Cytogenetic damage measured in human sperm following cancer chemotherapy

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 355, Issue 1-2, 1996, Pages 235-252

  Robbins, Wendie A ^a  

^a USA   (United States)

Author keywords

anticancer drug; fluorescence in situ hybridisation; germ cell; Humster technique; sperm

Indexed keywords

ALLOPURINOL; ALTRETAMINE; AMINOPTERIN; ANTINEOPLASTIC AGENT; ASPARAGINASE; AZATHIOPRINE; BLEOMYCIN; BUSULFAN; CHLORAMBUCIL; CHLORMETHINE; CISPLATIN; COLCHICINE; CYCLOPHOSPHAMIDE; CYTARABINE; DACTINOMYCIN; DAUNORUBICIN; ETOPOSIDE; FLUOROURACIL; IFOSFAMIDE; LOMUSTINE; MERCAPTOPURINE; METHOTREXATE; MITOXANTRONE; PREDNISONE; TIOGUANINE; VINBLASTINE; VINCRISTINE;

CANCER CHEMOTHERAPY; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTOXICITY; HUMAN; PRIORITY JOURNAL; REVIEW; SPERM;

ANIMALIA;

EID: 0030591668     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00030-9     Document Type: Article

References (109)

1. Abruzzo, M.A. and T.J. Hassold (1995) Etiology of nondisjunction in humans, Environ. Mol. Mutagen., 25, suppl 26, 38-47.
2. Barone, J.G., J. DeLara, C.B. Cummings and W.S. Ward (1994) DNA organization in human spermatozoa, J. Androl., 15, 139-144.
3. Benet, J., J. Navarro, A. Genesca, J. Egozcue and C. Templado (1991) Chromosome abnormalities in human spermatozoa after albumin or TEST-Yolk capacitation, Human Reprod., 6, 369-375.
4. Berthelsen, J.G. (1987) Testicular cancer and fertility, Int. J. Androl., 10, 371-380.
5. Bishop. J.B. and J.S. Wassom (1986) Toxicological review of busulfan (Myleran), Mutation Res., 168, 15-45.
6. Bischoff, F.Z., D.D. Nguyen, K.J. Burt and L.G. Shaffer (1994) Estimates of aneuploidy using multicolor fluorescence in situ hybridization on human sperm, Cytogenet. Cell Genet., 66, 237-243.
7. Boring, C.C., T.S. Squires, T. Tong and S. Montgomery (1994) Cancer statistics 1994, CA Cancer, J. Clin., 44, 7-26.
8. Bramswig, J.H., U. Heimes, E. Heiermann, W. Schlegel, E. Nieschlag and G. Schellong (1990) The effects of different cumulative doses of chemotherapy on testicular function: Results in 75 patients treated for Hodgkin's disease during childhood or adolescence, Cancer, 6, 1298-1302.
9. Brandriff, B.F. and L.A. Gordon (1989) Analysis of the first cell cycle in the cross between hamster eggs and human sperm, Gamete Res., 3, 299-308.
10. Brandriff, B. and L. Gordon (1990) Human sperm cytogenetics and the one-cell zygote, in: J.W. Allen, B.A. Bridges, M.F. Lyon, M.J. Moses and L.B. Russell (Eds.), Biology of Mammalian Germ Cell Mutagenesis, Banbury, #34, Cold Spring Harbor Laboratory Press, pp. 183-194.
11. Brandriff, B.F. and L.A. Gordon (1992) Spatial distribution of sperm-derived chromatin in zygotes determined by fluorescence in situ hybridization, Mutation Res., 296, 33-42.
12. Brandriff, B., L. Gordon, L. Asworth, G. Watchmaker, D. Moore, A. Wyrobek and A. Carrano (1985) Chromosomes of human sperm: Variabiltiy among normal individuals. Hum. Genet., 70, 18-24.
13. Brandriff, B., L. Gordon, L.K. Asworth, G. Watchmaker and A.V. Carrano (1986a) Detection of chromosomal abnormalities in human sperm, Genetic Toxicology of Environmental Chemicals, Part B, in: Genetic Effects and Applied Mutagenesis, Alan R. Liss, pp. 469-476.
14. Brandriff, B., L. Gordon, L.K. Asworth, G. Watchmaker and A.V. Carrano (1986b) Detection of chromosomal abnormalities in human sperm, Prog. Clin. Biol. Res., 209B, 469-476.
