Synthesis and antiviral activity of new phosphonobutoxypurines

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 18, 1996, Pages 2215-2218

  Harnden, Michael R ^a   Serafinowska, Halina T ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PURINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HERPES VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOCYTE; VARICELLA ZOSTER VIRUS;

HERPES; HERPESVIRIDAE; HUMAN HERPESVIRUS 3; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030591695     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00400-3     Document Type: Article

References (15)

1. 1. De Clercq, E.: Holy, A.; Rosenberg, I.; Sakuma, T.; Balzarini, J.; Maudgal, P. C. Nature 1986, 523, 464-467.
2. 2. Bronson, J. J.; Ghazzouli, I.; Hitchcock, M. J. M.; Webb, R. R.; Martin, J. C. J. Med. Chem. 1989, 32, 1457-1463.
3. 3. Duckworth, D. M.; Harnden, M. R.; Perkins, R. M.; Planterose, D. N. Antiviral Chem. Chemother. 1991, 2, 229-241.
4. 4. Balzarini, J.; Holy, A.; Jindrich, J.; Naesens, L.; Snoeck, R.; Schols, D.; De Clercq, E. Antimicrob. Agents Chemother. 1993, 36, 2726.
5. 5. Casara, P. J.; Altenburger, J. M.; Taylor, D.L.; Tyms, A. S.; Kenny, M.; Nave, J., F. Bioorg. & Med. Chem. Lett. 1995, 5, 1275-1280.
6. 6. Perkins, R. M.; Patience, C.; Ashton, R. J.; Love, S.; Barnes, K.; Jenkins, O.; Donker, G.; Reynolds, K.; Elphick, L. M.; Planterose, D. N.; Kenig, M. D.; Darlinson, S. J.; Vere Hodge, R. A.; Duckworth, D. M.; Serafinowska, H. T.; Harnden, M. R.; Weiss, R. A.; Brown, A. G. J. Cell. Biochem. 1992, Suppl. 16E, 86.
7. 7. Balzarini, J.; Naesens, L.; Slachmuylders, J.; Niphuis, H.; Rosenberg, I.; Holy, A.; Schellenkens, H.; De Clercq, E. AIDS 1991, 5, 21-28.
8. 8. Cundy, K. C.; Barditch-Crovo, P.; Walker, R. E.; Collier, A. C.; Ebeling, D.; Toole, J.; Jaffe, S. H. Antimicrob. Agents Chemother. 1995, 39, 2401-2405.
9. 9. Serafinowska, H. T.; Ashton, R. J.; Bailey, S.; Harnden, M. R.; Jackson, S. M.; Sutton, D. J. Med. Chem. 1995, 38, 1372-1379.
10. 10. Tsai, C. C.; Follis, K. E.; Sabo, A.; Beck, T. W.; Grant, R. F.; Bischofberger, N.; Benveniste, R. E.; Black, R. Science 1995, 270, 1197-1199.
11. 11. Cohen, J. Science 1995, 270, 1121-1122.
12. 12. Nystrom, J. E.; McCanna, T. D.; Helquist, R. A. Synthesis 1988, 56-58.
13. 13. Mitsunobu, O. Synthesis 1981, 1-28.
14. 14. Harnden, M. R.; Jarvest, R. L. J. Chem. Soc. Perkin Trans. 1, 1988, 2777-2784.
15. 2O: C, 27.87; H, 4.88; N, 18.05. Found: C, 28.00; H, 4.87; N, 17.85.