Propentofylline inhibits polymorphonuclear leukocyte recruitment in vivo by a mechanism involving adenosine A(2A) receptors

European Journal of Pharmacology

Volumn 313, Issue 3, 1996, Pages 237-242

  Zhang, Yu ^a   Raud, Johan ^a   Hedqvist, Per ^a   Fredholm, Bertil B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenosine receptor; Myeloperoxidase; Polymorphonuclear leukocyte influx; Propentofylline; Xanthine

Indexed keywords

4 AMINO 8 CHLORO 1 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; MYELOPEROXIDASE; PROPENTOFYLLINE; THEOPHYLLINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PERITONITIS; PRIORITY JOURNAL;

EID: 0030591790     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00523-7     Document Type: Article

References (48)

1. Andiné, P., K.A. Rudolphi, B.B. Fredholm and H. Hagberg, 1990, Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischemia, Br. J. Pharmacol. 100, 814.
2. Banati, R.B., P. Schubert, G. Rothe, J. Gehrmann, K. Rudolphi, G. Valet and G.W. Kreutzberg, 1994, Modulation of intracellular formation of reactive oxygen intermediates in peritoneal macrophages and microglia/brain macrophages by propentofylline, J. Cereb. Blood Flow Metab. 14, 145.
3. Capecchi, P.L., L. Ceccatelli, U. Beermann, F. Laghi Pasini and T. DiPerri, 1993, Inhibition of neutrophil function in vitro by nimeluside. Preliminary evidence of an adenosine-mediated mechanism, Drug Res. 43, 992.
4. Cronstein, B.N., 1994, Adenosine, an endogenous anti-inflammatory agent, J. Appl. Physiol. 76, 5.
5. Cronstein, B.N., 1995, A novel approach to the development of anti-inflammatory agents: adenosine release at inflammatory sites. J. Invest. Med. 43, 50.
6. Cronstein, B.N., R.I. Levin, J. Belanoff, G. Weissmann and R. Hirschhorn, 1986, Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells, J. Clin. Invest. 78, 760.
7. 2 receptors, J. Immunol. 148, 2201.
8. Cronstein, B.N., D. Naime and E. Ostad, 1993, The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation, J. Clin. Invest. 92, 2675.
9. Damas, J. and P. Prunescu, 1993, Presence of immunoreactive platelet-activating factor in peritoneal exudate induced by zymosan in rats, Arch. Int. Pharmacodyn. Ther. 322, 115.
10. DeLeo, J., P. Schubert and G.W. Kreutzberg, 1988, Protection against ischemic brain damage using propentofylline in gerbils, Stroke 19, 1535.
11. 2, Prostaglandins 30, 769.
12. Dux, E., J. Fastbom, U. Ungerstedt, K. Rudolphi and B.B. Fredholm, 1990, Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus, Brain Res. 516, 248.
13. Engler, R., 1987, Consequences of activation and adenosine-mediated inhibition of granulocytes during myocardial ischemia, Fed. Proc. 46, 2407.
14. Fiedler, V.B. and J.V. Komarek, 1981, Effects of 1-(5′-oxohexyl)-3-methyl-7-propylxanthine (HWA 285) on viability of ischemic jeopardized myocardium after acute coronary artery occlusion and reperfusion, Arch. Int. Pharmacodyn. Ther. 254, 70.
15. Fredholm B.B. and E. Lindgren, 1984, The effect of alkylxanthines and other phosphodiesterase inhibitors on adenosine-receptor mediated decrease in lipolysis and cyclic AMP accumulation in rat fat cells, Acta Pharmacol. Toxicol. (Copenhagen), 54, 64.
16. Fredholm, B.B. and K. Lindström, 1986, The xanthine derivative 1-(5′-oxohexyl)-3-methyl-7-propylxanthine (HWA 285) enhances the actions of adenosine, Acta Pharmacol. Toxicol. 58, 187.
17. Fredholm, B.B., M.P. Abbracchio, G. Burnstock, J.W. Daly, T.K. Harden, K.A. Jacobson, P. Leff and M. Williams, 1994, Nomenclature and classification of purinoceptors, Pharmacol. Rev. 46, 143.
18. Fredholm, B.B., J. Fastbom, A. Kvanta, P. Gerwins and F. Parkinson, 1992, Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport, Fundam. Clin. Pharmacol. 6, 99.
19. 2 receptors mediate the inhibitory effect of adenosine on fMLP-stimulated respiratory burst in neutrophil leukocytes, Naunyn-Schmiedeberg's Arch. Pharmacol. 354 (in press).
20. Griffiths, R.J., S.W. Li, B. E. Wood and A. Blackham, 1991, A comparison of the anti-inflammatory activity of selective 5-lipoxygenase inhibitors with dexamethasone and colchicine in a model of zymosan induced inflammation in the rat knee joint and peritoneal cavity, Agents Actions 32, 312.
21. Grome, J.J. and V. Stefanovich, 1986, Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat, Naunyn-Schmiedeberg's Arch. Pharmacol. 333, 172.
22. Grome, J.J., K.A. Rudolphi and A.M. Harper, 1985, Cerebrovascular effects of a xanthine derivative propentofylline (HWA 285), Drug Dev. Res. 5, 111.