15. Brandriff, B.F., L.A. Gordon, D. Moore and A.V. Carrano (1988) An analysis of structural aberrations in human sperm chromosomes, Cytogenet. Cell Genet., 47, 29-36.
16. Brandriff, B.F., L.A. Gordon and A.V. Carrano (1990) Cytogenetics of human sperm: structural aberrations and DNA replication. Prog. Clin. Biol. Res., 340B, 425-434.
17. Brandriff, B., L. Gordon and B. Trask (199la) A new system for high-resolution DNA sequence mapping interphase pronuclei. Genomics, 10, 75-82.
18. Brandriff, B.F., L.A. Gordon, R. Segraves and D. Pinkel (1991b) The male-derived genome after sperm-egg fusion: Spatial distribution of chromosomal DNA and paternal-maternal genomic association, Chromosoma, 100, 262-266.
19. Brandriff, B.F., L.A. Gordon and B.J. Trask (1991c) DNA sequence mapping by fluorescence in situ hybridization, Environ. Mol. Mutagen., 18, 259-262.
20. Brandriff, B.F., L.A. Gordon, K.T. Tynan, A.S. Olsen, H.W. Mohrenweiser, A. Fertitta, A.V. Carrano and B.J. Trask (1992) Order and genomic distances among members of the carcinoembryonic antigen (CEA) gene family determined by fluorescence in situ hybridization, Genomics, 12, 773-779.
21. Brandriff, B.F., M.L. Meistrich, L.A. Gordon, A.V. Carrano and J.C. Liang (1994) Chromosomal damage in sperm of patients surviving Hodgkins's disease following MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) therapy with and without radiotherapy, Hum. Genet., 93, 295-299.
22. Brouwers, P., R. Riccardi, P. Fedio and D.G. Poplack (1985) Long-term neuropsychologic sequelae of childhood leukemia: correlation with CT brain scan abnormalities, J. Pediatr., 106, 723-728.
23. Byrne, J. (1990) Fertility and pregnancy after malignancy. Semin. Perinatal., 14, 423-429.
24. Byrne, J., J.J. Mulvihill, M.H. Myers, R.R. Conelly, M.S. Naughton, M.R. Krauss, S.C. Steinhorn, D.D. Hassinger, D.F. Austin, K. Bragg, G.F. Holmes, F.F. Holmes, H.B. Latourette, P.J. Weyer, J.W. Meigs, M.J. Teta, J.W. Cook and L.C. Strong (1987) Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer, New Eng. J. Med., 317, 1315-1321.
25. Carl, W. (1986) Oral manifestations of systemic chemotherapy and their management, Semin. Surg. Oncol., 2, 187-199.
26. Collis, C.H. (1980) Lung damage from cytotoxic drugs, Cancer Chemother, Pharmacol., 4, 17-27.
27. Coonen, E., M. Pieters, J. Dumoulin, H. Meyer, J. Evers, F. Ramaekers and Geraedts (1991) Nonisotopic in situ hybridization as a method for nondisjunction studies in human spermatozoa, Mol. Reprod. Dev., 28, 18-22.
28. Damewood, M.D. and L.B. Grochow (1986) Prospects for fertility after chemotherapy or radiation for neoplastic disease, Fertil. Steril., 45, 443-459.
29. Draper, G.J. (1989) General overview of studies of multigeneration carcinogenesis in man, particularly in relation to exposure to chemicals, in: N.P. Napalkov, J.M. Rice, L. Tomatis, H. Yamasaki, (Eds.), Perinatal and Multigeneration Carcinogenesis, Lyon, International Agency for research on Cancer, pp. 275-314.
30. Eastmond, D.A. and D. Pinkel (1990) Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes, Mutation Res., 234, 303-318.
31. Eastmond, D.A., D.S. Rupa, H.W. Chen and L. Hasegawa (1993) Multicolor fluorescence in situ hybridization with centromeric DNA probes as a new approach to distinguish chromosome breakage from aneuploidy in interphase cells and micronuclei. in: B.K. Vig (ed) Chromosome Segregation and Aneuploidy. Berlin: Springer-Verlag, pp. 377-390.
32. Epstein C.J. (1986) The consequences of chromosomal imbalance: principles, mechanisms and models. Cambridge University Press, Cambridge, pp. 3-8, 253-343.
