Peptide inhibitors of IκB protease: Modification of the C-termini of Z-LLF-CHO

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 24, 1996, Pages 2925-2930

  Suto, Mark J ^a   Sullivan, Robert W ^a   Ransone, Lynn J ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 8; PROTEINASE; TRIPEPTIDE;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOCHEMISTRY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUMINESCENCE; PEPTIDE SYNTHESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0030591853     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00559-8     Document Type: Article

References (16)

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7. 6. Personal Communication, Signal Pharmaceuticals, Inc.
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11. 10. Gassmann, P. G.; O'Reilly, N. J. J. Org. Chem. 1987, 52, 2481, Angelastro, M. R.; Burkhart, J. P.; Bey, P.; Peet, N. P. Tetrahedron Lett. 1991, 33, 3265.
12. 10. Gassmann, P. G.; O'Reilly, N. J. J. Org. Chem. 1987, 52, 2481, Angelastro, M. R.; Burkhart, J. P.; Bey, P.; Peet, N. P. Tetrahedron Lett. 1991, 33, 3265.
13. 11. Wasserman, H. H.; Ennis, D. S.; Power, P. L.; Rass, M. J.; Gomes, B. J. Org. Chem. 1993, 58, 4785.
14. 12. Palombella, V. J.; Golberg, A. L.; Maniatis, T. P.; Rando, O. PCT patent application, WO95/25533, Benzyloxycarbonyl-(2-naphthyl)alanine-(1-naphthyl)alanine-leucinal was prepared as described.
15. 13. Powers, J. C.; Harper, J. W. In Proteinase Inhibitors; Barrett and Salvesen, Eds.; Elsevier: New York, 1986; pp 55-156.
16. 2O/TFA. Compound 4a; mp 130-131 °C; FABMS m/e 569.4; Compound 4b; FABMS m/e 569.4; Compound 5a; mp 58-59 °C; FABMS m/e 510.3; Compound 5b; FABMS m/e 510.3; Compound 6; mp 135-137 °C; FABMS 628.3; Compound 8; FABMS m/e 546.3; Compound 11; mp 237-238 °C; FABMS m/e 669.2; Compound 14; FABMS m/e 672.4; Compound 18; FABMS m/e 496.2; Compound 19; FABMS m/e 643.5.