23. Gunther, G.R. and M.B. Herring, 1991, Inhibition of neutrophil superoxide production by adenosine released from vascular endothelial cells, Ann. Vasc. Surg. 5, 325.
24. Hawes, A.S., E. Fischer, M.A. Marano, K.J. Van Zee, C.S. Rock, S.F. Lowry, S.E. Calvano and L.L. Moldawer, 1993, Comparison of peripheral blood leukocyte kinetics after live Escherichia coli, endotoxin, or interleukin-1 alpha administration. Studies using a novel interleukin-1 receptor antagonist, Ann. Surg, 218, 79.
25. Hudlicka, O., J. Komarek and A.J. Wright, 1981, The effect of a xanthine derivative 1-(5′-oxohexyl)-3-methyl-7 propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits, Br. J. Pharmacol. 72, 723.
26. Kochanek, P.M. and J.M. Hallenbeck, 1992, Polymorphonuclear leukocytes and monocytes/macrophages in the pathogensis of cerebral ischemia and stroke, Stroke 23, 1367.
27. 4 and suppresses levels of resident and elicited leukocytes in acute inflammation, J. Immunol. 140, 228.
28. 1-selective adenosine agonist on rat acute models of inflammation and neutrophil function, Agents Actions 34, 25.
29. 51Cr-labeled cells and myeloperoxidase, Inflammation 7, 247.
30. Nathens, A.B., O.D. Rotstein, A.P. Dackiw and J.C. Marshall, 1995, Intestinal epithelial cells down-regulate macrophage tumor necrosis factor-alpha secretion: a mechanism for immune homeostasis in the gut-associated lymphoid tissue, Surgery 118, 343.
31. Nolte, D., H.A. Lehr and K. Messmer, 1991, Adenosine inhibits postischemic leukocyte-endothelium interaction in postcapillary venules of the hamster, Am. J. Physiol. 261, H651.
32. 2 receptor, Naunyn-Schmiedeberg's Arch. Pharmacol. 346, 234.
33. Parkinson, F.E., K.A. Rudolphi and B.B. Fredholm, 1994, Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia, Gen. Pharmacol. 25, 1053.
34. Perretti, M., E. Solito and L. Parente, 1992, Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice, Agents Actions 35, 71.
35. Rao, T.S., J.L. Currie, A.F. Shaffer and P.C. Isakson, 1994, In vivo characterization of zymosan-induced mouse peritoneal inflammation, J. Pharmacol. Exp. Ther. 269, 917.
36. Remick, D.G., R.M. Stricter, M.K. Eskandari, D.T. Nguyen, M.A. Genord, C.L. Raiford and S.L. Kunkel, 1990, Role of tumor necrosis factor-α in lipopolysaccharide-induced pathologic alterations, Am. J. Pathol. 136, 49.
37. Rudolphi, K.A., P. Schubert, F.E. Parkinson and B.B. Fredholm, 1992, Neuroprotective role of adenosine in cerebral ischemia, Trends Pharmacol. Sci. 13, 439.
38. Sarges R., H.R. Howard, R.G. Browne, L.A. Lebel, P.A. Seymour and B.K. Koe, 1990, 4-Amino[1,2,4]triazolo[4,3-α]quinoxalines. A novel class of potenl adenosine receptor antagonists and potential rapid-onset antidepressants, J. Med. Chem. 33, 2240.
39. Schrier, D.J., M.E. Lesch, C.D. Wright and R.B. Gilbertsen, 1990, The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats, J. Immunol. 145, 1874.
40. 2 antagonists, J. Med. Chem. 35, 2342.
41. Tarayre, J.P., A. Delhon, M. Aliaga, M. Barbara, F. Bruniquel, V. Caillol, L. Puech, N. Consul and J. Tisnë-Versailles, 1989, Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats, Pharmacol. Res. 21, 385.
42. Tordjman, C., F. Coge, N. Andre, H. Rique, M. Spedding and J. Bonnet, 1995, Characterisation of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro; interactions of non steroidal anti-inflammatory drugs with COX2, Biochim. Biophys. Acta 1256, 249.
43. Van de Langerijt, A.C., I. Huitinga, L.A. Joosten, C.D. Dijkstra, P.L. Van Lent and W.B. Van den Berg, 1994, Role of β2 integrins in the recruitment of phagocytic cells in joint inflammation in the rat, Clin. Immunol. Immunopathol. 73, 123.
44. Van der Poll, T., S.J. Van Deventer, C.E. Hack, G.J. Wolbink, L.A. Aarden, H.R. Büller and J.W. Ten Cate, 1992, Effects on leukocytes after injection of tumor necrosis factor into healthy humans, Blood 79, 693.
45. Weiss, S.J., 1989, Tissue destruction by neutrophils, New Engl. J. Med. 320, 365.
46. Winn, H.R., R. Rubio, R.R. Curnish and R.M. Berne, 1981, Changes in regional cerebral blood flow (rCBF) caused by increase in CSF concentrations of adenosine and 2-chloroadenosine (CHL-ADO), J. Cereb. Blood Flow Metab. 1, 401.
47. 2 receptors, adenosine inhibits the upregulation of Mac-1 (CD 11b/CD 18) expression on FMLP-stimulated neutrophils, Am. J. Respir. Cell. Mol. Biol. 9, 179.
48. Zhang, Y. and B.B. Fredholm, 1994, Propentofylline enhancement of the actions of adenosine on neutrophil leukocytes, Biochem. Pharmacol. 48, 2025.