33. Estop A.M., K. Cieply, V. Vankirk, S. Munne and K. Garver (1991) Cytogenetic studies in human sperm, Hum. Genet., 87. 447-451.
34. Fromm, M., P. Littman, R.B. Raney, L. Nelson, S. Handler, G. Diamond and C. Stanley (1986) Late effects after treatment of twenty children with soft tissue sarcomas of the head and neck. Cancer, 57, 2070-2076.
35. Galloway, S.M. (1994) chromosome aberrations induced in vitro: Mechanisms, delayed expression, and intriguing questions, Environ. Mol. Mutagen., 23, Suppl. 24, 44-53.
36. Genesca, A., R. Miro, M.R. Caballin, J. Benet, J. Navarro, C. Templado, X. Bonfill and J. Egozcue (1987) Cancer Genet. Cytogenet., 29, 91-96.
37. Genesca, A., L. Barrios, R. Miro, M.R. Caballin, J. Benet, C. Fuster, X. Bonfill and J. Egozcue (1990a) Lymphocyte and sperm chromosome studies in cancer-treated men, Hum. Genet., 84, 353-355.
38. Genesca, A., J. Benet, M.R. Caballin, R. Miro, J.R. Germa and J. Egozcue (1990b) Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations, Hum. Genet., 85, 495-499.
39. Genesca, A., M.R. Caballin, R. Miro, J. Benet, J.R. Germa and J. Egozcue (1992) Repair of human sperm chromosome aberrations in the hamster egg, Hum. Genet., 89, 181-186.
40. Goldman, S. and F.L. Johnson (1993) Effects of chemotherapy and irradiation on the gonads, Adolesc. Endocrinol., 22, 617-629.
41. Green, D.M. (1989) Long-term Complications of Therapy for Cancer in Childhood and Adolescence, Johns Hopkins University Press. Baltimore MD, pp. 1-3, 109-134.
42. Green, D.M., M.A. Zevon, G. Lowrie, N. Seigelstein and B. Hall (1991) Congenital anomalies in children of patients who received chemotherapy for cancer in childhood and adolescence, N. Engl. J. Med., 325, 141-146.
43. Griffin, D.K., M.A. Abruzzo, E.A. Millie, L.A. Sheean, E. Feingold, S.L. Sherman and T.J. Hassold (1995) Non-disjunction studies of human sperm: evidence for a paternal age effect on trisomy, Hum. Mol. Genet., 4, 2227-2232.
44. Guttenbach, M. and M. Schmid (1990) Determination of Y chromosome aneuploidy in human sperm nuclei by non radioactive in situ hybridization. Am. J. Hum. Genet., 46, 553-558.
45. Guttenbach, M. and M. Schmid (1991) Non-isotopic detection of chromosome 1 in human meiosis and demonstration of disomic sperm nuclei, Hum. Genet., 87, 261-265.
46. Han, T.L., J. Ford, G.C. Webb, S.P. Flaherty, A. Correll and C.D. Matthews (1993) Simultaneous detection of X- and Y-bearing human sperm by double fluorescence in situ hybridization, Mol. Reprod. Dev., 34, 308-313.
47. Hansen, P.V. and S.W. Hansen (1993) Gonadal function in men with testicular germ cell cancer: The influence of cisplatinbased chemotherapy, Eur. Urol., 23, 153-156.
48. Hansen, P.V., K. Glavind, J. Panduro and M. Pedesen (1991) Paternity in patients with testicular cancer: Pretreatment and posttreatment findings, Eur. J. Cancer, 27, 1385-1389.
49. Hassold, T., F. Benham and M. Leppert (1988) Cytogenetic and molecular analysis of sex-chromosome monosomy, Am. J. Hum. Genet., 42, 534-541.
50. Hawkins, M.M. (1991) Is there evidence of a therapy-related increase in germ cell mutation among childhood cancer survivors? J. Natl. Cancer Inst., 83, 1643-1650.
51. Hecht, F. and B.K. Hecht (1987) Aneuploidy in humans: dimensions, demography and dangers of abnormal numbers of chromosomes, in: B.K. Vig and A.A. Sandberg (Eds.), Aneuploidy, Part A: Incidence and Etiology, Alan R. Liss, New York, pp. 9-49.
