Functional groups positioned in unusual asymmetric microenvironments

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 24, 1996, Pages 3013-3016

  Rojas, Christian M ^a   Rebek Jr , Julius ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROCYCLIC COMPOUND; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; CATALYSIS; CHIRALITY; DRUG DESIGN; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

EID: 0030591834     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00548-3     Document Type: Article

References (14)

1. 1. For some recent examples and leading references, see: (a) Quan, R. W.; Li, Z.; Jacobsen, E. N. J. Am. Chem. Soc. 1996, 118, 8156.
2. (b) Trost, B. M. Acc. Chem. Res. 1996, 29, 356.
3. (c) Uematsu, N.; Fujii, A.; Hashiguchi, S.; Ikariya, T.; Noyori, R. J. Am. Chem. Soc. 1996, 118, 4916.
4. 2. Sharpless, K. B. Tetrahedron 1994, 50, 4235.
5. 3. For a review, see: Rebek, J., Jr. Angew. Chem., Int. Ed. Engl. 1990, 29, 245.
6. 4. Shimizu, K. D.; Dewey, T. M.; Rebek, J., Jr. J. Am. Chem. Soc. 1994, 116, 5145.
7. 5. Rebek, J., Jr.; Heagy, M. D, unpublished.
8. 6. Karayannidis, G.; Stamelos, D.; Bikiaris, D. Makromol. Chem. 1993, 194, 2789.
9. 4
10. 8. The amines were commercially available with the exception of the 1,2-dimethyl-β-hydroxyamine used in the synthesis of 4d which was prepared according to: Reetz, M. T.; Drewes, M. W.; Schmitz, A. Angew. Chem., Int. Ed. Engl. 1987, 26, 1141.
11. + 1404.4714, found 1404.4763.
12. + 1384.4663, found 1384.4679.
13. 11. (a) Armour, C. A.; Ryan, D. E. Can. J. Chem. 1957, 55, 1454.
14. (b) Priyadarshini, U.; Tandon, S. G. Anal. Chem. 1961, 33, 435.