopus 로고
    • note
    • 4), actual mass 1330.29.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.