52. Holmes, J.M. and R.H. Martin (1993) Aneuploidy detection in human sperm nuclei using fluorescence in situ hybridization. Hum. Genet., 91, 20-24.
53. Hook, E.B. (1983) Perspectives in mutation epidemiology: 3. Contribution of chromosome abnormalities to human morbidity and mortality and some comments upon surveillance of chromosome mutation rates, Mutation Res., 114, 389-423.
54. Hook, E.B. (1985) The impact of aneuploidy upon public health: Mortality and morbidity associated with human chromosome abnormalities, in: V.L. Dellarco, P.E. Voytek and A. Hollaender (Eds.), Aneuploidy: Etiology and Mechanisms, Plenum Press. New York. pp. 7-33.
55. Horning, S.J., R.T. Hoppe and H.S. Kaplan (1981) Female reproductive potential after treatment for Hodgkin's disease. N. Eng. J. Med., 304, 1377-1382.
56. Hsu, L.Y.F. (1986) Prenatal diagnosis of chromosomal abnormalities in: A. Milunsky (Ed.), Genetic Disorders of the Fetus, New York, Plenum Press, pp. 115-183.
57. Jacobs, P.A. (1992) The chromosome complement of human gametes. Oxf. Rev. Reprod. Biol., 14, 47-72.
58. Jacobs, P.A., T.J. Hassold, E. Whittington, G. Butler, S. Collyer, M. Keston and M. Lee (1988) Klinefelter's syndrome: An analysis of the origin of the additional sex chromosome using molecular probes, Ann. Hum. Genet., 52, 93-109.
59. Jacobs, P.A., P.R. Betts, A.E. Cockwell, J.A. Crolla, M.J. Mackenzie, D.O. Robinson and S.A. Youings (1990) A cytogenetic and molecular reappraisal of a series of patients with Turner's syndrome, Ann. Hum. Genet., 54, 209-223.
60. Jenderny, J. and G. Rohrborn (1987) Chromosome analysis of human sperm. Hum. Genet., 76, 385-388.
61. Jenderny, J., M.L. Jacobi, A. Ruger and G. Rohrborn (1992) Chromosome aberrations in 450 sperm complements from eight controls and lack of increase after chemotherapy in two patients, Hum. Genet., 90, 151-154.
62. Joseph, A.M., J.R. Gosden and A.C. Chandley (1984) Estimation of aneuploidy levels in human spermatozoa using chromosome specific probes and in situ hybridization, Hum. Genet., 66, 234-238.
63. Kamiguchi, Y. and K. Mikamo (1986) An improved, efficient method for analyzing human sperm chromosomes using zona-free hamster ova, Am. J. Hum. Genet., 38, 724-740.
64. Kamiguchi Y., H. Tateno, Y. Iizawa and K. Mikamo (1995) Chromosome analysis of human spermatozoa exposed to anti-neoplastic agents in vitro, Mutation Res., 326, 185-192.
65. Magenis, R.E, (1988) Invited editorial: On the origin of chromosome anomaly, Am. J. Hum. Genet., 42, 529-533.
66. Martin, R.H. (1990) Human sperm chromosome complements: Effects of donor age, freezing and segregation in translocation and inversion carriers. Prog. Clin. Biol. Res., 340B. 435-445.
67. Martin, R. (1991) Chromosomal analysis of human spermatozoan, in: Y. Verlinsky and A. Kuliev (Eds.), Preimplantation Genetics, Plenum Press, New York, pp. 91-102.
68. Martin, R.H. and A. Rademaker (1987) The effect of age on the frequency of sperm chromosomal abnormalities in normal men, Am. J. Hum. Genet. 41, 484-492.
69. Martin, R.H. and A. Rademaker (1990) The frequency of aneuploidy among individual chromosomes in 6,821 human sperm chromosome complements, Cytogenet. Cell Genet., 53, 103-107.
70. Martin, R.H., C. Templado, E. Ko and A. Rademaker (1990) The effect of culture conditions and media on the frequency of chromosomal abnormalities in human sperm chromosome complements, Mol. Reprod. Dev., 26, 101-104.
71. Martin, R.H., E. Ko and A. Rademaker (1991) Distribution of aneuploidy in human gametes: Comparison between human sperm and oocytes, Am. J. Med. Genet., 39, 321-331.
72. Martin, R.H., K. Chan and E. Ko (1994) Detection of aneuploidy in human sperm by fluorescence in situ hybridization (FISH): different frequencies in fresh and stored sperm nuclei, Cytogenet. Cell Genet., 65, 95-96.
73. Martin, R.H., A.W. Rademaker and N.J. Leonard (1995) Analysis of chromosomal abnormalities in human sperm after chemotherapy by karyotyping and fluorescence in situ hybridization (FISH), Cancer Genet. Cytogenet., 80, 29-32.
74. McKeen, E.A., J.J. Mulvihill, F. Rosner and M.H. Zarrabi (1979) Pregnancy outcome in Hodgkin's disease, Lancet ii, 590-593.
75. Meadows, A.T. and W.L. Hobbie (1986) The medical consequences of cure, Cancer, 58, 524-528.
76. Mikamo, K., Y. Kamiguchi and H. Tateno (1990) Spontaneous and In Vitro radiation-induced chromosome aberrations in human spermatozoa: Application of a new method, in: M. Mendelsohn and R. Albertini (Eds.), Mutation and the Environment, Part B, Metabolism, Testing Methods and Chromosomes, Wiley-Liss, New York, pp. 447-456.
77. Mikamo, K., Y. Kamiguchi and H. Tateno (1991) The interspecific in vitro fertilization system to measure human sperm chromosomal damage, in: New Horizons in Biological Dosimetry, pp. 531-542.
78. Mulvihill, J.J., J. Byrne, S.A. Steinhorm, H.E. Fokke, M.H. Myers, R.R. Connelly, D.F. Austin, L.C. Strong, J.W. Meigs, H.B. Latourette, G.F. Holmes and F.F. Holmes (1986) Genetic disease in offspring of survivors of cancer in the young, Am. J. Hum. Genet., 39, A72.
79. Mulvihill, J.J., M.H. Myers and R.R. Connelly, D.F. Austin, J.W. Cook, F.F. Holmes, M.R. Krauss. J.W. Meigs, S.C. Steinhorn, M.J. Teta, M.H. Myers, J. Byrne, K. Bragg, D.D. Hassinger, G.F. Holmes, H.B. Latourette, M.D. Naughton, L.C. Strong and P.J. Weyer (1987) Cancer in offspring of long-term survivors of childhood and adolescent cancer, Lancet, ii, 813-817.
80. Munne, S. and A.M. Estop (1993) Chromosome analysis of human spermatozoa stored in vitro, Hum. Reprod., 8, 581-586.
81. Myers, S.E. and R.L. Schilsky (1992) Prospects for fertility after cancer chemotherapy, Semin. Oncol., 19, 597-604.
82. Nesbit, M.E. (1985) Late effects in successfully treated children with cancer, Clin. Oncol., 4, 195-355.
83. Olshan, A.F. (1995) Lessons learned from epidemiologic studies of environmental exposure and genetic disease, Environ. Mol. Mutagen., 25, Suppl 26, 74-80.
84. Pacchierotti, F. and Mailhes, J.B. (1991) Aneuploidy dose-responses following radiation or chemical exposures in mammals, in: New Horizons in Biological Dosimetry, Wiley-Liss, pp. 363-372.
85. Perreault, S.D. (1992) Chromatin remodeling in mammalian zygotes, Mutation Res. 296, 43-55.
86. Pieters, M.H.E.C., J.P.M. Geraedts, H. Meyer, J.C.M. Dumoulin, J.L.H. Evers, R.J.E. Jongbloed and P.M. Nederlof (1990) Human gametes and zygotes studied by nonradioactive in situ hybridization, Cytogenet. Cell Genet., 53, 15-19.
87. Robbins W.A., M.L. Meistrich, M.J. Cassel and A.J. Wyrobek (1994) Aneupioidy in sperm of Hodgkin's disease patients receiving NOVP chemotherapy, Am. J. Hum. Genet., 55, Suppl., A68.
88. Rosenbusch, B. and K. Sterzik (1991) Sperm chromosomes and habitual abortion, Fertil. Steril., 56, 370-372.
89. Rosenbusch, B., E. Strehler and K. Sterzik (1992) Cytogenetics of human spermatozoa: Correlations with sperm morphology and age of fertile men, Fertil. Steril., 58, 1071-1072.
90. Rudak, E., P.A. Jacobs and R. Yanagamachi (1978) Direct analysis of the chromosome constitution of human spermatozoa, Nature, 274, 911-912.
91. Schwartz, C.L., W.L. Hobbie and L.S. Constine (1994) Algorithms of late effects by disease, in: C.L. Schwartz, W.L. Hobbie, L.S. Constine, K.S. Ruccione (Eds.), Survivors of Childhood Cancer: Assessment and Management, Mosby-Year Book, St. Louis, pp. 7-19.
92. Seiber, S.M. and R.H. Adamson (1975) Toxicity of antineoplastic agents in man: Chromosomal aberrations, antifertility effects, congenital malformation, and carcinogenic potential, Adv. Cancer Res., 22, 57-155.
93. Senturia Y.D., C.S. Peckham and M.J. Peckham (1985) Children fathered by men treated for testicular cancer, Lancet, October 5, 766-769.
94. Severson, R.K. and L.L. Robison (1994) Methodologic and statistical issues in the study of late effects of childhood cancer, in: C.L. Schwartz, W.L. Hobbie, L.S. Constine, K.S. Ruccione (eds) Survivors of Childhood Cancer, Mosby-Year Book, St. Louis, MO, pp. 357-365.
95. Shelby, M.D. (1994) Human germ cell mutagens, Environ. Mol. Mutagen., 23 Suppl., 24, 30-34.
96. Sherins, R.J. and J.J. Mulvihill (1989) Gonadal Dysfunction in: V.T. de Vita Jr., S. Hellman, S.A. Rosenberg (Eds.), Cancer: Principles and Practice of Oncology, edition 3, Philadelphia, JB Lippincott, pp. 2170-2180.
97. Silverberg, E., C.C. Boring and T.S. Squires (1990) Cancer Statistics 1990, Ca-Cancer J. Clin., 40, 9-26.
98. Sokal, J.E. and E.M. Lessmann (1960) Effects of cancer chemotherapeutic agents on the human fetus, JAMA, 172, 1765-1771.
99. Spitz, S. (1948) The histologic effects of nitrogen mustards on human tumors and tissues, Cancer, 1, 383.
100. Tateno, H., Y. Kamiguchi and K. Mikamo (1992) A freezing and thawing method of hamster oocytes designed for both the penetration test and chromosome assay of human spermatozoa, Mol. Reprod. Dev., 33, 202-209.
101. Tomar D, E. Magenis, J. Chamberlin, L. Allen, S. Olson, T. Donlon, S. Barton, R. Sheeny and D. Waggoner (1984) Preferential paternal origin of de novo structural chromosome rearrangements, Am. J. Hum. Genet., 36, 115S.
102. Topley, J.M., J. Benson, M.V. Squier and J.M. Chessells (1979) Hepatotoxicity in the treatment of acute lymphoblastic leukaemia, Med. Pediatr. Oncol. 7, 393-399.
103. Viviani, S., A. Santoro, G. Ragni, V. Bonfante, O. Bestetti and G. Bonadonna (1985) Gonadal toxicity after combination chemotherapy for Hodgkin's disease: Comparative results of MOPP vs ABVD, Eur. J. Cancer Clin. Oncol., 21, 601-605.
104. Wallace, W.H.B., S.M. Shalet, M. Lendon and P.M. Morris-Jones (1991) Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia, Int. J. Androl., 14, 312-319.
105. Williams, B.J., C.A. Ballenger, H.E. Malter, F. Bishop, M. Tucker, T.A. Zwingman and T.J. Hassold (1993) Non-disjunction in human sperm: results of fluorescence in situ hybridization studies using two and three probes, Hum. Mol. Genet., 2, 1929-1936.
106. Wyrobek, A.J., T. Alhborn, R. Balhorn, L. Stanker and D. Pinkel (1990) Fluorescence in situ hybridization to Y chromosomes in decondensed human sperm nuclei, Mol. Reprod. Dev., 27, 200-208.
107. Yanagimachi, R. (1984) Zona-free hamster eggs: Their use in assessing fertilizing capacity and examining chromosomes of human spermatozoa, Gamete Res., 10, 187-232.
108. Young, R.C., M.A. Bookman and D.L. Longo (1990) Late complications of Hodgkin's disease management, Monogr. Natl. Cancer Inst., 10, 55-60.
109. Zalensky, A. Ol, J.W. Breneman, I.A. Zalenskaya, B.R. Brinkley and E.M. Bradbury (1993) Organization of centromeres in the decondensed nuclei of mature human sperm, Chromosoma, 102, 509-518.